Mixing Muscle Relaxers With Pain Killers And Other Substances

Many muscle relaxants on the table

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Want to know whether one can take muscle relaxers and ibuprofen together? These medicines used to treat pain and spasticity. But if someone is mixing muscle relaxers and pain killers or other medication, can it be dangerous for health? In this article, learn more about mixing muscle relaxers and painkillers, interactions with drugs like Valium, Zoloft, and substances like alcohol, cocaine, and marijuana.

It is always better to consult a medical professional before taking any medication with muscle relaxants to avoid complications.
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Table Of Contents:

Mixing Muscle Relaxers And Painkillers

There are numerous factors such as age, body weight, medical conditions, and more that affect the type of medication required by an individual. One should be taking muscle relaxers when experiencing pain or spasms for minor pain relief. But it is not advised to mix painkiller with muscle relaxant as it activates opioid receptors in the gut, brain, spinal cord, and alters the way one perceives pain.

mixing painkillers and muscle relaxers

The painkillers that one should avoid are:

Ibuprofen and Muscle Relaxants Combination

If someone is trying to find out, whether one can take muscle relaxers and ibuprofen together, it is not recommended to mix both of them. If ibuprofen and muscle relaxant are consumed in large doses, it may slow down breathing and leave the person sedated. Other side effects include headache, nausea, tiredness, nervousness, heartburn, constipation, stomach ache, and more.

Mixing Tylenol and Muscle Relaxers

One should not take Tylenol and muscle relaxers as the combination prevents the brain from getting the oxygen it requires.

Combining Tramadol and Muscle Relaxers

Mixing Tramadol and muscle relaxer is not a good idea as both the medicines are known to depress the central nervous system. The interaction also leads to other effects such as coma and respiratory distress. If one experiences any one of the Tramadol and muscle relaxant effects, the patient should seek medical attention immediately.
Do muscle relaxers affect the heart? Vecuronium and rocuronium are the drugs that affect the heart rate of the patient, especially when taken with pain-relieving medication. The risk of overdose is also higher if one is mixing painkillers with a muscle relaxant.

Taking Two Muscle Relaxers

These drugs are not made for long term use and are best used in conjunction with rest and physical therapy. According to the Drug Enforcement Administration, the usual starting dose is 5 mg, three times a day, and the maximum recommended is 10 mg. With this dosage, patients feel better within ten days.
Can one take two muscle relaxers? One must intake pills as prescribed, and should not take two of them together.

Female hand takes a muscle relaxant
According to a publication on Anesthesiology, ASA publications, it was demonstrated that if a shorter-acting pill is taken after a longer-acting one, it takes on the characteristic of the first drug. It also increases their plasma concentration in the patient. The combination also leads to interactions effects such as fatigue, abnormally rapid heart rate, dry mouth, dizziness, drowsiness, and upset stomach.

Although cardiac arrest, deaths, seizure, and chest pain can rarely occur from multiple drug ingestion. Consult an expert doctor on how to get prescribed muscle relaxers before anyone starts or terminate the usage of any medication.

Mixing Muscle Relaxers And Benzodiazepines

In rare cases, benzodiazepines are used to relieve spasticity and pain due to various neurological disorders such as spinal cord injury and strokes. But if someone mixes them, the individual becomes prone to face many interactions.

Valium And Muscle Relaxers Combination

There is a moderate interaction between Valium and muscle relaxants. The combination of Valium and muscle relaxant leads to an increase in various adverse effects such as confusion, dizziness, and drowsiness. Elderly individuals may experience impairment in thinking, motor coordination, and judgment.

Xanax And Muscle Relaxants Combination

The combination of Xanax and muscle relaxant leads to numerous side effects, including confusion, drowsiness, dizziness, and difficulty in concentrating.

Combining Muscle Relaxers With Other Drugs

While these drugs have harmful interactions with painkillers and the drug of the same class, here are how they interact with other drugs:

Zoloft And Muscle Relaxers

Zoloft interactions with muscle relaxers increase the risk of quite a health condition known as Serotonin Syndrome. The symptoms of this syndrome include seizures, hallucinations, increased heart rate, fever, spasms, nausea, cramps, in-coordination, and diarrhea.

Hand hold many muscle relaxers

Cymbalta And Muscle Relaxers

The drug interactions with Cymbalta and muscle relaxers may also lead to Serotonin Syndrome. One should seek immediate help if these symptoms come up.

Novocaine And Muscle Relaxers Interaction

The drug interactions between novocaine and muscle relaxers only show the effect at the neuromuscular junction. According to a study on the US National Library of Medicine National Institutes of Health, an individual who is receiving high enough dose of both agents can suffer from NM block.

Mixing Aleve and Muscle Relaxers

Can you take Aleve with muscle relaxers? One can go for this combination as Aleve does not have any interactions with them. According to a study published in the US National Library of Medicine National Institutes of Health, the combination therapy consisting of naproxen and muscle relaxant benefits patients with acute low strain than this drug alone.
Although OTC painkillers are recommended as first-line therapy for spasms, one can take OTC NSAIDs rather than over the counter muscle relaxant, which are topical solutions mostly. If someone has combined muscle relaxers for TMJ with other drugs, it is better to seek help.

Muscle Relaxers And Substances Interactions

These drugs are known to enhance the effects of central nervous system depressants such as alcohol and or cannabis. Individuals who combine these drugs with the following substances do it to experience enhanced euphoria, relaxation, and psychoactive effects. However, there are some interactions associated with these combinations that one should be aware of.

Taking Muscle Relaxers And Alcohol Together

Alcohol is known to produce some pain-relieving effects, but taking these drugs at the same time as drinking alcohol is not advised. Both of them depress the central nervous system in the same ways.


Some of the muscle relaxers and alcohol side effects also include fatigue, drowsiness, dry mouth, nausea, and confusion. Severe effects include the risk of overdose and co-occurring addiction. If one has overdosed on the combination, go for immediate medical detox is required.

Cocaine And Muscle Relaxers Together

Mixing cocaine and muscle relaxants come with dangerous interactions and side effects. The results include an increase in side effects of both substances, risk of development of addiction or polysubstance dependence.

Mixing Weed And Muscle Relaxers

Using them together with cannabis, increases side effects such as drowsiness, confusion, dizziness, and difficulty in concentrating. Due to harmful interactions of CBD and muscle relaxant, an individual can experience impairment in thinking and judgment.

Marijuana joint mixed with muscle relaxers
Wondering whether one can get high off muscle relaxers? One can get high off them, but this experience can result in numerous side effects or overdose.

Valerian And Muscle Relaxers Interaction

One should also avoid valerian and muscle relaxant combination as it makes the patient sleepy and can lead to increased tiredness and drowsiness. Valerian can be used as an effective herbal muscle relaxer, but not in combination with other pills.

Drug Interactions Treatment

Whether an individual is suffering from lower back pain or spasticity, it is essential to get them treated. They are quite likely to be treated with physical therapy, relaxants, and rest, but it is important to set an appointment with a doctor for the best results. Prescription muscle relaxers are not entirely safe and can cause addiction. Professional addiction treatment should be sought if drug abuse took place. In any case, drug misuse and co-occurring addictions are advised to treat in substance abuse rehabs.

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View Sources
  1. Borenstein DG, Lacks S, Wiesel SW. Cyclobenzaprine and naproxen versus naproxen alone in the treatment of acute low back pain and muscle spasm, https://www.ncbi.nlm.nih.gov/pubmed/2141299
  2. Matsuo S, Rao DB, Chaudry I, Foldes FF, Interaction of muscle relaxants and local anesthetics at the neuromuscular junction, https://www.ncbi.nlm.nih.gov/pubmed/568429
  3. A. W. Harrop-Griffiths, J. R. Hood, Interaction between Nondepolarizing Muscle Relaxants, https://anesthesiology.pubs.asahq.org/article.aspx?articleid=2028679
  4. Drug Enforcement Administration, CYCLOBENZAPRINE, https://www.deadiversion.usdoj.gov/drug_chem_info/cyclobenzaprine.pdf

More About Muscle Relaxants:

Olivier George

About Author

Olivier George, Ph.D.

Olivier George is a medical writer and head manager of the rehab center in California. He spends a lot of time in collecting and analyzing the traditional approaches for substance abuse treatment and assessing their efficiency.

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