As non-steroidal anti-inflammatory drug (NSAID) meloxicam is used for the treatment of pain and inflammation. Meloxicam is also sold under the brand names Mobic and Vivlodex. Inflammation in the joints tends to lead to symptoms that are generally associated with arthritis such as pain in the joints, tenderness, and swelling. The function of meloxicam as arthritis medication in these scenarios is to block the enzymes that produce prostaglandins, consequently reducing the levels of prostaglandins in the body and reducing the symptoms mentioned earlier. The drug has been approved for use and circulation since the year 2000.
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What is Meloxicam Used For?
In patients aged 2 years and over, meloxicam aims to treat the following health conditions:
- Swelling of the joints,
- Back pain,
- Tenderness of the joints,
- Pain in the joints,
- Stiffness, and other arthritis symptoms.
Can Meloxicam Be Used For Back Pain?
A study was carried out to see the length of time that it took for patients with back pain to see improvements. The results were as follows:
- Patients that used the Mobic 15 mg pills experienced a significant improvement in lower back pain after a week, according to 2015 study of oral meloxicam efficacy and tolerability. Ul 15 pills began to act within an hour of usage, improving the situation of the patient each day.
- Patients who received meloxicam injections into the lower back experienced reduced back pain after 24 hours. Three months later, they were active and experienced significantly less amount of pain.
- Patients who undergo the intravenous approach experienced immediate relief, as the drug began to act within 30 minutes of administration that is twice faster than oral intake.
Meloxicam Use For Arthritis
Mobic is recommended for the treatment of the symptoms of juvenile arthritis, rheumatoid arthritis, and osteoarthritis. The recommended dosage for these conditions varies according to the age and weight of the patient.
Meloxicam for Gout
Meloxicam is also effective for the treatment of gout. Mobic drug class is known for quick relief for people who suffer from acute gout episodes, and they can help to relieve the pain and shorten the attack if the drug is taken in the first twenty-four hours.
A study that involved treating gout patients with meloxicam proved that the drug helps to achieve an improvement if 15mg doses are administered orally once a day for 7 days.
Mobic Medication Usage
Meloxicam can be used in different forms – all in various types of dosages. There are tablets and capsules for patients that will use the pill form, and there are liquid forms that can be used orally, by injection or as a topical cream. To avoid Mobic OD, dosage form and its quantity must be previously discussed with a physician.
The patient is advised to use this drug with a lot of water (up to 240ml) unless the doctor says otherwise. For patients that go the route of using the liquid form orally, they are advised to shake the bottle gently and measure with a measuring device or spoon any time they want to take a dose from it. The dosages will be recommended as appropriate per patient by the doctor or pharmacist. This will also let the patient know how long they can take meloxicam for. Some other things that a patient should pay attention to when using meloxicam are:
- Do not lie down until at least ten minutes have passed since using the drug.
- If the patient notices stomach discomforts after using the drug, it can be taken with food or with an antacid.
- The lowest effective dose should be the recommended dose.
- Increasing the doses to be higher than is recommended increases the risks of stomach ulcers and bleeding.
- Do not switch between different forms of dosing (e.g., from the capsule to tablet) without the permission of a qualified doctor.
- Try to use the drug at the same time each day.
- Wait until at least two weeks before starting to worry about seeing results.
- Mixing Vivlodex and alcohol may result in severe gastrointestinal problems, so it is advised not to drink while one is on meloxicam.
Precautions and Warnings for Using Meloxicam
The possible side effects caused by not taking note of precautions appropriately is a major reason why meloxicam medical prescription is required. Most of those side effects can be avoided by paying more attention to detail.
If the patient knows that they are allergic to this NSAID, then they must inform the physician or pharmacist that prescribes it. Any other allergies should also be made known, just in case, they could cause any interference with the effectiveness or functionality of the drug. Other NSAIDs like Celebrex could also be prescribed in such cases.
Providing an Up-To-Date Medical History
The doctor or pharmacist also needs to be aware of the medical history of the patient. If a patient has any of the following conditions in their medical history, the prescription may need to be reconsidered:
- stomach or intestine problems (e.g., ulcers, bleeding, recurring heartburns)
- high blood pressure
- heart/liver disease
- growths in the nose
- bleeding/clotting problems or blood disorders.
It should be noted that using NSAID drugs such as meloxicam sometimes leads to kidney problems. These problems could occur primarily if the medication is used while the patient is dehydrated, has kidney disease, has heart failure, takes certain drugs that interfere with NSAIDs or is an older adult. Dehydration should be avoided by drinking fresh water regularly, and any kidney problems can be quickly identified if the patient notices a change in the amount of urine that they pass.
Taking Before, During or After Pregnancy Period
Women who are going to bear children are advised to speak extensively with the physician about all the possible effects – both positive and negative – that using meloxicam may have on childbearing. For one, it is generally forbidden to use the drug in the first or last trimester of pregnancy, as it may affect the unborn child or lead to complications during labor or delivery. It is recommended to pregnant women to taper off meloxicam unless the physician confirms that it is needed.
Meloxicam Mechanism of Action
Meloxicam blocks the enzyme that converts arachidonic acid into prostaglandins – mediators of inflammation. By inhibiting the production of these prostaglandins, the risks of inflammation are significantly reduced, and the symptoms of the patient begin to disappear. Meloxicam’s mechanism of action can occur in five stages:
- Anti-inflammatory activity: this happens with the decreased synthesis of prostaglandins through the inhibition of the COX-1 and COX-2 isoenzymes, reducing inflammation.
- Analgesic activity: this occurs when inflammation has occurred and has affected the sensitivity of pain receptors. NSAIDs such as meloxicam have an analgesic effect by stopping the production of more prostaglandins that cause inflammation.
- Antipyretic activity: at this stage, the drug’s suppression of prostaglandins synthesis helps the body to return to normal temperature.
- GI Effects: this refers to any gastrointestinal side effects that may occur as a result of using the drug. The inhibition of COX-1 is primarily known to be responsible for it.
- Renal Effects: the prostaglandins suppressed by meloxicam are key regulators of water and sodium needed for proper renal function. Therefore, administration of meloxicam may lead to a decrease in blood flow which could lead to renal failure or increased blood pressure in some individuals.
To avoid severe Mobic side effects, it is imperative to completely understand and follow appropriate prescriptions before using drugs such as meloxicam.