Carisoprodol Interactions With Alcohol, Drugs, And Food

Last Updated: June 3, 2020

Authored by Roger Weiss, MD

Carisoprodol interactions may range from minor to life-threatening. This muscle relaxant – sold with brand names Soprodol, Vanadom, and Soma – may lead to profound depression of the central nervous system and respiratory distress if combined with drugs that potentiate its effects. Physicians and patients should be aware of these carisoprodol drug interactions and its abuse potential to know what caution should be taken when alternatives can be used, and what drug combinations should be avoided.

Drugs That Cause Severe Soma Interactions

Doctors may only allow such combinations if necessary, and other treatments are inadequate.

  • Soma with Codeine: Using codeine and carisoprodol may increase the risk of the profound central nervous system (CNS) and respiratory depression, leading to coma and respiratory failure, respectively.
  • Soma and Hydrocodone: Soma Hydrocodone combinations should be avoided because of a high risk of profound CNS depression, respiratory failure, and death.
  • Soma and Vicodin: Vicodin is a combination of hydrocodone and Acetaminophen. A mixture of Soma and Vicodin increases the toxicity of the other. This combination should be avoided because of the high risk of CNS depression and respiratory failure.
  • Soma and Oxycodone: A combination of Soma and Oxycodone may cause coma, respiratory depression, and death. It may also increase the addictive effects of both drugs if they are taken in large doses or for long durations.
  • Soma and Clopidogrel: Avoid this combination because clopidogrel increases the blood levels of carisoprodol, amplifying its adverse effects.
  • Carisoprodol and Meprobamate: This combination increases the risk of CNS depression and psychomotor impairment. It also increases Vanadom’s additive effects, since it is converted to meprobamate in the blood.
  • Carisoprodol and Promethazine: This combination increases the risk of loss of consciousness and respiratory depression. It also increases the additive effects of Soprodol.
  • Carisoprodol and Sodium Oxybate: Using Carisoprodol and sodium oxybate increases the risk of coma and psychomotor impairment.

For these medicines, doctors may prescribe an alternative such as cyclobenzaprine. Cyclobenzaprine vs Soma: Unlike carisoprodol, cyclobenzaprine has an opioid-sparing effect when used with opioid medications, and its abuse potential is not as severe as with Soma.

diferent medications taken together

Drugs That Cause Serious Carisoprodol Interactions

  • Soma and Valium: Using carisoprodol with diazepam increases the sedative effects of both medicines.
  • Soma and Ambien: Carisoprodol and Ambien, when taken together, increase the sedative effects of both drugs. It also increases the risk of CNS depression and respiratory depression when used in high doses.
  • Vanadom and Xanax: Xanax and Soma can be combined in small doses and used for short durations. However, this combination increases sedation if used for long.
  • Soprodol and Tramadol: Soma and Tramadol both increase sedation. When taken at high doses, both drugs can increase the risk of CNS depression and coma.
  • Vanadom and Chlorpromazine: Taking this combo increases sedation and may cause severe CNS depression and coma if taken together at high doses.
  • Carisoprodol and Methadone: Taking a combination of soma and methadone may increase risk of severe CNS depression and respiratory depression unless combined in the lowest effective doses and used for the shortest duration.
  • Carisoprodol and Buprenorphine: This combo may increase the risk of CNS depression and respiratory depression. So, one should consult the doctor before taking a combination of Suboxone and soma.

Moderate Drug Interactions

The following drug combinations may cause minimal or moderate clinical effects if used with caution. However, prolonged use or use at much higher doses may increase the risk of severe reactions.

  • Vanadom and Amitriptyline: This combo may increase the sedation. In much larger doses, however, there may be CNS depression and increased addictive effects.
  • Carisoprodol and Gabapentin: Taking gabapentin and soma can worsen the sedative effects of both drugs. It may also amplify the addictive effects of Vanadom if used at much higher doses than recommended.
  • Soma and Ketamine: A combination of soma and ketamine may worsen sedation and also increase the risk of CNS depression.
  • Carisoprodol and Trazodone: This combo also increases sedation and psychomotor impairment.
  • Carisoprodol and Pregabalin: Pregabalin increases the addictive effects of carisoprodol.
  • Vanadom and Phenytoin: Phenytoin may increase the breakdown of carisoprodol, increasing the amount of its metabolite, meprobamate, in the system per time. This may amplify the severity of its side effects.
  • Vanadom and Omeprazole: Omeprazole inhibits the breakdown of the drug in the liver, thereby, prolonging its stay in the system. This causes the increased duration of its CNS effects and may also extend its presence in soma drug tests much longer after its use.

Soma Coma and Houston Cocktail

Vanadom is one of the drugs of abuse whose effects occur very fast and last for a relatively long time. It is used in many different combinations, and since soma pill street value is low, it is very cheap to get. Many users take it in conjunction with other drugs to increase its euphoric effects. Some of these combinations have been given street names such as “Holy Trinity” and “Soma coma.”

pills in cocktail galss

A combination of alprazolam, soma, and hydrocodone often used for recreational purposes is called the “Houston Cocktail” or “Holy Trinity”. Another mix for recreational use is with codeine – a combination called soma coma.

These combinations increase the risk of overdose symptoms, such as respiratory depression, fast heart rate, coma, and even death. These combinations often result in thousands of admissions into emergency rooms.

Alcohol And Carisoprodol

A combination of soma and alcohol is not recommended and should be avoided. Some people take a soma alcohol mixture to amplify its relaxing effect or the soma high they get from the drug. While the results may feel pleasant at first, the impact on the brain and other organ systems can be devastating.

Since both drugs act on the brain, each potentiates the effect of the other. This amplifies the effects of carisoprodol on the brain, causing severe drowsiness and disorientation. At large doses, it may increase the risk of overdose symptoms, including a sudden drop in blood pressure or shock, dangerously fast heart rates, respiratory depression, and death.

Besides, since alcohol dependence comes with nutritional deficiencies, it may also worsen soma weight loss effects.

Food Interactions With Soma

There are no food restrictions when using Soma (except alcohol avoidance). However, it may have minor reactions with eucalyptus and sage. These herbs may increase the sedative effects of carisoprodol when used together. However, this interaction is minor and should not preclude these combinations.

Preventing Carisoprodol Drug Interactions

To avoid these carisoprodol interactionsit is important to follow prescri ption instructions and read prescription labels regarding carisoprodol dosage and use. As a result of its abuse and addictive tendencies, the drug has been under tight regulation.

Is Soma a controlled substance? Yes, it is classified as a Schedule IV controlled substance. This keeps a close regulation on how it is prescribed and consumed, to prevent abuse and the risk of overdose from the drug. Treatment of drug addiction requires even more attention. Drug rehabilitation facilities offer various programs for those who need help.

Page Sources

  1. Zacny JP, Paice JA, Coalson DW, Subjective and psychomotor effects of carisoprodol in combination with oxycodone in healthy volunteers,
  2. Tse SA, Atayee RS, Ma JD, Best BM, Factors affecting carisoprodol metabolism in pain patients using urinary excretion data,
  3. Moody DE, Fu Y, Fang WB, Inhibition of In Vitro Metabolism of Opioids by Skeletal Muscle Relaxants,

Published on: June 7th, 2019

Updated on: June 3rd, 2020

About Author

Roger Weiss, MD

Dr. Roger Weiss is a practicing mental health specialist at the hospital. Dr. Weiss combines his clinical practice and medical writing career since 2009. Apart from these activities, Dr. Weiss also delivers lectures for youth, former addicts, and everyone interested in topics such as substance abuse and treatment.


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