Quetiapine Interactions: Can One Take Alcohol and Seroquel?

Last Updated: June 10, 2020

Seroquel belongs to the class of antipsychotic drugs that are used to treat schizophrenia, bipolar disorder, and other mental illnesses. Like all medicines, Quetiapine interactions can  occur with certain medications and substances. Read along further to find out about the interactions of Quetiapine and alcohol, other Seroquel drug interactions, and how to use it safely to avoid these dangerous Seroquel interactions.

Seroquel And Alcohol Interactions

Since the Seroquel pill is prescribed for certain mental illnesses to improve one’s mood, sleep, and self-esteem, some patients might combine it with alcohol to enhance its effects. However, according to the guidelines of the Food and Drug Administration, alcohol should not be consumed while taking Quetiapine as it can worsen the side effects.
Depressed woman is drinking red wine and taking pills.
Drinking on Seroquel can affect the way the body metabolizes Quetiapine and can make even small amounts of the medicine more potent. This can result in the worsening of its side effects. Both of these substances can cause the effect of each other to increase, which can result in a dangerous overdose condition.

Seroquel Interactions With Illicit Substances

Apart from alcohol, Quetiapine has been shown to have interactions with certain other substances. Patients who take Seroquel for anxiety might try to combine it with other illicit substances to enhance its effects. However, this combination can cause serious side effects, which can even prove to be fatal. Some of the interactions of Quetiapine with other substances are described in the following sections.

Seroquel And Weed

The use of weed with Quetiapine can increase side effects such as dizziness, drowsiness, confusion, and difficulty in thinking. Seroquel and weed can also cause impaired judgment and difficulties in motor coordination in some individuals, especially the elderly. The ingestion, inhalation, or smoking of any of these drugs can increase the risks of the mental illness for which Quetiapine is being taken, or it may cause a relapse in the condition.
Cocaine, dried hemp and Quetiapine.

Seroquel And Cocaine

When cocaine is used while taking Seroquel, it can increase the side effects of Quetiapine even when taken on low doses. The most commonly experienced side effects which can worsen include dizziness, drowsiness, and difficulty in concentrating.

Seroquel Drug Interactions

Certain medications, when taken together, can have a negative effect on the patient’s body and can even possibly cause dangerous interactions. When one is taking Quetiapine, caution should be exercised since it can cause interactions with several other drugs. These Quetiapine interactions with other drugs are described in detail in the next sections.

Quetiapine Interactions With Benzodiazepines

Benzodiazepines are a class of medication that is used to treat conditions such as anxiety and insomnia. They work by having a sedative effect on the central nervous system. Such medicines that can cause drowsiness and sleepiness can worsen these effects when taken with Seroquel.
Seroquel and Xanax (which belongs to benzodiazepines), when taken together, can interact with each other and cause dangerous side effects such as the worsening of dizziness, drowsiness, and sleepiness.

Quetiapine also interacts with other benzodiazepines such as Klonopin and Valium. When Seroquel and Klonopin are taken together, it can cause dangerous interactions by worsening the side effects of drowsiness and dizziness. The same kind of interaction is observed in the case of taking Seroquel and valium together.
Ativan is another benzodiazepine, which, when mixed with Quetiapine, can cause dangerous interactions. The combination with Ativan can cause excessive sedation, confusion, dizziness, and lack of coordination that can put the patient’s life and the lives of other people around him at risk.

Seroquel and benzodiazepines interactions.

Quetiapine Interactions With SNRIs

SNRIs (Serotonin-norepinephrine reuptake inhibitors) are a class of antidepressant drugs that are used to treat different types of depressive disorders, including anxiety, OCD, social phobia, ADHD, and depression along with the treatment of long-term, chronic pain. They work by affecting brain chemistry and help to regulate mood. Seroquel mechanism of action is relatively similar since it also works by restoring the balance of neurotransmitters in the brain.
According to this study about Quetiapine augmentation in depressed patients on SNRIs, it showed an improvement in depression when Quetiapine was combined together with SNRIs. Cymbalta and Seroquel, when taken together, complement each other well with mild interactions. The side effects of sleepiness and drowsiness may increase a bit, but not to that extent, which can become dangerous. However, in some cases, this combination of Seroquel and Cymbalta can cause serious interactions.
When Seroquel and Effexor are taken together, they can increase the risk of an irregular heart rhythm that can be quite serious. Although it is a rare side effect, the possibility of such a dangerous interaction is present.

Quetiapine Interactions With Antipsychotics

Quetiapine itself belongs to the antipsychotic drug class. Sometimes, patients might combine Seroquel with other antipsychotic drugs to enhance antidepressant effects. Certain antipsychotic drugs can safely be combined with Quetiapine for the treatment of various disorders. According to this research about the combination of Abilify and Seroquel for treating patients of schizophrenia, the results concluded that the combination was well-tolerated and generally safe.
SSRI tablets of different colors
Taking Zyprexa and Seroquel together can result in a slight worsening of the side effects, including weight gain. A doctor may prescribe these two medications together if he believes that the patient will benefit from this combination as compared to taking any of them alone. However, losing weight on Seroquel and a combination with another antipsychotic drug can become a challenging task.

Quetiapine Interactions With SSRIs

SSRIs are selective serotonin reuptake inhibitors that are used as antidepressants for the treatment of various depressive and anxiety disorders. SSRIs work by increasing the levels of serotonin (a neurotransmitter) in the brain. Through recent studies and research, it is shown that combining quetiapine with SSRIs can prove to be beneficial in treating neuropsychiatric conditions such as depression and schizophrenia.
An extensive study was carried out to determine the safety and efficacy of using quetiapine with SSRIs on patients of major depressive disorders. Through this study, it was concluded that quetiapine and SSRIs are well-tolerated, and no significant drug interactions were found:

  • When Zoloft and Seroquel are combined together for the treatment of depression, no dangerous interactions are noted, and the combination is well-tolerated.
  • Similarly, Lexapro and Seroquel can also be combined safely for the treatment of depression and other depressive disorders.
  • Seroquel and Prozac (another SSRI) do not show any significant interactions and have been shown to be combined safely according to the doctor’s prescription.
  • When Seroquel and Celexa are combined together or when Paxil and Seroquel are augmented together for the treatment of schizophrenia, depression, or other mental disorders, they have been shown to work quite well together with no severe interactions.
  • Taking Trazodone and Seroquel together can cause a worsening in the side effects, especially dizziness and drowsiness. With this combination, Seroquel headache occurrences are also increased. In rare conditions, taking these two medications together can increase the risk of cardiac problems.

Other Seroquel Interactions

Quetiapine drug interactions can appear with certain other drugs as well. Some of these interactions may be mild and can be well-tolerated if Seroquel XR dosages and the doses of other medications are taken as prescribed by the doctor. However, in some cases, drug interactions of Seroquel with other medicines may be severe, which should be avoided entirely.
Tablets pills and capsules which interact with Quetiapine.
Some of the medicines that cause mild or no drug interactions when used with Quetiapine are listed below:

  • Lamictal is an anticonvulsant medication that is used to treat epilepsy, seizures, and bipolar disorders. Combining Lamictal and Seroquel together for the treatment of these disorders has shown to improve the treatment success and are both well-tolerated together.
  • Ambien belongs to the class of drugs called sedatives that are used to treat sleep problems and insomnia. Taking Seroquel and Ambien together does not cause any significant interactions and is well tolerated.
  • Depakote is a type of medication used for the treatment of epilepsy, seizures, bipolar disorder, and migraine headaches. Depakote and Seroquel can be taken together for the treatment of bipolar disorder with no negative interactions.
  • Wellbutrin is an antidepressant drug. When Seroquel and Wellbutrin are combined together, they may increase the risk of seizures, but that is a rare side effect. Taking one of these drugs in the AM and the other in the PM has been shown to cause no significant interactions.

Some of the serious Quetiapine drug interactions with other medicines are further described below:

Seroquel And Adderall

Adderall belongs to the drug class called stimulants, whose objective is to boost dopamine levels. Quetiapine, on the other hand, is an antagonist of serotonin and dopamine. Thus, both Seroquel and Adderall are opposites of each other. Taking them both together can cause severe interactions since both will be working to negate the other’s effect and can send the brain transmitters into a frenzy.

Lithium And Seroquel

Lithium is commonly used for the treatment of manic depressive disorders and bipolar disorders. When lithium and Seroquel are combined together, it can cause serious drug interactions. It can lead to delirium and acute lithium intoxication, which can be avoided by not taking these medicines together.

Seroquel And Benadryl

Benadryl is an antihistamine that is used to treat allergies and to induce sleep. Since Seroquel also causes drowsiness and sleepiness, taking Seroquel and Benadryl together can worsen the side effects and cause dangerous interactions. Severe side effects such as dizziness, dry mouth, reduced heart rate, confusion, blurred vision, and fever may occur.

Tramadol and Seroquel

Tramadol is an opioid that is used for chronic pain medication. Taking tramadol and Seroquel together can cause serious interactions resulting in severe side effects such as seizures, respiratory distress, coma, and even death. Similarly, Methadone is also an opioid. Taking Seroquel and methadone together can cause serious drug interactions and should be avoided. It can cause increased sedation and a dangerously slow heart rate.

Seroquel And Caffeine

Caffeine has been shown to interact with certain drugs. However, Quetiapine has not been established to be one of them.

Avoiding Dangerous Seroquel Interactions

Seroquel works well with some medicines, whereas it can cause serious drug interactions with others. The combined effects of some medicines with Seroquel can cause an overdose of Seroquel that could result in severe side effects.

Quetiapine should always be taken according to the dosage prescribed by the doctor. Some people abuse it also by crushing and snorting Seroquel pills. This behavior can increase the risk of overdosing and should be avoided. Snorting or taking large doses of quetiapine may be a sign of addiction to this drug. This condition should be examined by an addiction treatment expert as soon as possible. If it takes place in a patient, they will be sent to a rehabilitation facility where they will get help to overcome the addiction successfully.

Page Sources

  1. Olver JS, Ignatiadis S, Maruff P, Burrows GD, Norman TR, Quetiapine augmentation in depressed patients with partial response to antidepressants, Dec 2008, https://www.ncbi.nlm.nih.gov/pubmed/18816504
  2. Kane JM, Correll CU, Goff DC, Kirkpatrick B, Marder SR, Vester-Blockland E, Sun W, Carson WH, Pikalov A, Assuncao-Talbott S, A multicenter, randomized, double-blind, placebo-controlled, 16-week study of adjunctive aripiprazole for schizophrenia or schizoaffective disorder inadequately treated with quetiapine or risperidone monotherapy, Oct 2009, https://www.ncbi.nlm.nih.gov/pubmed/19906340
  3. John D. Matthews, Seroquel Alone Versus Seroquel With an SSRI for Depression With Psychotic Symptoms (Seroquel)б https://clinicaltrials.gov/ct2/show/NCT00955474

Published on: February 19th, 2020

Updated on: June 10th, 2020


Leave a comment