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Fiorinal: What Is Aspirin-Butalbital-Caffeine Capsule?

fiorinal drug

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Fiorinal is a prescription medication used to treat tension headaches. While the Fiorinal drug is widely used, many people who take it do not know as much as they should about the drug. Here is what users need to know to understand better what Fiorinal is.

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Table of Contents

Fiorinal Generic Names

The Fiorinal medication goes by numerous names. The generic name for Fiorinal is just a list of its ingredients. On most prescriptions, this appears as Butalbital/Aspirin/Caffeine.
Allergan Sales LLC is the only company that manufactures brand name medication in the United States. There is one generic for Fiorinal, which also has its own branding. Its name is Lanorinal.

It is common for people to believe that Fiorinal and Fioricet are the same medication. However, when comparing Fiorinal vs. Fioricet, it is important to note that while the barbiturate is the same in both, they have different pain-relieving agents, which means they are considered different medications.

Fiorinal Ingredients And Appearance

Fiorinal ingredients are broken down into active and inactive ones. For most patients, the active ingredients are the most important to know. The active ingredients in the Fiorinal medication are:

For those who have allergies, it may be important to know what is in medication beyond the active ingredients. While these ingredients are not meant to have an effect on the body, those with sensitivities and allergies could have negative reactions. The inactive ingredients in the Fiorinal drug are:

  • Cellulose, microcrystalline
  • Starch, corn
  • Talc
  • D&C yellow no. 10
  • FD&C green no. 3
  • Gelatin
  • Ferric oxide red

The brand name Butalbital/Aspirin/Caffeine medication is made in capsule form: one side is bright Kelly green, and the other is bright lime green. The capsules are 29mm in length and feature the imprint: FIORINAL 955.
fiorinal drug class

Fiorinal Drug Class

Users should know the Fiorinal drug class before taking the medication. Knowing this can help users understand how it acts on the body and what risks are associated with its use. Technically, butalbital/aspirin/caffeine is an analgesic combination, but there is more to look at than just that.

Why Is Fiorinal A Controlled Substance?

Fiorinal is a controlled substance. This means that the DEA has determined that it can be misused and abused by those taking it, and there is a risk of addiction. The medication has been classified as a Schedule III drug. This Fiorinal schedule means that the DEA considers the risks to be lower than with drugs that have a higher schedule and that there are clear therapeutic applications for the medication.

Is Fiorinal A Narcotic?

The term narcotic refers to drugs that are derived from opium in some manner, or, rarely, to opium itself. None of the ingredients in the Fiorinal is derived from opium. Thus, it would be incorrect to call it a narcotic.

Is Fiorinal An Opioid?

Opioids are drugs which mechanism of action involves acting on opioid receptors in the body. Fiorinal medication does not have any interaction with the opioid receptors. This means it cannot be classified as an opioid.

Is Fiorinal A Benzodiazepine?

Benzodiazepines are psychoactive drugs with a chemical structure composed of a benzene ring and a diazepine ring. While butalbital is a sedative, much like benzodiazepines are, it does not have this chemical structure. Thus, Fiorinal is not a benzodiazepine.
fiorinal use for migraine

Fiorinal Uses

As an analgesic combination, it can address pain. However, the butalbital/aspirin/caffeine combination is meant only to address two specific types of pain.

Fiorinal For Migraines

The first, and perhaps most common use is the application of Fiorinal for migraine management. Technically, this is an off label use. When prescribed for migraines, the user is meant only to take the medication when they feel a migraine starting. The migraine medication Fiorinal is not meant for frequent or daily use.

Fiorinal For Headaches

Fiorinal is a headache medicine as well: the medication is designed specifically to treat tension headaches; not all types of headaches are suited to treatment with the drug. If the tension headaches are frequent or constant, the medication may not be a good option as it is only meant for occasional use.

Contraindications And Warnings For Use

Butalbital/aspirin/caffeine should not be used in patients with the following:

  • Acute bronchospasm, angioedema, asthma, barbiturate hypersensitivity, carbamazepine hypersensitivity, hydantoin hypersensitivity, nasal polyps, NSAID hypersensitivity, salicylate hypersensitivity, tartrazine dye hypersensitivity, or urticaria.
  • Acute myocardial infarction, angina, cardiac arrhythmias, hypertension, hypotension, or cardiac disease.
  • Depression, mental status changes, or suicidal ideation.
  • Acid/base imbalance, chronic obstructive pulmonary disease (COPD), metabolic acidosis, metabolic alkalosis, pulmonary disease, respiratory acidosis, respiratory alkalosis, respiratory depression, sleep apnea, or status asthmaticus.
  • Diabetes mellitus, hypothyroidism, prostatic hypertrophy, renal disease, renal failure, renal impairment, systemic lupus erythematosus (SLE), thyroid disease, or urethral stricture.
  • Need for anticoagulant therapy or thrombolytic therapy.
  • Agranulocytosis, anemia, coagulopathy, hematological disease, hemophilia, hypoprothrombinemia, thrombocytopenia, thrombotic thrombocytopenic purpura (TTP), vitamin K deficiency, or von Willebrand’s disease.
  • Bone marrow suppression, immunosuppression, infection, or neutropenia.
  • Hepatic disease, hepatic encephalopathy, or hepatitis.
  • Alcoholism, bleeding, esophagitis, gastritis, GI bleeding, or peptic ulcer disease.
  • Ascites, dehydration, heart failure, hypovolemia, or sodium restriction.
  • CNS depression or use of other CNS depressants.
  • Influenza, Reye’s syndrome, varicella, or viral infection.
  • A habit of tobacco smoking.
  • G6PD deficiency.
  • Porphyria.
  • Gout.

The medication should not be used by people who need to drive or operate heavy machinery. It is also not meant for use in infants and children and should only be used in geriatric patients with extreme caution. Those with substance abuse problems are also contraindicated for butalbital/aspirin/caffeine use.

Fiorinal Dosage

Patients should always follow the Fiorinal dosage instructions provided to them by their doctor. While there is a standard dose, what is best for each individual patient will vary.
woman taking pills

Adult Dose

The standard adult dose is one to two Fiorinal capsules every four hours. Adults should not exceed six Fiorinal 50/325/40 capsules in a day. Anyone with renal or liver concerns should only use the medication with extreme caution under the supervision of a doctor.

Pediatric Dose

Children are generally considered to be contraindicated for use. However, some doctors may feel that their pediatric patient needs the medication. There are no standard doses of butalbital-aspirin-caffeine 50 mg-325 mg-40 mg capsules for children. Users must consult with their doctor to know what dose is safe.

Missed Dose

Patients who miss a dose should take it as soon as they realize they missed it unless it is very close to the time for their next dose. Double doses of the medication are dangerous and must be avoided.


The primary risk of butalbital/aspirin/caffeine comes from butalbital. The LD50 for butalbital is 160 mg per kilo. While lethal dose on it alone would require taking a significant amount of medication, other active ingredients, any concurrently used substances, and health conditions can make it possible to overdose on less.

Fiorinal Overdose

With any medication, including butalbital/aspirin/caffeine, users should be aware of the risk of overdose. Patients must understand that overdoses are not always from taking too much of a drug, but also from taking it with other substances, as well as taking it when contraindicated for use.

Can one Overdose On Fiorinal?

Overdosing on Fiorinal is possible. Technically, each of the three medications that make up the drug has overdose potential. The greatest potential is from butalbital. However, it is possible to overdose on aspirin and caffeine as well. While the risk with aspirin, and especially caffeine, is much lower than with butalbital, it is still there.

Signs And Symptoms Of Overdose

The signs and symptoms of a Fiorinal overdose are as follows: 

  • drowsiness
  • confusion
  • coma
  • respiratory depression
  • hypotension
  • hypovolemic shock
  • hyperpnea
  • vomiting and abdominal pain
  • tinnitus; hyperthermia
  • hypoprothrombinemia
  • restlessness
  • delirium
  • convulsions
  • insomnia
  • restlessness
  • tremor
  • delirium
  • tachycardia
  • extrasystoles
  • acid-base disturbances with the development of metabolic acidosis

fiorinal overdose treatment

Overdose Treatment

Anyone who reaches the Fiorinal overdose amount will require treatment to survive. This may include induced vomiting, gastric lavage, assisted breathing, diuresis, urine alkalinization, electrolyte balancing, and certain IV medications. In some cases, dialysis and blood transfusions may also be needed.

Fiorinal Side Effects

There are numerous side effects of Fiorinal. Many of these are uncommon or minor in effect. However, some are dangerous. The side effects below are classified by severity.

Mild Side Effects

  • Dizziness
  • Lethargy
  • Anxiety
  • Drowsiness
  • Vomiting
  • Flatulence
  • Nausea
  • Diarrhea
  • Insomnia
  • Tremor
  • Maculopapular rash
  • Purpura
  • Pruritus
  • Polyuria
  • Tinnitus

Moderate Side Effects

  • Tolerance
  • Depression
  • Excitability
  • Confusion
  • Constipation
  • Gastritis
  • Esophagitis
  • Palpitations
  • Sinus tachycardia
  • Respiratory depression
  • Jaundice
  • Hypertension
  • Hyperbilirubinemia
  • Hypoprothrombinemia
  • Hyperuricemia
  • Metabolic acidosis
  • Thrombocytopenia
  • Leukopenia

Severe Side Effects

  • GI bleeding
  • Anaphylactoid reactions
  • Anaphylactic shock
  • Hepatic necrosis
  • Hepatic encephalopathy
  • Toxic epidermal necrolysis
  • Erythema multiforme
  • Erythema nodosum
  • Proteinuria
  • Azotemia
  • Reye’s syndrome
  • Hearing loss
  • Disseminated intravascular coagulation
  • Aplastic anemia
  • Agranulocytosis
  • Hemolytic anemia
  • Pancytopenia
Additionally, users may be allergic to any of the active and inactive ingredients in Fiorinal. Symptoms of an allergy range from skin itchiness and rashes to anaphylactic shock. Anyone with a known allergy to the ingredients should avoid the medication.

Taking Fiorinal While Pregnant

Use of Fiorinal while pregnant is risky: all three active ingredients can be problematic for pregnant women as well as the fetuses they carry.
Potential effects of using the drug during pregnancy include:

  • constriction or premature closure of the fetal ductus arteriosus
  • increased perinatal mortality
  • intrauterine growth retardation
  • congenital salicylate intoxication
  • depressed albumin-binding capacity
  • abruptio placentae
  • hemorrhage
  • pulmonary hypertension
  • infant barbiturate dependence
  • seizures in the infant
  • hyperirritability in the infant

is fiorinal safe to take when pregnant
Fiorinal pregnancy category is C, meaning there are indications that it can cause problems, but there have not been enough studies to conclude the risks are both significant and greater than the potential benefits. As with pregnancy, Fiorinal while breastfeeding also poses certain health hazards. It is recommended that mothers stop taking the medication until breastfeeding is complete.

Fiorinal Drug Interactions

The Fiorinal interacts with numerous other drugs. There are 701 total known interactions. Some of these are:

  • Buprenorphine (major)
  • Codeine (major)
  • Ethanol (major)
  • Fentanyl (major)
  • Hydrocodone (major)
  • Ibuprofen (major)
  • Acetaminophen (moderate)
  • Cannabis (moderate)
  • Carisoprodol (moderate)
  • Cortisone (moderate)
  • Halazepam (moderate)
  • Insulin (moderate)
  • Chamomile (minor)
  • Desmopressin (minor)
  • Fenugreek (minor)
Users should discuss all medications and supplements they are taking with their doctor before they take butalbital/aspirin/caffeine.

Fiorinal High

While the drug has clinical applications, some of the effects of the medication can make it desirable to those looking to achieve a sense of euphoria. The Fiorinal high is caused by butalbital, a barbiturate and sedative.

Butalbital inhibits GABA neurotransmitters in the brain. This depresses the central nervous system and can cause feelings of extreme relaxation and wellbeing, while also eliminating things such as feelings of anxiety and depression.

If taken as directed by a doctor, users should not experience this high. However, those who take it in higher doses or through other means of ingestion, such as snorting Fiorinal, could experience it.

It is vital that users only take the medication as directed, as high doses or incorrect administration can be deadly.

Fiorinal Abuse

Fiorinal abuse occurs whenever someone takes the medication in a way other than as directed. This may mean:

  • taking the prescribed dose on a more frequent basis than directed;
  • taking higher doses than prescribed;
  • altering the medication in a way meant to make it easier to get high, which includes crushing it and potentiating it with other substances.

Abuse of Fiorinal is extremely dangerous and must be avoided.

Fiorinal Addiction

Fiorinal addiction is possible. Physically, the body can develop a tolerance to the drug, meaning that it will need more to achieve the same effects, putting the user at risk of overdose. Psychologically, the user can feel extreme dependence on the drug, believing it makes their life better or fearing that things like depression, anxiety, and pain will return if they stop abusing the drug. Anyone who feels compelled to take the drug or fears not using it should seek help for addiction.

Fiorinal Withdrawal

People who abuse the medication are at risk of experiencing Fiorinal withdrawal symptoms. If the medication is stopped suddenly, withdrawal symptoms should begin within 16 hours of the last dose. Major symptoms include convulsions and delirium, while others range from smaller tremors to fluish feelings. The worst symptoms should last five days or less, but others will last for about two weeks. For the safest experience, users need to withdraw from the drug under the supervision of doctors slowly.

Fiorinal Prices

The butalbital/aspirin/caffeine as a medication is only available with a prescription. It can be purchased from any reputable pharmacy, both in-store and online. The established retail prices of two reputable pharmacies are as follows:

Pharmacy name 30 capsules 60 capsules 90 capsules 120 capsules 180 capsules
CVS Pharmacy $49 $94 $141 $185 $277
Rite Aid $68 $111 $166 $222 $333

It is possible to save and have a cheap Fiorinal by using coupons from the manufacturer or others. Those with insurance coverage may be able to have the medication covered by their provider. However, because there are similar medications that are cheaper, the insurance company may request that another medication be prescribed if at all possible. If covered, the user may have to pay a percentage of the cost of the medication or just their copay.

When Fiorinal Use Becomes Dangerous

Even when use starts out innocently, the patients can become addicted to Fiorinal, making the drug dangerous. Anyone who is feeling cravings for the drug—physical or mental—needs to seek medical help, addiction treatment. No one is beyond help, and with the right drug rehab center, it is possible to get clean safely and live a better life.

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Find the best treatment options. Call our free and confidential helpline

Most private insurances accepted

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  1. Title 21 United States Code (USC) Controlled Substances Act. The US Department Of Justice.
  2. The United States 
Drug Enforcement Administration. Controlled Substances. 2019.
  3. The United States 
Drug Enforcement Administration. Narcotics (Opioids).
Isaak Stotts

About Author

Isaak Stotts, LP

Isaak Stotts is an in-house medical writer in AddictionResource. Isaak learned addiction psychology at Aspen University and got a Master's Degree in Arts in Psychology and Addiction Counseling. After graduation, he became a substance abuse counselor, providing individual, group, and family counseling for those who strive to achieve and maintain sobriety and recovery goals.


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