NAD Therapy: How Effective Is NAD For Addiction Treatment?

Last Updated: July 6, 2020

Authored by Dr. Ahmed Zayed

Reviewed by Michael Espelin APRN

Addiction is a global concern that affects millions of people. Recent reports by the National Institute on Drug Abuse claims that there seems to be a concerning rise in drug usage among middle-aged adults, as well as some of the older adults in the United States. Different treatment methods have been suggested, but utilizing pharmaceutical drugs is often frowned upon. The NAD supplement is now a preferred method for the treatment of addiction. NAD therapy is a relatively new treatment option, but have been shown to hold the potential to assist in detoxification and recovery period. Read further to know how NAD therapy and NAD+ supplement could be used in addiction treatment programs.

NAD Therapy Definition

It has been found that the level of Nicotinamide Adenine Dinucleotide in the body of a person who abuses drugs, as well as those who drink too much alcohol, becomes depleted. The idea behind the use of NAD therapy is to use the NAD coenzyme in order to restore the chemical levels in the body of a person who had been using substances, such as illicit drugs, that led to a depletion of the compound in their system.

 preparing lady hand for NAD IV infusion

Different NAD Types

There are different ways in which NAD brain restoration therapy and addiction treatment may be administered to a patient.


While it is possible to take supplements that contain NAD Nicotinamide Adenine, it is important to note that the oral route often yields a reduced absorption rate. In turn, the bioavailability of the chemical in the body of the person will be much lower – which may not yield the benefits expected from this particular type of therapy.


NAD injections may sometimes be used, providing the patient with a high dose of the chemical. These injections will then be given at regular intervals to ensure levels of the compound in the individual’s body can be maintained at an adequate level to support them throughout the recovery period.

IV infusion

nurse adjusting NAD IV machine

Another option is to undergo NAD IV treatment. This is a type of treatment that may be utilized by rehabilitation centers that offer residential programs for the individual who is struggling to overcome their addiction. IV therapy may be done on a regular basis as well, which will help to maintain the levels of the NAD plus in the person’s body.

How NAD Therapy Helps

In these cases, the individual needs to understand what NAD+ does and consider the pros and cons of the therapy. In many cases, the use of NAD IV therapy or a different type of treatment would be recommended to a person when other methods have not yielded effective results. This may also be useful for those individuals who prefer not to replace the addiction that they are suffering from another type of pharmaceutical drug. Some of the medications used in the treatment of addiction may yield similar effects and could ultimately also cause the individual to undergo withdrawal symptoms when the use of the medicines are stopped.
For those who do not want to undergo treatment with pharmaceuticals, the use of NAD+ therapy provides a more natural alternative treatment approach.
It should be noted that this treatment is not used alone, as many people who become addicts suffer from an underlying psychological condition. This may include trauma, post-traumatic stress disorder, anxiety, or depression. The use of Nicotinamide Adenine Dinucleotide may assist with the addiction and withdrawal from the substances that were abused, but additional psychological therapies would also be needed to assure the successful recovery of the person.

Benefits Of NAD

Understanding the potential benefits provided to a person when undergoing addiction treatment with the use of NAD therapy is important. This can help the individual make a more informed decision when they are looking at the best way to overcome the substance abuse disorder that has developed.

Natural Relief

The primary benefit that is offered to a person when it comes to a NAD infusion treatment option is the fact that this is a more natural method of targeting addiction. The NAD vitamin does not have the same side-effects and potential risks involved compared to some of the pharmaceutical drugs that can be utilized in addiction treatment procedures.

Detox Help

It is also important to note that NAD therapy can be provided to some patients in an outpatient setting. There are some types of drug therapies where the patient will need to undergo residential detoxification and an inpatient treatment program.

female therapist regulating NAD IV infusion

Reduced Cravings

The use of this chemical may also help to effectively eliminate the drugs that may still be present in the person’s body when they are admitted to a treatment program. Furthermore, it has been found that this compound may be effective in reducing the cravings that the person experiences while they are withdrawing from the substances that were abused.

Energy Boost

Another important benefit is the fact that the NAD + supplement can help the body improve its efficacy in generating energy at a cellular level. This can help to ensure that the person does not experience a deficiency in energy or “crashes” while they are undergoing treatment.

Adverse Effects Of NAD Therapy

While many benefits can be expected, it is also important to understand the potential NAD+ side effects that may develop. Luckily, it has been found that the majority of people will not experience any significant side-effects as a direct cause of the chemical. There are cases where some people do experience some adverse effects, however. In these cases, the side-effects will usually be mild.
Side-effects may include:

  • stomach discomfort
  • diarrhea
  • nausea
  • headaches
  • indigestion
  • fatigue

Reasons To Use NAD Therapy For Addiction Treatment

There are two primary reasons why the NAD vitamin protocol is advised for the treatment of addiction.
First, the use of this particular compound can help to detoxify the person’s body. This means that the substances that were used will be flushed out of the system faster and more effectively. When this happens, the user is more likely to find that the withdrawal symptoms experienced during the detoxification period of their treatment pass faster.

doctor examining female patient before NAD detox
The second important reason why Nicotinamide Adenine Dinucleotide is often used to treat addiction is that the compound may reduce cravings for certain substances that the person might have abused in the past. This is a critical factor, as cravings may lead to relapse.
To achieve better results Nad Therapy can be accompanied with several other therapies like:

NAD Therapy Cost

NAD IV therapy cost depends on several factors, including the type of treatment program that is provided to the person with the addiction. Pricing will be higher for a residential treatment program, compared to an outpatient setting where the individual need to report to a center at specified dates. When additional protocols are needed, such as sessions with a counselor, such factors will also have an impact on the price that the person will need to pay for treatment.

Getting Help With NAD Therapy

Addiction is a serious disease, but there are several rehabs and centers available for people to overcome this type of disorder. Various NAD therapy locations are available throughout the United States. People should aim to find a NAD treatment center that is experienced in providing this type of therapy to people with existing addictions.
The use of drug and alcohol detox supplements may not always yield the most effective results, especially when used alone. After successful detox, a patient may feel like riding on a pink cloud. Although this temporary condition brings additional motivation to patient, it can ruin further necessary treatment activities. The person needs to ensure they are taken through the appropriate consultation process and provided with additional therapeutic services for a targeted and individualized approach.

Page Sources

  1. National Institute on Drug Abuse, Drug Use and Its Consequences Increase Among Middle-Aged and Older Adults,
  2. JOHN E. HUMISTON, Pharmacy Compounding Committee Review: Nicotinamide Adenine Dinucleotide (NAD+),

Published on: November 5th, 2019

Updated on: July 6th, 2020

About Author

Dr. Ahmed Zayed

Dr. Ahmed Zayed is a Bachelor of Medicine and Surgery. He is graduated from the University of Alexandria, Egypt. Dr. Ahmed Zayed has a passion for writing medical and health care articles and focuses on providing engaging and trustworthy information to readers.

Medically Reviewed by

Michael Espelin APRN

8 years of nursing experience in wide variety of behavioral and addition settings that include adult inpatient and outpatient mental health services with substance use disorders, and geriatric long-term care and hospice care.  He has a particular interest in psychopharmacology, nutritional psychiatry, and alternative treatment options involving particular vitamins, dietary supplements, and administering auricular acupuncture.


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