Celebrex Or Mobic: Which Drug Treats Pain And Inflammation Better?

Last Updated: July 17, 2020

Authored by Dr. Ahmed Zayed

Individuals experiencing pain and inflammation symptoms are provided with a range of opportunities in terms of pharmaceutical drugs that can be utilized to alleviate the symptoms. While Celebrex also known as celecoxib is a particularly popular option, Mobic may sometimes be prescribed as a Celebrex alternative. Patients should be acknowledged about the differences when it comes to comparing Celebrex vs. meloxicam.

Mobic or Celebrex: How These NSAIDs Work?

When looking at whether to use Celebrex or Mobic, it is essential to consider how these medications work and how fast they can relieve pain. They both belong to the same drug class. Celebrex and Mobic use primarily include the treatment of arthritis symptoms, including pain, stiffness, and inflammation.
Both of these drugs work by inhibiting the body’s ability to produce prostaglandins. These are molecules that signal pain. Prostaglandins play a part in the development of fever, as well as inflammation as well. Muscle pains are also signaled through the production of these molecules. Meloxicam and Celebrex both contain an enzyme that is known as cyclooxygenase. They are classified as COX-2 inhibitors. Thus, the production of prostaglandins is blocked with the use of these medications.

Celecoxib vs. Mobic Dosage Comparison

Yellow Celebrex capsule pills in spoonThe dosage of these drugs will usually depend on the severity of the patient’s symptoms. It is also essential to consider that these medications have different levels of dosages for various conditions.
When taking Mobic, the maximum advised daily dose of the medication is 15 mg. Most individuals will be given 7.5 mg per day, however. The physician will try to find the lowest dosage possible that still offers the person an effective alleviation of the symptoms they are suffering from. The medication is available in:

  • 5mg,
  • 7.5mg,
  • 10mg,
  • and 15mg doses.

Celebrex is available in various strengths, ranging from 50mg up to 400mg capsules. In adults with rheumatoid arthritis or osteoarthritis, the recommended daily dosage is 200mg. Many patients advice to take 100mg two times each day since the effects of the pill do not last for the entire day.

Celebrex vs. Meloxicam: Which Pills Act Faster?

Black man is experiencing stomachache after meloxicam ingestingWhen using Mobic 7.5 or any other dose, the medication usually acts within 1 hour and should be taken only once a day. Meloxicam is also able to provide relief of pain and inflammation for up to 24 hours.
celecoxib also starts acting within an hour, similar to meloxicam, but the effects of the medication do not last as long as Mobic. The reduction in pain and inflammation provided by Celebrex will wear off after the estimated eight hours. Most people will have to take the medication more than once per day.

Celebrex vs. Mobic: Which Drug Has Fewer Side Effects?

When a person is deciding whether to utilize meloxicam or Celebrex to assist in the treatment of pain symptoms, it is crucial for that individual to understand and compare the side-effects that have been associated with both of these drugs. This can assist in answering a question whether meloxicam is safe, for example.
Below is a comparison table of common side-effects of celecoxib vs. meloxicam:

Celebrex Meloxicam
Stomach upset
Runny or Stuffy Nose
Skin Rash
Sore Throat
Abdominal Pain

There are more severe adverse effects that a person may experience when using Celebrex or meloxicam. The severity of side-effects mostly depends on the dosage amount being taken. For example, meloxicam 7.5 side effects would not be as severe as for the higher dosage. Severe adverse effects of meloxicam vs. Celebrex are compared below:

Celebrex Meloxicam
Chest Pain
Shortness of Breath
Tarry or Bloody Stools
Coughing up Blood
Rapid Weight Gain

Mobic vs. Celebrex: Which One Will Be Safer and More Effective?

The safety of both drugs should be taken into account when looking at meloxicam vs. Celebrex. Many questions should be asked at this point, such as how long does it take for meloxicam to get out of the system? Other factors, such as Celebrex and meloxicam overdose amount also need to be accounted for. It is then crucial for the individual to ensure they closely follow the prescription provided to them to avoid taking too much of the drug, which may lead to an aggravation of side-effects or cause more serious adverse events to develop.

What are Mobic and Celebrex Risk Groups?

The specific reason why a person may require the medication also needs to be something that is taken into consideration. Generally, Celebrex is considered an effective option for the treatment of pain symptoms in people with rheumatoid arthritis, osteoarthritis, and juvenile rheumatoid arthritis. Individuals with menstrual cramps also sometimes use this drug to help relieve symptoms.
At the same time, individuals should be opting for an alternative to Celebrex if they have been diagnosed:

  • any heart-related conditions,
  • hives,
  • risk of asthma attack,
  • allergic reaction to aspirin

Even though the risk of cardiovascular complications is lower with Celebrex compared to some of the other NSAIDs that are available, the uncertainty still exists. Before using meloxicam medication patient’s medical history should also be checked with the physician. Meloxicam warnings and precautions should be checked as well.

What Dangerous Drug Interactions Are Known For Meloxicam and Celebrex?

Interactions between these two drugs and other medications that a person is taking also have to be taken into consideration. Meloxicam is known to have a serious interaction with sodium polystyrene sulfonate. Interactions may also occur with:

  • lisinopril,
  • apixaban,
  • Captopril,
  • Enalapril,
  • fosinopril,
  • apixaban,
  • ketorolac intranasal,
  • ketorolac,
  • moexipril,
  • quinapril,
  • tacrolimus.

medication box with many pills inlcuding meloxicamMobic interacts with tramadol and about 300 other drugs. A physician needs to consider the medical history of a patient before prescribing this drug. Celebrex is known to have interactions with:

  • alcohol,
  • Aliskiren,
  • abiraterone,
  • acetylsalicylic acid.

It also interacts with antacids that contain magnesium or aluminum, as well as amiodarone and aminoglycoside antibiotics. Again, the physician needs to ensure no interaction may occur with the person’s prescribed medications.

Mobic vs. Celebrex: What NSAID is the Best Rescue?

Arthritis is one of the common conditions treated with an NSAID like Celebrex, meloxicam or ibuprofen. It is, however, important to understand which one of the two drugs are more effective at treating these symptoms.
This can be a tricky question, unfortunately. Some individuals will respond better to Celebrex, while another person would rather be able to experience more significant relief of their symptoms with the help of meloxicam.
When celecoxib vs. meloxicam is compared, meloxicam tablet is known to have slightly fewer common side-effects associated with its use. Meloxicam is also the more affordable option and does not pose a significant risk in increasing a person’s likeliness of having a heart attack or other types of cardiovascular complications.

Page Sources

  1. Rui Luo, Gang Liu, Wei Liu, Fuxing Pei, Zongke Zhou, Jian Li, Bin Shen, Pengde Kang, Qibing Xie, and Xin Ma, Efficacy of celecoxib, meloxicam and paracetamol in elderly Kashin-Beck Disease (KBD) patients, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167448/
  2. Silverstein FE, Faich G, Goldstein JL, Simon LS, Pincus T, Whelton A, Makuch R, Eisen G, Agrawal NM, Stenson WF, Burr AM, Zhao WW, Kent JD, Lefkowith JB, Verburg KM, Geis GS, Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: A randomized controlled trial. Celecoxib Long-term Arthritis Safety Study, https://www.ncbi.nlm.nih.gov/pubmed/10979111
  3. Berna Demircan, Gülnaz Çelik, Halis Süleyman, Fatih Akçay, Effects of indomethacin, celecoxib and meloxicam on glutathione, malondialdehyde and myeloperoxidase in rat gastric tissue, https://www.tandfonline.com/doi/abs/10.1163/156856905774482797

Published on: May 14th, 2019

Updated on: July 17th, 2020

About Author

Dr. Ahmed Zayed

Dr. Ahmed Zayed is a Bachelor of Medicine and Surgery. He is graduated from the University of Alexandria, Egypt. Dr. Ahmed Zayed has a passion for writing medical and health care articles and focuses on providing engaging and trustworthy information to readers.


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  • Ellen Buck
    Mobec began giving me severe HA abd pain nausea vomiting tenitis vertigo..after a month.. I had to discontinue my use…e
    • Ellen Buck
      My physician…after mentioning my nausea.. Prescribed me xofran… not at all compatible.. In fact a dangerous combination. Now I feel extremely ill… have vomited while sleeping…Choking and gasping for air… I have a Rare Disease.. .LAM I am now fearful it may have injured my kidneys or abdomin, intestines Help… .