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Naproxen Drug Interaction – Is It Safe To Combine Aleve And Tylenol?

Mixed Pills On White Table

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The concomitant use of Aleve with other drugs can result in a variety of Naproxen interactions. It is important that patients are aware of the various Naproxen drug interactions with common drugs such as Xanax, Tylenol, Acetaminophen, etc. This article serves as an informational guide about different Naproxen drug interactions and the side effects Naproxen induces during the interaction.

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Table of Content

Mixing Naprosyn And Alcohol

Naproxen sodium is a nonsteroidal anti-inflammatory drug (NSAID) used as a pain reliever during muscle and joint aches. Taking Aleve with alcohol is generally unsafe and leads to a dangerous interaction. On a closer look, Naproxen works by reducing the presence of prostaglandins (protects the stomach lining) in the body. With a low presence of prostaglandins due to the use of Naprosyn, it takes only a few shots of alcohol for the stomach lining to become more vulnerable to gastritis.

Combinating the medicine with alcohol can pose a great risk of death from gastrointestinal bleeding

Patients who simultaneously abuse alcohol and this medicine to experience Naproxen 500 high are susceptible to such side effects as:

  • Holes in the stomach or intestine
  • Ulcer
  • Coughing up blood
  • Black and sticky stool
  • Low red blood cell count, which can cause fatigue, lethargy, and weakness

Mixing Aleve And Ibuprofen

Ibuprofen, mostly referred to as Advil, is an NSAID, just like Naproxen. Naproxen and Ibuprofen both work in the same way―by reducing the presence of prostaglandins in the body. However, their duration of action differs.

Two Different Pills In A Hand

Consuming Naproxen and Ibuprofen together is very harmful, and can lead to severe side effects. Since both drugs basically do the same thing in the body, patients expose themselves to severe NSAID side effects if used together.

Some of these side effects include:

  • GI bleeding
  • Stomach upset
  • Cardiomyopathy
  • Kidney Failure
  • Hemophilia

Mixing Naprosyn And Tylenol

Depending on the degree of pain, and purpose of use, it is considered safe to combine Naproxen and Tylenol. However, patients must ensure not to abuse this combination.
Due to their differences in dosing routine, both drugs can only be consumed twice in 24 hours. Naproxen and Tylenol are two different classes of drugs, which means their mechanism of action differs.

Taking low doses of Naproxen with Tylenol will provide significant pain relief.

Patients may experience any of these symptoms as a result of interaction:

  • Difficulty breathing or swallowing
  • Swelling of face, lips, throat, or tongue
  • Hives
  • Severe itching
  • Peeling or blistering skin

Mixing Naprosyn And Acetaminophen

While both Naproxen and Acetaminophen are used to relieve pain, they work in different ways and have overlapping side effects. However, for most people, the concomitant use of these medicines is generally safe for use and patients are less likely to experience any interaction. In fact, alternating the intake of both drugs together can help reduce pain faster, however, patients should not take Naproxen or Acetaminophen for 10 days in a row.

Mix Of Pills In Female Hands

Also, overdosing on both drugs can lead to some side effects which include

  • Nausea
  • Stomach pain
  • Loss of appetite
  • Itching
  • Rash
  • Headache
  • Dark urine
  • Bleeding in the stomach
  • Liver damage

Mixing Aleve And Gabapentin

The concomitant use of Naproxen and Gabapentin can lead to some serious interaction. According to a report, combining both drugs can increase the amount of gabapentin absorbed in the body. Although an increase in Gabapentin in the body is less likely to cause adverse effects, however, extra caution is advised when using this combo to prevent overdose.

Each combination of medicine requires medical supervision. Only a medical professional has the right to assign drug combinations, review them, and cancel. In case one is experiencing adverse reactions due to the combination of meds – contact medical specialists immediately

Listed below are some side effects that can be experienced when combining Naproxen 500mg tablets or more with Gabapentin:

  • Headaches
  • Migraines
  • Dizziness
  • Difficulty speaking
  • Lack of coordination
  • Amnesia

Mixing Aleve And Xanax

Based on current data and research, there is really no known interaction that would make the use of Naproxen and Xanax dangerous to one’s health. Notwithstanding, patients may experience side effects such as

  • Constipation
  • Drowsiness
  • Fatigue
  • Memory impairment
  • Anxiety
  • Blurred vision

Mixing Naprosyn And Hydrocodone

Naproxen and Hydrocodone are considered safe to use together based on current research and data available. However, this doesn’t mean patients won’t experience some minor to major side effects. On a general note, it is advisable for patients to use low doses of Naproxen with Hydrocodone to prevent overdose.

Preventing The Disastrous Interaction

Naproxen over the counter is a pain reliever with low chances of abuse, making it an efficient option for pain treatment. However, to avoid Aleve interactions, it is crucial for people to always follow the doctor’s prescription.
Do Naproxen and breastfeeding go together? No. Pregnant women should avoid using Aleve because it stays in the body for a long time and can result in bleeding and anemia for infants.
For someone already addicted to medicine, enrolling in medical treatment for addicts in a rehab facility is the best solution. Rehabilitation centers provide healthcare services like counseling and treatment to prevent relapse and dependence.

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  1. FDA Neurontin Prescribing Information
  2. FDA Naproxen Prescribing Information,18164s60,18965s18,20067s17lbl.pdf


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