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Buspar Interactions – Is It Safe To Combine With Other Drugs?

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As an anti-anxiety drug, it is common to find Buspirone combined with other drugs to treat anxiety disorders. Buspar pill combined with other drugs and substances can lead to major Buspirone drug interactions. As with any drug, certain Buspirone interactions can be either mild or fatal. Buspar interactions may lead to side effects such as dizziness, drowsiness. One must always disclose existing health conditions before taking Vanspar, as certain Buspar combinations can be harmful.

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Learn About The Drug Interactions With Buspirone:

Buspirone And Alcohol Combination

The combination with alcohol is not fatal, however, it does exacerbate the effects of alcohol. Consuming Buspirone with alcohol can increase its sedative effect, causing dizziness and lightheadedness. It is generally best to avoid consuming this medicine and alcohol together.
So, how long does Buspar last? Generally, effects stay for a couple of hours, especially when it is paired with alcohol.

The absence of major interactions does not mean the safety of combined use.

Vanspar And Weed Interaction

Technically, a combination with marijuana is also not fatal. However, taking Buspar and weed together can still have undesirable effects such as impaired judgment, difficulty concentrating, and drowsiness. As most users know, marijuana shows up on urinary drug tests. So, does Buspar show up on a drug test? It is, in fact, one of the drugs that can lead to false-positive results on a urinary drug test.
Man Smoking Weed Joint

Buspar And Wellbutrin Combination

Taking Buspar and Wellbutrin together is generally safe, and there are no known interactions with Wellbutrin. Some doctors may even prescribe a Buspirone Wellbutrin combination. Of course, one should always follow the correct directions from a doctor for such a combination.
A poorly calculated dose combination can cause paranoia and hallucinations. It is also important to note that neither drug should be used in combination with MAO inhibitors.

Buspirone And Xanax Interaction

Increasing demand has caused a Buspar shortage, but there are plenty of alternative drugs used to treat anxiety. Some people mistake Xanax and Buspar to be the same thing, but they are a different class of drugs. There is, however, no indication that a Buspar Xanax interaction is dangerous. Nonetheless, there may be a mild sedative effect as a result of the interaction.

Buspirone And Zoloft Interaction

Zoloft falls under a drug class known as SSRIs (Selective Serotonin Reuptake Inhibitors) antidepressant. The combination leads to one of the more serious interactions. Taken together, the combination can lead to serotonin syndrome, a condition that is manifested with symptoms like hallucinations, major changes in blood pressure, seizures, and muscle spasms. This is one of the interactions that could even result in a coma or death.

Always consult with the doctor before taking a combination of drugs. By doing so, one can prevent the presence of adverse reactions and minimize risks to health.

Buspirone And Lexapro Interaction

Buspirone hydrochloride is an anti-anxiety drug that works by influencing serotonin levels in the brain. Lexapro is another SSRI drug, which means a Lexapro and Buspar interaction elevates the risk of serotonin syndrome. It is important to remember that it happens on a rare occasion and requires immediate medical attention.
Old Man Takes His Pills

Vanspar And Adderall Combination

Adderall is used to treat ADHD. Buspar and Adderall can be taken together as Buspirone also seems to improve ADHD symptoms. However, this can elevate the risk of serotonin syndrome as they both affect serotonin levels. Serotonin syndrome can lead to coma or death if left unattended.

Vanspar And Grapefruit Juice Interaction

Apart from drug interactions, one must also be wary of certain foods. A Buspar grapefruit interaction raises the drug’s concentration in the body, which can intensify its side effects. Though rare, typical side effects of Buspar include dizziness, drowsiness, and blurred vision.
To avoid grapefruit and Buspar interaction, one must limit the consumption of grapefruit or grapefruit juice while taking Buspar.

Even regular foods can cause interactions with subsequent unpleasant effects. Consult with the doctor on dietary habits upon the prescription of the medication.

Avoiding Dangerous Interactions

With Buspar, it is imperative to disclose all medications and health issues to a doctor. While Buspirone itself is slow acting and relatively safe, its concentration can be increased significantly with certain Buspar drug interactions.
The problem with most of these Buspirone drug interactions is that if the correct dosages aren’t taken, it can lead to fatal overdoses. So, can one overdose on Buspirone? Yes, it is possible to overdose on medicine alone. Abuse of Buspirone requires thorough substance abuse and addiction treatment. One can receive such services in a specialized rehabilitation facility for substance abusers. The role of the treatment course is to withdraw, detoxify, and recover from the addiction. This will help the victim of dependence to return to a previously healthy and meaningful life.

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  1. Kiani, J., & Imam, S. Z. (2007). Medicinal importance of grapefruit juice and its interaction with various drugs. Nutrition journal, 6, 33.
  2. Budur, K., Mathews, M., Adetunji, B., Mathews, M., & Mahmud, J. (2005). Non-stimulant treatment for attention deficit hyperactivity disorder. Psychiatry (Edgmont (Pa. : Township)), 2(7), 44–48.
Isaak Stotts

About Author

Isaak Stotts, LP

Isaak Stotts is an in-house medical writer in AddictionResource. Isaak learned addiction psychology at Aspen University and got a Master's Degree in Arts in Psychology and Addiction Counseling. After graduation, he became a substance abuse counselor, providing individual, group, and family counseling for those who strive to achieve and maintain sobriety and recovery goals.


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