Carisoprodol Interactions With Drugs and Alcohol

Last Updated: August 31, 2021

Authored by Roger Weiss, MD

Reviewed by Michael Espelin APRN

Carisoprodol interactions may range from minor to life-threatening. This muscle relaxant – sold with brand name Soma – may lead to profound depression of the central nervous system and respiratory distress if combined with drugs that potentiate its effects. Examples of such dangerous interactions are Soma and Hydrocodone or Xanax and Soma. When these three drugs are mixed to make a Houston Cocktail, they pose a very significant risk. This mix has contributed to many overdose deaths in the US. Physicians and patients should be aware of these Carisoprodol drug interactions and their abuse potential to know when to take caution, use alternatives, and what drug combinations to avoid.

Soma and Hydrocodone

Soma is a muscle relaxant used to relieve musculoskeletal pain. It is a fact that people who need to relax their muscles also feel pain. That said, Hydrocodone is commonly used alongside.

Some reports have shown that the effects of Carisoprodol drug reduce when Soma and Hydrocodone are taken together. Additionally, this combination subjects the individual to abuse. As a result, abuse of the mixture of Soma and Hydrocodone is prevalent in many places worldwide. It happens due to both accidental and deliberate intentions.

Two prescription bottles of Soma and Hydrocodone spilling pills.

Other opioids like Oxycodone and Morphine are also taken in combination with this drug among addicted individuals. Heavy consumption over time can lead to multiple health complications and life-threatening conditions. These health complications include respiratory difficulties and disruption of homeostasis. Mixing opioids and muscle relaxants cause a higher risk of experiencing an opioid overdose.

Carisoprodol interactions with any other opioid are just as dangerous. The only exception to this is the mixture of this drug with Codeine. In fact, this drug is commonly taken with Codeine. If more is taken, it can lead to respiratory difficulties, which could lead to death.

Xanax and Soma

Xanax, also called alprazolam, is a benzodiazepine used to calm people with anxiety and panic disorders. However, when Xanax and Soma are combined, it encourages adverse side effects like drowsiness, lightheadedness, and concentration challenges. Older people have also been reported to have difficulties in cognitive and motor coordination functions when they accidentally combine Xanax and Soma.

Ambien and Soma

Ambien is a medication commonly used by people who face sleeping problems. Typically, Ambien, also called Zolpidem, provides some minor side effects such as drowsiness and sleepiness. Carisoprodol interactions with Zolpidem can amplify this effect. Some other side effects include cognitive and motor coordination difficulties.

Carisoprodol Interactions With Alcohol

A Soma alcohol combination is not recommended and should be avoided. Some people take a Soma alcohol mixture to amplify the relaxing effect they get from the drug. While the results may feel pleasant at first, the impact on the brain and other organ systems can be devastating.

Since both drugs act on the brain, each potentiates the effect of the other. It can result in severe drowsiness and disorientation. In addition, it may increase the chance of overdose symptoms at large dosages, including a sudden drop in blood pressure or shock, dangerously fast heart rates, respiratory depression, and death.

Woman feeling dizzy after taking Soma alcohol mix.

Long-term effects of this combination include severe cardiac damage, kidney damage, slurred speech, damage to the spinal cord causing total paralysis, blindness, and cognitive decline such as memory loss.

Besides, since alcohol dependence comes with nutritional deficiencies, it may also worsen Soma weight loss effects.

Serious Soma Drug Interactions

Taking Carisoprodol in the following combinations can cause serious effects. Therefore, taking these combinations requires strict monitoring by physicians or the use of alternative medication.

Doctors may only allow such combinations if necessary, and other treatments are inadequate.

  • Soma and Vicodin: Vicodin is a combination of Hydrocodone and Acetaminophen. Because Soma and Hydrocodone are not a good combination, using it with Vicodin is also dangerous.
  • Oxycodone: Oxycodone is a potent opioid. A combination of Soma and Oxycodone may cause coma, respiratory depression, and death. Carisoprodol interactions may also increase the addictive effects of both drugs if they are taken in large doses or for long durations.
  • Carisoprodol and Methadone: Taking a combination of this drug and methadone may increase the chance of severe CNS depression and respiratory depression unless combined in the lowest effective doses and used for the shortest duration.
  • Buprenorphine: This combo may increase the chance of CNS depression and respiratory depression. So, one should consult the doctor before taking a combination of Suboxone and this drug.
  • Clopidogrel: Avoid this combination because clopidogrel increases the blood levels of this drug, amplifying its adverse effects.
  • Meprobamate: This combination increases the chance of CNS depression and psychomotor impairment. It also increases Vanadom’s additive effects since it is converted to meprobamate in the blood.
  • Promethazine: This combination increases the risk of loss of consciousness and respiratory depression. It also increases the additive effects of Soprodol.
  • Sodium Oxybate: Using this drug and sodium oxybate increases the risk of coma and psychomotor impairment.

For these medicines, doctors may prescribe an alternative such as cyclobenzaprine. Comparing Cyclobenzaprine vs. Soma, cyclobenzaprine has an opioid-sparing effect when used with opioid medications, and its abuse potential is not as severe as with this drug.

Moderate Soma Interactions

The following drug combinations may cause minimal or moderate clinical effects if used with caution. However, prolonged use or use at much higher doses may increase the risk of severe reactions.

The Moderate Interactions Include:

  • Amitriptyline: This combo may increase sedation. In much larger doses, however, there may be CNS depression and increased addictive effects.
  • Gabapentin: Taking gabapentin and this Carisoprodol can worsen the sedative effects of both drugs. It may also amplify the addictive effects of this Carisoprodol if used at much higher doses than recommended.
  • Ketamine: A combination of this drug and ketamine may worsen sedation and increase the risk of CNS depression.
  • Trazodone: This combo also increases sedation and psychomotor impairment.
  • Pregabalin: Pregabalin increases the addictive effects of this drug.
  • Phenytoin: Phenytoin may increase the breakdown of Carisoprodol, increasing the amount of its metabolite, meprobamate, in the system per time. This may amplify the severity of its side effects.
  • Omeprazole: Omeprazole inhibits the breakdown of the drug in the liver, thereby prolonging its stay in the system. It causes the increased duration of its CNS effects and may extend its presence in Soma drug tests much longer after its use.

Houston Cocktail

Carisoprodol is one of the drugs of abuse whose effects occur very fast and lasts for a relatively long time. It is used in many different combinations. Many users take it in conjunction with other drugs to increase its euphoric effects.

These combinations increase the risk of overdose symptoms, such as respiratory depression, fast heart rate, coma, and even death. They often result in thousands of admissions into emergency rooms.

The demographic for this hybrid danger drug are young and middle-aged adults. Between 2015 and 2019, 80 people were recorded to be driving under the influence of a mixture of hydrocodone, alprazolam and Carisoprodol. The mean age of these drivers was about 34 years. As expected, these drivers showed massive signs of cognitive difficulties, which affected their driving. In addition, many ingestions of this combo were reported to poison centers. Between 1998 and 2009 there were 1295 cases reported to Texas poison centers.

Preventing Carisoprodol Drug Interactions

Carisoprodol interacts differently with different forms of substances to produce different reactions. Three of the most Soma drug interactions are its combination with Hydrocodone, Ambien, and Xanax. Other dangerous Soma drug interactions include Carisoprodol and Vicodin, alcohol, and methadone. Consumption of these combinations could lead to some severe side effects.

In cases of Soma addiction, drug rehabilitation facilities and professional medical consultations are the best options. Failure to treat the addiction would lead the user to life-threatening situations.

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Page Sources

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Published on: June 7th, 2019

Updated on: August 31st, 2021

About Author

Roger Weiss, MD

Dr. Roger Weiss is a practicing mental health specialist at the hospital. Dr. Weiss combines his clinical practice and medical writing career since 2009. Apart from these activities, Dr. Weiss also delivers lectures for youth, former addicts, and everyone interested in topics such as substance abuse and treatment.

Medically Reviewed by

Michael Espelin APRN

8 years of nursing experience in wide variety of behavioral and addition settings that include adult inpatient and outpatient mental health services with substance use disorders, and geriatric long-term care and hospice care.  He has a particular interest in psychopharmacology, nutritional psychiatry, and alternative treatment options involving particular vitamins, dietary supplements, and administering auricular acupuncture.