Meloxicam Drug Interactions: Can One Use Mobic With Tylenol Or Xanax?

Last Updated: July 17, 2020

Authored by Dr. Ahmed Zayed

Understanding meloxicam interactions with other drugs, foods and drinks are considered an essential factor for successful process. Numerous over-the-counter and prescription drugs are known to interact with this medication. Additionally, there are known interactions between meloxicam and certain types of foods, as well as some diseases. A thorough understanding of these drug interactions of meloxicam poses can help to make the use of the medication safer for the patient.

Meloxicam Drug Interactions

Meloxicam drug class is known as non-steroid anti-inflammatory drugs. It may interact with other medications, often causing a higher risk of internal bleeding, peptic ulcers, and other potential complications. Individuals asking whether meloxicam is similar to tramadol should understand that while both of these medications may have similar adverse drug interactions, they are categorized into two different classes.
In addition to considering the potential side-effects that a person may experience when using meloxicam, it is also crucial to understand the possible interactions that sometimes occur. The specific interactions may depend on Mobic dosage that the patient is using, as well as the dose of other medications that the individual is taking alongside the meloxicam. Both brand name and meloxicam generic drugs will have similar interactions since the same active ingredients are utilized.


Combining this medication with Amphotec, also known as Amphotericin B cholesteryl sulfate complex, may hold a risk of drug-induced renal toxicity. The individual’s renal function should be closely monitored during the administration of these drugs. Also, there is a higher risk of gastrointestinal bleeding when used alongside Arsenic Trioxide.


Meloxicam is also known to cause inhibition of platelet aggregation, so other platelet inhibitors like Abciximab (ReoPro) should not be ingested. The use of these two drugs together may cause these effects to be aggravated.


Since Mobic may have an impact on the blood pressure of a patient, using the medication with Acebutolol may cause an adverse effect. Individuals utilizing this combination should be monitored for blood pressure control, as well as for symptoms associated with renal insufficiency.


When used together with Acetohexamide, there may be an increase in the secretion of insulin in the person’s body. This may increase the risk of hypoglycemia. Thus, blood sugar levels should be closely monitored to detect such a condition and provide prompt treatment; thus avoiding possible complications.


Using Mobic together with Adefovir, particularly with chronic administration of the drugs, may lead to an interaction that causes the individual to suffer from nephrotoxicity. This can occur in people with normal renal function as well.

Combinations with Hydrochlorothiazide, Amlodipine or Aliskiren

The combination of Aliskiren, Hydrochlorothiazide, or Amlodipine with meloxicam may cause the antihypertensive effects of the drug to be reduced. In turn, the individual’s blood pressure control may be adversely affected.
The concurrent use of this medication and alpha-blockers may cause issues with blood pressure control and may also contribute to renal dysfunction.


Meloxicam and Prednisone together may cause an increase in the gastrointestinal side-effects associated with the use of NSAIDs when used over the long term.


The use of meloxicam and Lisinopril simultaneously may reduce the efficiency of Lisinopril in regulating the patient’s blood pressure levels.


The use of meloxicam and Acetaminophen together can cause serious adverse effects with the individual’s gastrointestinal system. This may include severe intestinal bleeding, which can become a life-threatening interaction in some cases. For this reason, meloxicam and Tylenol would also not be a recommended combination and may cause dangerous interactions.

Aldesleukin and Apixaban

The combination of Mobic and Aldesleukin poses a relatively high risk of causing the patient to suffer from nephrotoxicity. This may also contribute to a reduction in kidney function.
Combining meloxicam and Apixaban causes a significant increase in the risk of internal bleeding.


Meloxicam and Benadryl may also interact, due to the presence of Diphenhydramine. NSAID toxicity is the primary concern in this particular interaction.

Hydrocodone or Oxycodone

Meloxicam and Hydrocodone may lead to peptic ulcers, gastrointestinal perforation, and other serious complications. Similar complications may be observed when mixing Hydrocodone with different NSAIDs, such as when comparing meloxicam versus Celebrex.
Meloxicam and Oxycodone interaction includes a significant increase in the patient’s risk of experiencing complications with their gastrointestinal system.


Mobic and ibuprofen are also considered a serious drug interaction. This can significantly increase the risk of side-effects of both NSAIDs, including complications with the individual’s digestive system, so only one of them should be taken.

Meloxicam and Alcohol Interactions

Whiskey or in a shot glass and pack of meloxicam pillsMobic may cause interactions with certain food and drinks as well. Taking meloxicam with alcohol is one of the most important interactions to be concerned about. Meloxicam and its alternatives, prescription-only and OTC NSAIDs may cause similar interactions with alcohol as well. Alcohol use with the ZC 26 pill or any other form of meloxicam may cause a higher risk of internal bleeding and other side-effects, including peptic ulcer disease.

Meloxicam Disease Interactions

Whether a patient uses meloxicam for gout or any other condition, it is not only essential to consider drug-related interactions, but also take into account the fact that Mobic may interact with certain diseases as well. Certain conditions may become aggravated when the individual suffering from medical disease starts to use this drug. Some of the diseases that have been listed to have potential interactions with the medication include: Male medicine doctor checking meloxicam disease interactions

  • Myocardial infarction
  • Cardiac arrhythmias
  • Acute myocardial infarction
  • Thromboembolism
  • Cardiac disease
  • Heart failure
  • Peripheral vascular disease
  • Coronary artery disease
  • Cerebrovascular disease
  • Hypertension
  • Angina
  • Peptic ulcer disease

Individuals who have previously suffered a stroke are also advised to be cautious about using this drug. Furthermore, individuals who have existing diseases that affect their gastrointestinal tract and those who have previously experienced intestinal bleeding are also advised to be wary of the potential interactions that the medicine may have with their digestive system and stomach in particular.

Page Sources

  1. Angela K. Martinia, Cassandra M. Rodriguezb, Andrew P. Capb, Wenjun Z. Martinib, Michael A. Dubick, Acetaminophen and meloxicam inhibit platelet aggregation and coagulation in blood samples from humans,
  2. Meloxicam: MedlinePlus Drug Information,

Published on: May 14th, 2019

Updated on: July 17th, 2020

About Author

Dr. Ahmed Zayed

Dr. Ahmed Zayed is a Bachelor of Medicine and Surgery. He is graduated from the University of Alexandria, Egypt. Dr. Ahmed Zayed has a passion for writing medical and health care articles and focuses on providing engaging and trustworthy information to readers.


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  • Arlene solotoff
    I recently took levaquin for a lingering sinus infection. I started getting pain on my left shoulder and bicep causing weakness and pain. I stopped the levaquin and the orthopedic doctor prescribed Meloxicam 2x per day. 7.5 mg each time. I usually take benedryl tablet at night, Will this interfere with the Meloxicam ? Thanks for any input