Seroquel Withdrawal: How To Discontinue Seroquel Safely?

Last Updated: June 12, 2020

Seroquel has the active ingredient quetiapine and is most often administered as an antipsychotic. The drug exerts several effects on the human central nervous system, largely in the 5-HT2A, 5-HT1A receptors, and other parts of the brain. Stopping Seroquel abruptly may lead to serious health issues by affecting the distribution of major neurotransmitters in the brain. Seroquel withdrawal symptoms can be extreme and pose a risk to wellbeing.
Some individuals may experience different levels of withdrawal from Seroquel due to particular health conditions. The concern with Seroquel withdrawal is that many individuals try to get off the drug without proper consultation with a medical professional, and this often goes wrong. There are significant risks connected with stopping Seroquel abruptly, especially for those who may be using very high doses of this medication.  There are several options to Seroquel discontinuation that will ensure the patient safely gets off the drug with minimal to no side effects.

Stopping Seroquel Cold Turkey

Quitting Seroquel can be difficult because this medication is highly potent and affects major CNS functions. The regulation of neurotransmitters and levels of dopamine, histamine, serotonin, and norepinephrine is greatly affected. This can be dangerous when a person decides to stop Seroquel cold turkey. It is even more dangerous if one has been using Quetiapine (Seroquel) with other substances such as alcohol or other medications, which are likely to increase the effect of the medication.
Woman holding hands on her stomach.
Quetiapine side effects can be quite intense, especially for those who may have developed a tolerance for high doses. Seroquel withdrawal cold turkey affects brain functions, creating a sudden disruption in an established system.

Dangers Of Stopping Seroquel Cold Turkey

In many cases weaning off Seroquel is the best way to avoid the health risks that come with withdrawal symptoms. Tapering off Seroquel helps to keep a fairly constant internal environment, ensuring that the brain continually receives a substantial amount or concentration of the substances that it has gotten accustomed to. Quitting the habit should never be immediate. The level of risk also depends on the dosage that the individual has been placed on overtime.  Medication can be tapered from the current dosage to the lowest form in sequences stretched over a period of days, weeks, or months. Seroquel 25 mg is the lowest dosage form for immediate release. Seroquel taper schedule should be recommended by a qualified physician. Risks associated with quitting the drug cold turkey include:

  • Stroke
  • Liver failure
  • Nausea
  • Diarrhea
  • Susceptibility to cataracts
  • Low and high blood pressure
  • Leukemia
  • Palpitations
  • High risk for people with a history of heart problems

How Should One Taper Off Seroquel?

Here is how to taper off Seroquel: A doctor should create a tailored Seroquel XR withdrawal schedule to wean off the drug and to prevent relapse. To do this, the doctor assesses the current dosing and the tolerance level of the patient. For instance, a patient who has been on 300 mg daily may have to cut down the dose drastically to 50 mg per week, this is entirely up to the physician, after proper medical analysis of the patient’s condition. This change in medication will likely cause the development of limited withdrawal symptoms; however, it is imperative to stick to the drug schedule.

Seroquel Withdrawal Symptoms

Queries on how to deal with Seroquel withdrawal are numerous as users find themselves conflicted on how best to get off the medication without health implications. Many people experience withdrawals from Seroquel due to unsupervised methods of tapering or stopping cold turkey. Some individuals may try to get off the medication by concomitant use with other drugs; this can cause some unwanted Seroquel drug interactions.
Depressed man suffering from Seroquel withdrawal symptoms.
Generally, coming off Seroquel once the withdrawal symptoms begin, can be quite a challenge. The medication acts as a sedative and is also administered for schizophrenia in individuals above the age of 13. Quetiapine for sleep, bipolar disorder, and other mental health issues can be highly effective. However, the downside is the possible withdrawal symptoms that the patient might likely experience. Seroquel withdrawal side effects include:

  • Itchy red skin
  • Heart failure
  • Vomiting
  • Insomnia
  • Shortness of breath
  • Inflamed stomach
  • Brain shocks
  • Dehydration
  • Fatigue
  • High anxiety
  • Depression and suicidal thoughts
  • Rapid Weight loss/ weight gain
  • Difficulty in seeing
  • Kidney problems
  • Low libido
  • Hallucinations
  • Low appetite
  • Loss of strength
  • Joint pains
  • Swellings in the body caused by a build-up of fluids
  • Frequent urination
  • headaches

Factors That Can Influence The Severity Of Seroquel Withdrawal Symptoms

Seroquel withdrawals have increased risks under certain conditions. Since the approval of the drug as a medication for certain mental health problems, there have been controversies on its applications in mental health. This dilemma has led to warnings by the FDA on the prescription medication as there are health conditions that may escalate the effects of the drug, leading to complications. There are two major warnings on the usage of the medication, they are specific black box cautions on administration, and they include:


The FDA advised against the use of Seroquel by the elderly who have been diagnosed with dementia, as the drug has been known to cause severe withdrawal symptoms, even while on a tapering schedule. The medication may also cause poor memory, rapid change in mood and personality, as well as confusion. The medication can be fatal to those with dementia.
Senior Man Suffering With Quetiapine withdrawal signs.


The efficacy and safety of the medication in younger children are inconclusive. Experts do not recommend this medication for children younger than 13 years of age. The medication greatly affects the CNS and brings about a feeling of depression, low self-worth, and suicidal behaviors, especially among individuals who are younger than 24 years in age.

Interactions With Other Substances

Concomitant use of quetiapine with other drugs may lead to serious health risks during withdrawals. They may influence Seroquel metabolism and elimination from the body.
Substances such as alcohol may increase the potency of the medication, and this can result in heavy sedation or worse conditions.

How Long Does Seroquel Withdrawal Last?

There are people who experience extended quetiapine withdrawal symptoms, while some others may have very brief experiences. Quetiapine withdrawal time may depend on a few factors, such as the length of time that the patient had used the medication for, as well as the dosages. The Seroquel withdrawal timeline often becomes problematic because of the initial administration of the drug and the method used to taper off the drug.
Woman's hand marking Seroquel withdrawal timeline end.
Typically, the medication is administered in such a way that it builds up from a low level to a higher level of concentration to achieve a stable dose in the body. This method of administration is essential due to the chemistry of the brain. Individuals who do not follow this pattern usually go for a high dosage on the first encounter, and a rapid dependence on the medication is formed. This leads to frequent abuse as tolerance increases. The time taken before a patient begins to feel withdrawal symptoms shorten. On average, it takes up to 14 days for withdrawal signs to disappear in a person.
The half-life of Seroquel plays a major role in the withdrawal timeline. The withdrawal timeline varies, but typically lasts for about three to twelve weeks. Some patients can experience Seroqeul withdrawals even longer. This depends on the dosage and duration of administration. Seroquel withdrawal symptoms timeline is best suggested by a doctor, for effective monitoring and to alleviate the distress.

Best Supplements To Manage Seroquel Withdrawals

Withdrawals from Seroquel can take a toll on mental health. Often times, pharmaceuticals alone are not enough to calm the panic and anxiety induced by withdrawal symptoms. Another way to calm the body and improve mental balance is to seek supplements that can augment naturally.
Writing a list of supplements for seroquel withdrawal.
Here are a few supplements that may be helpful in managing Seroquel withdrawals:

  • Vitamin B complex
  • Vitamin D
  • Magnesium
  • Vitamin C
  • Calcium
  • Melatonin
  • L-Tyrosine/L-Phenylalanine

Vitamin B complex

Vitamin B3 enables tryptophan conversion, and B6 converts 5 HTP to serotonin, which is regulated in the brain. An adequate supply of Vitamin B3, B12, and B6 can energize the body and alleviate Seroquel withdrawal fatigue.


An increase in magnesium intake while stopping Seroquel can help to calm the mood, relieve mental stress, and can be instrumental for anxiety, insomnia, and depression. When the body is low in magnesium, the system is unable to absorb Vitamin D, which is an essential vitamin for the relief from depression.


A high level of cortisol is evidence of stress and can cause a lack of sleep in individuals who are experiencing Seroquel withdrawal symptoms. Melatonin helps to regulate the sleep cycle, restore the circadian rhythm in the body, and improve brain function and to reduce anxiety. Serotonin is used to form melatonin; hence if serotonin is low, it directly affects the production of melatonin.

L- tyrosine/ L-Phenylalanine

A deficit of certain neurotransmitters can lead to mental stress. Withdrawal symptoms are caused by the irregularities in the supply of neurotransmitters. L-tyrosine and L-phenylalanine are very effective in the production of dopamine and norepinephrine, which is needed to elevate moods. One should be careful, however, not to take too much of it to avoid complications.
One may go for synthetic vitamins in moderation or go for natural means such as fruits for Vitamin C. some other vitamins can be gotten through organic herbs, foods, and other natural products. While these supplements are very helpful for patients weaning off Seroquel, the results may differ from one individual to the other, as every person is different in sensitivity, susceptibility, and their response to various nature of pharmaceutical products.

Safe Seroquel Home Detox Methods

There is an increasing need to find alternative medications to reduce the withdrawal symptoms of Seroquel. The search has proved abortive as there is still no drug that has been certified to ease Seroquel withdrawal symptoms. The side effects of stopping Seroquel can only be managed by tapering off the medication. The first step is to wean off Seroquel through the help of a doctor, after which a person may switch to a different medication that can ease symptoms without causing dependency.

Some individuals may ask how life after Seroquel is. Is a person likely to go back to the drug after tapering off the drug and living without them for a while? There are a good number of Seroquel withdrawal success stories and experiences with outpatients, which prove that it is possible to overcome the withdrawal symptoms of Seroquel completely. Here are some effective home methods that can be helpful for withdrawal symptoms:

  • Increase the acidity of urine in order to expedite the excretion of drug metabolites from the system
  • As difficult as it may be at that period, exercises are highly effective and can boost metabolism
  • Drink lots of water in order to stay hydrated and to improve the detox process
  • Eat healthy balanced diets
  • Ask a doctor for recommended supplements that can revitalize the system and help with the overall process

If a loved one is struggling with dependency on Seroquel, it is advisable to seek medical attention from an addiction treatment specialist immediately. They will advise the best rehabilitation program and help to find a rehab that will suit one’s needs.

Page Sources

  1. Koch HJ, Severe Quetiapine Withdrawal Syndrome with Nausea and Vomiting in a 65-year-old Patient with Psychotic Depression,
  2. Yargic I, Caferov C., Quetiapine dependence and withdrawal: a case report,
  3. U.S. National Library of Medicine, Quetiapine,

Published on: February 19th, 2020

Updated on: June 12th, 2020


Leave a comment

  • Theresa
    I believe I’m withdrawing off sequel first sweating no fever a weird crawling sensation in my arm can’t sleep went to Dr and rule out everything serious but I believe that’s what’s wrong with me it’s been 1 week I had to stop I got flutter heartbeat don’t like this at all so I decided to stop oh boy it’s horrible how long before it go away it could take 2 wks?
  • Kate
    I have been on Seroquel 300 mg for about 3 months the side effects were so bad that I called the doctor today and he just cut me off cold turkey so doing research this sounds terrible I don’t you know I don’t know what to do he is a doctor he is not my psychiatrist I’m willing to try cold turkey but I hope it works
    • Nicole
      I’ve been on 150mg for only a few weeks, was on 50 mg for a few months prior to that, and it has been a HORRIBLE experience for me! My doc told me to reduce to 100mg for a week, then back to 50mg for a week. I’ve read some horror stories about cold turkey causing insomnia but that’s what the medication is causing me! Along with other issues….
  • Diana Lopez
    My ins. Company will not fill the Seraquel any longer. The Dr. Sent in a PA. The ins. Denied it. We have appealed the denial. Im out of this med. What should I expect for side effects? I’ve been taking Seraquel for many years for bipolar.