Amitriptyline Side Effects: Common And Rare Risks

Last Updated: February 7, 2020

Authored by Sharon Levy, MD, MPH

Elavil, a tricyclic antidepressant, also known by its generic name amitriptyline, produces side effects in patients similar to other medications of its drug class. There are amitriptyline side effects that are more common than others since they are manifested in many of the patients. The side effects of amitriptyline may also vary in intensity, with some patients reporting mild symptoms, while others experience more adverse side effects. Of importance, however, is that patients who experience side effects of Elavil should seek professional medical assistance to help manage them.

What Are The Most Common Side Effects Of Amitriptyline?

These reactions are those which are most commonly experienced by patients. These usual amitriptyline reactions are usually far less acute and tend to disappear with continual usage of the drug. However, if these symptoms do not disappear, users are advised to consult a doctor. The common side effects of amitriptyline HCl may include the following:

  • dry mouth
  • drowsiness
  • dizziness
  • headache
  • gastrointestinal upset
  • constipation
  • weight gain
  • nausea or vomiting
  • excessive sweating

Elavil causes dry mouth

Does Amitriptyline Cause Dry Mouth?

Yes, Elavil does cause the development of a dry mouth. This side effect is common for many patients who take a dose as little as 40 mg before bedtime. To prevent the dry mouth side effects of Elavil, patients are advised to discuss the schedule of drug intake with their doctor.

Does Amitriptyline Make One Sleepy?

Indeed, Elavil causes languor or sleepiness. This is one of the amitriptyline common side effects which can be ascribed to the medication’s response to histamine levels in the cerebrum. Besides, patients will, in general, report drowsiness when they get a dosage increment. It is prudent not to drive or operate heavy equipment during this period, and Elavil dosage increase should be done, at least, in 7 days.

how Elavil affects sleep

Rare Side Effects Of Elavil

These are amitriptyline adverse effects that are less commonly experienced by patients and may include:

  • difficult or painful urination
  • abnormal heart rhythm
  • decreased sex drive
  • blurred vision
  • low blood pressure
  • nervousness
  • muscle tremors
  • suicidal thoughts
  • hallucination
  • difficulties with attention
  • acute glaucoma
  • yellowing of the skin or the white part of the eyes
  • cloudy thinking

Does Amitriptyline Cause Hair Loss?

Yes, hair loss is one of the rare but long term effects of amitriptyline use. However, this side effect is usually reversible; patients should talk to a doctor if they experience it. Tricyclic antidepressants (TCA is Elavil classification) and SSRIs are known to cause hair loss, although not that common. Elavil’s weight gain is another long term side effect of the two drug classes.

dangers of Elavil for people with heart problems

Can Amitriptyline Cause Heart Problems?

Irregular heartbeat is one of the uncommon side effects of Elavil. It raises the pulse by influencing the electrical signals in the heart, making it beat quicker. Amitriptyline drug interactions for those patients who take MAOIs such as isocarboxazid, linezolid, methylene blue infusion, phenelzine, rasagiline, selegiline, or tranylcypromine can likewise cause incredible hypertension.

Amitriptyline Sexual Side Effects

Elavil does not directly affect fertility, but patients should consult a doctor when they are trying to conceive while on it. Nonetheless, there have been cases of erectile or ejaculatory dysfunction in males and vaginal bleeding in females. This prescription influences arousal and sex drive more than sexual climax and ejaculation in male patients, but it affects only libido in female patients. However, these are not long term effects of amitriptyline on sexual life, as they usually disappear after the first few weeks of taking the drug. If these adverse reactions persist, patients are advised to seek medical assistance.

Elavil during breastfeeding

Elavil Side Effects During Pregnancy & Breastfeeding

There isn’t much research on amitriptyline adverse effects during pregnancy and breastfeeding. Hence, the drug should only be used by pregnant women when the benefits are more than the associated risks.

Although the amount of Elavil that can be excreted from breast milk is small, a doctor should be informed if a mother plans to breastfeed or is already breastfeeding. Research of the side effects of Elavil on breastfeeding newborn children by the National Center for Biotechnology Information has discovered that a nursing mother endorsed amitriptyline 10 mg day by day for a sleeping disorder had her 15-day-old baby developed extreme sedation and diminished breastfeeding. This does not mean that each case will include the same congenital abnormality.

Know Elavil Side Effects For Their Timely Management

Amitriptyline side effects may either be acute or mild. Regardless of a condition, Elavil is prescribed to, either it is amitriptyline for migraines or MDD, some common reactions may manifest. These side effects of amitriptyline usually disappear over time when the body starts successfully tolerating the drug. The side effects of Elavil may be a result of the abuse of the medication. In this case, it is critical to consult health professionals as soon as possible to get a proper treatment plan. Such facilities as drug abuse centers are among the best to provide the right treatment.


Page Sources

  1. Amitriptyline - for depression. NHS. 2018. https://www.nhs.uk/medicines/amitriptyline-for-depression/.
  2. National Center for Biotechnology Information. PubChem Database. Amitriptyline, CID=2160, https://pubchem.ncbi.nlm.nih.gov/compound/Amitriptyline.
  3. Gupta B, Shakarwal MK, Kumar A, Jaju BP. Effect of amitriptyline on blood glucose level in rabbits. Indian Journal of Physiology and Pharmacology. 1995; 39(3): 279–282. https://pubmed.ncbi.nlm.nih.gov/8550126-effect-of-amitriptyline-on-blood-glucose-level-in-rabbits/.

Published on: February 7th, 2020

Updated on: February 7th, 2020

About Author

Sharon Levy, MD, MPH

After successful graduation from Boston University, MA, Sharon gained a Master’s degree in Public Health. Since then, Sharon devoted herself entirely to the medical niche. Sharon Levy is also a certified addiction recovery coach.

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