Lisinopril Half-Life: How Long Does Lisinopril Stay In System?

Last Updated: June 4, 2020

Blood pressure medication is vital for people with hypertension. Lisinopril – blood pressure medicine is commonly prescribed. Patients should know all the information about the drug before they take it. This includes an overview of Lisinopril’s half-life, metabolism, exertion, and ability to cause false positives on drug tests. Understanding how long the medicine remains in the system ensures the person knows what to expect. It also provides a better understanding of how to time doses appropriately. This post aims to provide a clearer answer to the question of how long does Lisinopril lasts.

Lisinopril Half-Life

Lisinopril (Prinivil, Zestril) is generally used as an ACE inhibitor to help reduce blood pressure in patients with hypertension. Patients are advised to be aware of all factors related to the drug before they use it. This gives the person a better understanding of what they should expect. Asking about the half-life of Lisinopril is one particularly significant factor that needs to be covered. This refers to the time it takes for half of the chemicals in the medicine to be expelled from the individual’s body.
When asking how long it takes for Lisinopril to leave the body, about half of the drug’s concentration will be out of the body within 12 hours after administration. To be more specific, the half-life of medicine is stated as 12.6 hours. This conclusion was made by a research study published in the American Journal of Medicine. At this time, half of the dosage will be out of the person’s body.
researchers working in life science laboratory.

Lisinopril Metabolism And Excretion

The metabolism of the medicine comes into play when asking how long it takes for Lisinopril to start working. The metabolism of a drug also affects the time it will remain active in the system. Such data can also help a person better understand the possible Lisinopril adverse effects.
An important factor to consider about this medicine is that the drug is not broken down by the person’s liver. Most drugs that are administered will be broken down by the patient’s liver. This is not the case with Prinivil.

Factors Affecting Zestril Detection Window

When looking at how long Lisinopril stays in the system, a person should note that there are a few factors that affect this calculation. First of all, this drug is known to have poor bioavailability. Prinivil classification is an ACE inhibitor. The drug is not metabolized by the liver, like many other medicines used to treat hypertension.

There are other factors that need to be taken into consideration too. This include:

  • Organ damage can increase the time it takes for the drug to leave the body. Kidney damage is the factor to be taken into concern here.
  • Some other substances can also increase the time it takes for the drug to be metabolized. While Lisinopril and potassium may not have such an interaction, using the drug with alcohol may cause a delay in metabolism.

How Long Does It Take For Lisinopril To Get Out Of The System?

Apart from asking how Lisinopril is metabolized when looking at the detection window, it is also important to understand that the chemical’s detection rate depends on the compound in the human body being tested. The time it takes for the chemical to leave the body differs between urine, hair, blood, and saliva samples.
Smiling doctor sitting at the table.

How Long Does Lisinopril Stay In Urine?

When looking at what the half-life of Lisinopril is, many people start by considering the time it takes the drug’s chemicals to be undetectable in the urine. In most cases, the drug remains detectable in urine for up to four days after the administration of the medicine.

How Long Does Lisinopril Stay In Hair?

The drug remains active in hair follicles for a longer time compared to other samples that may be used for testing. It is possible that the chemical found in the drug can be detected up to 90 days after the administration of the drug. There are also cases where the drug remains detectable for longer than 90 days.

How Long Does Lisinopril Stay In Blood?

Lisinopril leaves the blood circulatory system rather quickly. In most people, the drug will not be detectable in a blood sample after 24 hours have passed since the last use of the medicine.

How Long Does Lisinopril Stay In Saliva?

The detection window for saliva is very similar to blood. The chemical will remain detectable in a patient’s saliva for an estimated 24 hours period after the last dose was taken.
Young girl at doctors appointment.

How To Detox From Prinivil Faster?

Medical detox is the initial step in addiction treatment. After completing this phase, a suitable inpatient or outpatient drug rehab program should be chosen for a successful recovery.
People need to understand what Lisinopril is for. This helps them ensure they only use the medicine appropriately. Some individuals have been found to abuse the medication. In such a case, it is important to stop Lisinopril before serious complications are experienced. A drug detoxification process can be used to get the chemicals out of the system faster. This can also help to reduce the risk of severe withdrawal effects.

Page Sources

  1. Beermann B, Pharmacokinetics of lisinopril,
  2. Edgardo Olvera Lopez, Mayur Parmar, Venkata Satish Pendela, Jamie M. Terrell, Lisinopril, 2020,

Published on: March 11th, 2020

Updated on: June 4th, 2020


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