Baclofen Interactions: Can Baclofen and Tramadol Be Taken Together?

Last Updated: June 3, 2020

Authored by Sharon Levy, MD, MPH

Baclofen, also known under brand names Lioresal and Gablofen is widely used as a muscle relaxant for individuals struggling with spinal cord-related injuries and muscle spasms. Baclofen interactions are basically the reactions or effects that might take place after taking Gablofen with other drugs or while on different medications. Some of these reactions may be mild, but some of them can bring severe harm to patients health.

There is a list of some medications and substances that have been tested in combination with Baclofen doses and appeared as dangerous:

  • Alcohol
  • Antihistamines
  • Antipsychotics
  • Aripiprazole
  • Azelastine
  • Buprenorphine
  • Codeine
  • Gabapentin
  • Insulin
  • Mirtazapine
  • Monoamine oxidase inhibitors
  • Morphine
  • Olopatadine
  • Phenytoin
  • Pramipexole
  • Ropinirole
  • Tramadol, and many more.

Lioresal interacts with these medications and substances differently. Baclofen interactions may be severe (major) or moderate (mild) depending on the drug combination.

Major Baclofen Interactions

Pharmacology expert comparing pillsThis term means that the interaction between the Gablofen and another drug may cause major health issues for the client ingesting it. This kind of interactions is dangerous as side effects ranging from extreme drowsiness to death may occur. A major interactions patients should avoid are:

Baclofen vs. Tramadol

Utilizing Tramadol and Baclofen together may lead to severe side effects such as going into a coma, respiratory difficulties, and even death. It is also known that using cough medications in combination with other medications or substances can lead to a depression of the CNS.

Lioresal With Opioids

Using opioid painkillers in combination with Lioresal is prohibited. Baclofen and Vicodin or Baclofen and Norco interactions are very dangerous. Combining such substances may result in severe side effects of both drugs or even cause coma or death.

Moderate Lioresal Interactions

This kind of interactions may cause mild health concerns such as Baclofen common side effects like dizziness and impaired thinking. Patients are advised to visit their doctors before combining drugs and substances mentioned below.

Baclofen vs. Xanax

Baclofen pills in two bucketsUsing Baclofen and Xanax together might not result in death or coma, but it may increase the chances of experiencing ill health symptoms.  Symptoms may include dizziness, concentration difficulties, drowsiness, and more. Operating heavy or dangerous machinery should be avoided when taking these medications.

Can one take Tylenol with Baclofen?

Clients must consult their doctors before taking Tylenol as using both together may cause a moderate interaction. Confusion, dizziness, inability to concentrate, drowsiness, and more can occur when both substances are taken together.

Can one take Ibuprofen with Baclofen?

Using Baclofen and Ibuprofen 800 can cause a moderate interaction between both prescriptions. Taking Ibuprofen and Baclofen may result in side effects in elderly ranging from impairment in judgment and thinking to problems with coordination and motor skills. Usual moderate interactions result in drowsiness and dizziness.

Taking Gabapentin and Baclofen together

Using Neurontin aka Gabapentin and Baclofen together may lead to moderate side effects such as confusion and dizziness. Gabapentin is a medicine used to treat seizures and panic disorders and as such, using Baclofen and Clonazepam will offer the same side effects. Clonazepam is also used to treat seizures and panic disorders. Activities requiring body and mind concentration such as driving and heavy machinery must be avoided when taking both medications together.

Other moderate interactions include taking Lyrica and Baclofen, Naproxen and many more.

When compared to analogs, for example, Cyclobenzaprine vs. Baclofen offers similar results as cyclobenzaprine must be used within a short term period, because of its addictive tendencies.

Can Gablofen Be Taken With Alcohol?

It is very dangerous to mix any drug with alcohol as it can be harmful. The same principle goes for Baclofen and alcohol as combining both will double the depressant effects. If a dose of Lioresal in a client’s system and alcohol will mix, it will heighten the adverse effects. Mixing both will cause side effects such as: Patient is taking Baclofen with a glass of alcohol

  • Drowsiness
  • Impaired thinking
  • Dizziness
  • Confusion, and many more.

It is known that Gablofen medication works as a muscle relaxant and for reducing alcohol cravings in patients. Although Lioresal provides a strong anxiolytic effect, there are other drugs which are made explicitly for treating such issues.

Take Gablofen With Cautiousness

Patients must consult their doctors before taking any other medication with Lioresal. It can’t be stopped at any time as it may lead to severe withdrawal symptoms. Stopping Baclofen is a gradual process and clients must talk to their physicians before beginning the process.

Using Lioresal for recreational purposes is prohibited. Nevertheless, it is hardly possible to get high on Baclofen because of its mechanism of action.

Taking an excessive amount of pills can lead to Baclofen OD. This condition is risky and can result in severe adverse effects which include high blood pressure, hypothermia, and even coma.

Page Sources

  1. Suzette M. Evans, Adam Bisaga, Acute Interaction of Baclofen in Combination with Alcohol in Heavy Social Drinkers,
  2. Andrew Meillier, Cara Heller, Shyam Patel, Baclofen-Induced Encephalopathy in End Stage Renal Disease,

Published on: March 4th, 2019

Updated on: June 3rd, 2020

About Author

Sharon Levy, MD, MPH

After successful graduation from Boston University, MA, Sharon gained a Master’s degree in Public Health. Since then, Sharon devoted herself entirely to the medical niche. Sharon Levy is also a certified addiction recovery coach.


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  • Joylena Williams
    This is very helpful educated name in ways that I never thought I could be thank you for all the good information and it clear on this thing I think God’s truck coming across this because I am on a lot of medication so I will be very careful I am 73 year old and I am still capable driving this is one thing I would like to keep doing taking care of myself running my own earring I thank you so much you all will be well and be blessed Joylena Williams.
  • Jeff
    I was prescribed Baclofen, Gabapentin, and Percosets together through my pain management. I stopped taking the gabapentin and they upped my dose to 10 mg oxycodone 3 x daily, 15 mg MS Contin 2x daily and 10 mg baclofen 3 x daily. I regularly hit my face on corners, walked into walls, reached for things that weren’t there. I remember dreaming that I couldn’t breathe, waking up struggling for breath. When I asked the pharmacist if this combination was safe, I was informed that at this doses, it would be extremely rare to have a problem. I feel like I’m lucky to be alive. I had a serious bicycle accident one year ago, multiple surgeries, etc…. I’ve been off all medications for one week now. The combinations felt deadly in retrospect.