Does Alcohol Kill Brain Cells? Alcohol and Brain Health

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For decades, research has been finding consistent evidence about the impact of alcohol consumption on brain structure and function.

A notable conclusion is the dose-dependent correlation between alcohol use and the reduction in right hippocampal volume, a critical region involved in memory and spatial navigation, which can be a significant contributor to 10-24% of dementia cases in nursing homes.

Excessive alcohol consumption is associated with reduced white matter, damage to brain cells, and inhibition of the creation of neurons and possibly results in a smaller brain. But does alcohol kill brain cells every time you drink? What part of the brain is significantly affected by alcohol consumption? Continue reading to learn about drinking alcohol and your brain health.

About the Brain

The human brain is one of the most complex organs, serving as the control hub for the body’s functions and cognitive processes. This specialized organ is divided into several major regions, each with distinct roles contributing to overall brain function.

The three main parts of the human brain are the:

  1. The cerebrum, the largest part of the brain, is responsible for higher cognitive functions.
  2. The cerebellum, located under the cerebrum at the back of the skull, is essential for motor control.
  3. The brainstem that connects the cerebrum with the spinal cord is crucial for maintaining basic life functions.

On a cellular level, the brain comprises neurons, glial cells, neural stem cells, and endothelial cells in charge of communication, signal transmission, support, protection, and neurogenesis. Studies suggest that alcohol can disrupt these functions and play a role in the development of alcohol dependence.

Does Drinking Alcohol Kill Brain Cells?

There is the belief that alcohol kills brain cells. While it’s true that alcohol disrupts the brain’s communication pathways, which can impact both its appearance and function, alcohol doesn’t kill brain cells per se, and there is no scientific evidence to support this claim.

Research shows that alcohol can damage dendrites in the cerebellum and reduce communication between neurons, leading to short-term effects like impaired judgment and slowed reaction times. But how does this happen?

How Does Alcohol Affect the Brain?

We clarified that alcohol does not directly “kill” neurons in the way toxins or trauma might. Instead, alcohol-induced brain damage results from a combination of factors, including oxidative stress, inflammation, and nutritional deficiencies.

Let’s get into detail on how alcohol affects the brain:

Damage to Brain Structure and Function

Damage to brain structure and function due to alcohol consumption can manifest in several significant ways, reflecting both the acute and chronic effects of alcohol on the central nervous system.

Here are some key aspects of how alcohol can damage brain structures and impair their functions:


Alcohol acts as a neurotoxin, a substance that disrupts the normal function of the brain. Alcohol exerts its neurotoxicity effects through oxidative stress, excitotoxicity, inflammation, nutritional deficiencies, and mitochondrial dysfunction, leading to neuronal cell death.

These effects are exacerbated in situations of binge drinking or chronic heavy consumption, where the levels of alcohol in the bloodstream are particularly high. Neuronal loss can be extensive, affecting multiple brain regions, including the cortex and hippocampus, critical for cognition, memory, and emotional regulation.

Brain Shrinkage (atrophy) and Volume Loss

Chronic alcohol abuse is associated with brain shrinkage and brain volume loss.

This is particularly visible in the frontal lobes, which are responsible for executive functions such as planning, controlling impulses, and complex decision-making. Brain imaging studies have shown that heavy drinkers often have reduced brain volume, which can correlate with cognitive deficits.

Can brain shrinkage from alcohol be reversed? Evidence shows shrinkage is partly reversible under alcohol abstinence. However, different brain areas recover at different rates, and higher cognitive functions take longer.

Changes in Cell Morphology

Chronic alcohol exposure can alter the structure of dendrites, the branch-like parts of neurons that receive signals from other neurons, disrupting neural communication.

Also, alcohol can inhibit neurogenesis, the process by which new neurons are formed in the brain. This mainly concerns the hippocampus, a region crucial for learning and memory, potentially leading to cognitive impairments.

Effects on Neurotransmitters

Alcohol influences neurotransmitter systems, including gamma-aminobutyric acid (GABA), glutamate, dopamine, and serotonin. These changes can affect mood, behavior, and cognitive functions. For instance, alcohol’s enhancement of GABA activity contributes to its sedative effects, while alterations in dopamine and serotonin pathways are associated with mood changes and addiction.

These changes in the brain are particularly important since the development of alcohol dependency, as well as dependency on other drugs of abuse, is believed to be mediated by alterations in brain chemistry. These changes lead to withdrawal symptoms when stopping alcohol use.

Wernicke-Korsakoff Syndrome

This syndrome is the one making people wonder: is wet brain reversible?

Wet brain is the colloquial term often used interchangeably with Wernicke-Korsakoff syndrome (WKS), a neurological disorder caused by a severe deficiency of thiamine (vitamin B1) and mainly caused by alcohol abuse. Since alcohol is a major risk factor for thiamine deficiency as it interferes with the absorption and utilization of thiamine by the body and poor diets, there is a high risk of developing this syndrome.

Take into account that WKS is not a single condition but rather two separate syndromes that often occur together:

  • Wernicke encephalopathy causes confusion, ataxia, and ocular abnormalities.
  • Korsakoff’s syndrome causes memory impairments (impairment forming memories or remembering)

If not treated quickly, Wernicke’s disease may advance to Korsakoff’s psychosis, an irreversible condition.

Impact on White Matter Integrity

Alcohol can damage the brain’s white matter, which consists of myelinated nerve fibers that connect different brain regions.

This white matter damage disrupts the efficient transmission of electrical signals across the brain, affecting cognitive functions and slowing down processing speed. Diffuse white matter degradation can lead to significant brain function impairments, including memory, attention, and executive functioning problems.

Alcohol-Related Brain Damage (ARBD)

Alcohol-related brain Damage (ARBD) refers to a spectrum of long-term brain conditions associated with chronic alcohol abuse.

ARBD encompasses various disorders, including Wernicke-Korsakoff Syndrome, alcoholic dementia, and other cognitive impairments. These conditions can affect memory, learning, cognitive skills, and emotional and behavioral control. While some symptoms of ARBD can improve with abstinence and appropriate treatment, particularly in the early stages, others may be permanent.

Hepatic Encephalopathy

Hepatic encephalopathy is a complication of liver disease, particularly in alcoholics with cirrhosis, which occurs when the liver is unable to remove toxins from the blood, leading to a buildup of these toxins in the bloodstream.

The condition can manifest in a wide range of symptoms, from minor signs like confusion and personality changes to severe complications such as coma. Hepatic encephalopathy is often reversible with proper treatment, primarily focusing on reducing toxins in the bloodstream, typically by addressing the underlying liver dysfunction and managing the symptoms.

Fetal Alcohol Spectrum Disorder (FASD)

Exposure to alcohol in utero can lead to FASD, a range of effects that can occur in an individual whose mother consumed alcohol during pregnancy. The most severe form of FASD is Fetal Alcohol Syndrome (FAS), which is characterized by growth deficiencies, facial abnormalities, and central nervous system problems.

Prenatal alcohol exposure is associated with an increased risk of various birth outcomes, including stillbirths, miscarriage, and sudden infant death syndrome. In cases where the baby survives, some developmental disorders can still occur.

Does Drinking Kill Brain Cells? Alcohol Consumption in Minors

Apart from the legal consequences, drinking alcohol during childhood and teenage years can lead to significant differences in structure and function in the developing human brain. The brain is still maturing during this time, and any interference with this process can lead to permanent damage.

Given the lack of concrete studies pinpointing how much alcohol it takes to cause these adverse effects in the developing brains of children, the safest approach is to avoid alcohol altogether. The risk is especially high for children under 15 years of age, yet it’s strongly encouraged to postpone drinking for as long as possible.

Does Alcohol Permanently Damage The Brain?

One of the most outstanding characteristics of the brain is the ability to change and adapt in response to experiences, including injury. Brain plasticity suggests that, to some extent, recovery from alcohol-induced damage can occur if the alcohol abuse is stopped.

Yet, alcohol can permanently damage the brain. The amount of damage depends on several factors, including age, gender, nutrition, and overall alcohol consumption. Younger people have a better chance of recovery, and cognitive recovery can take up to 12 months after stopping drinking. However, for many people, the effects of alcohol-related brain impairment (ARBI) can be permanent.

Does Alcohol Kill Brain Cells? − Bottom Line

Heavy alcohol use can lead to neurodegeneration and a progressive inability to control drinking. The brain changes associated with addiction not only fuel the dependence but also make it harder for individuals with Alcohol Use Disorder (AUD) to alter their drinking habits, especially when managing alcohol withdrawal symptoms.

The proper support and treatment can help the brain’s remarkable ability to recover some of the cognitive functions affected by alcohol. Yet, this recovery is more likely to be successful with early intervention and in an environment that promotes healthy behaviors and mental stimulation.

If you or someone you know is struggling with AUD, seek professional help for a long-term strategy for improvement.

People Also Ask

Can alcohol poisoning cause brain damage?

Yes, severe alcohol poisoning can damage brain cells and lead to long-term problems like memory issues and long-term cognitive impairments.

Does alcohol destroy brain cells?

Excessive alcohol can damage brain structure and function, but it doesn’t directly kill brain cells. It affects the dendrites, leading to communication issues among neurons.

How does alcohol kill you?

Alcohol can fatally disrupt body functions by poisoning organs, causing accidents due to impaired judgment, or leading to long-term health issues like liver disease, which can result in death.

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Published on: March 9th, 2018

Updated on: May 24th, 2024


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