Lisinopril Alternatives: Are There Any Better Alternatives To Lisinopril?

Last Updated: March 11, 2020

Lisinopril, also known as Zestril or Prinivil, is often recommended for hypertension, may often present with minor to significant side effects such as weight gain, hyperkalemia, increased serum creatinine, and others. Consequently, some individuals may want to explore other Lisinopril alternatives even though the medication is essential as a cardiovascular risk reduction regimen. The medication is often combined with a diuretic depending on the health condition. Some side effects experienced with Zestril may be peculiar to the drug alone and varies from one person to another, causing the need for alternatives.
The best substitute for medication Lisinopril would be one that has lesser adverse effects and is just as effective. Individuals who have experienced drug interactions after taking it often ask, what should one take instead of Lisinopril? Here are a few alternatives to Lisinopril.

Prinivil, Zestril Alternatives Among (ACE) Inhibitors

Prinivil belongs to a class of drugs known as ACE inhibitors. There are other medications in the same class that have similar functions with Zestril and can serve as an alternative to Lisinopril. ACE inhibitors are best used in individuals suffering from heart failure and or diabetes. The following medications belong to the class of Angiotensin-converting enzyme (ACE) inhibitors.

Lisinopril alternatives pills and herbal capsules.

Enalapril vs. Lisinopril

A comparative study on Enalapril vs. Lisinopril for efficacy showed that Zestril recorded a more significant result in 24 hours. It is also considered a more effective antihypertensive therapy and slightly superior due to its longer pharmacokinetic difference, persistence, and half-life.

Benazepril vs. Lisinopril

The Benazepril vs. Lisinopril comparison is seen to have near-to-equal efficiency in treating hypertension as well as decreasing the risks of a heart attack. In addition, it is used as a regimen for the prevention and treatment of vision loss due to diabetes.

Ramipril vs. Lisinopril

Is Ramipril a better tolerated Lisinopril substitute? According to findings, Ramipril is one of the most preferred angiotensin-converting enzyme (ACE) inhibitors with a high rate of improving cardiovascular health. Ramipril vs. Lisinopril comparison shows a more consistent patient response for Ramipril with minimum side effects. As for the propensity to treat chronic heart failure, both medications are equally effective. Ramipril has a half-life of 50 hours, while Prinivil has 16.4 hours.

Captopril to Lisinopril

Prinivil is reported to be more effective for congestive heart failure and as antihypertensive medication than Captopril. Individuals that seek a Captopril to Lisinopril conversion may follow a dosage ratio of 5:1 for mild or moderate hypertension. Captopril has a halflife of 2.1 hours, while Zestril has an average of 16.4 hours.

Zestril vs. Angiotensin II Receptor Blockers

The following medications are effective for hypertension; however, they may function differently from ACE inhibitors as they are of different classes. Drugs that belong to this group are best used in cases of diabetes or heart failure.

Lisinopril vs. Losartan

Lisinopril vs. Losartan comparisons show that the angiotensin II receptor antagonist, Losartan, is less likely to cause cough, unlike Prinivil. However, both medications function on the renin-angiotensin system to decrease blood pressure.
The Losartan dosage compared to Lisinopril is slightly higher at 25-100mg daily, while Prinivil is 5-40mg daily. The Lisinopril to Losartan conversion is likely to have similar reactions as well as side effects.

Healthy dietary supplementation.
Which is stronger Losartan or Lisinopril? Both medications have been reported to be equally effective. However, they should never be taken together. Those who desire a change in medication should endeavor to consult a medical doctor for proper assessment.

Valsartan vs. Lisinopril

The essence of drug comparisons is largely to understand the mechanism of action of each medication and how they affect patients in contrast. Lisinopril-valsartan antihypertensive therapy is used to control blood pressure in patients. The argument is which medication is most effective? Lisinopril vs. Valsartan assessment showed that both medications proved effective for managing mild to severe high blood pressure in patients; however, the adverse effect risks were greatly reduced for Valsartan.

Alternatives Among Calcium Channel Blockers

These groups of medications are mostly administered to people with cases of Angina (chest pain), and irregular heartbeat.

Lisinopril vs. Amlodipine

There have been reports on Lisinopril and Amlodipine comparisons, and most results show Amlodipine to be more effective. Amlodipine vs. Lisinopril comparisons revealed a significant reduction in diastolic and systolic units that were more prominent in Amlodipine. This result is more frequent in black patients and women.
Lisinopril alternatives.

Prinivil vs. Beta-Blockers

Drugs in this group help to reduce heart rate, heart palpitations, chest pain, as well as irregular heartbeat.

Atenolol vs. Lisinopril

Lisinopril drug interactions and adverse effects are often the basis for patients seeking alternatives to the medication. Atenolol is a beta-blocker that aids the heart’s blood pressure circulation. Atenolol vs. Prinivil distinction is largely in their mode of action. According to reports, Prinivil produces a greater reduction in systolic pressure than Atenolol.

Metoprolol vs. Lisinopril

Many hypertension medications work to improve arterial distensibility as well as reduce blood pressure in hypertensive patients. A Metoprolol vs. Lisinopril contrast assessment showed that Zestril functioned better in the improvement of arterial distensibility (vessel wall expansion).

Natural Alternatives to Lisinopril

Medications are usually the best for controlling blood pressure; however, some of these medications may present with unfavorable side effects that can impair physical health. There are natural alternatives to Lisinopril and other hypertension medications. These natural methods are quite effective and can help one wean off the medication Zestril and others.
Food contains coenzyme Q10.
Supplements are natural alternatives for Prinivil. However, not all supplements are interchangeable with hypertension medications. It is best to discuss these conditions with a medical doctor for the best advice on what supplements to take. In order to stop taking Lisinopril, one must wean off the medication rather than stop abruptly. From a max dose of Lisinopril, one can reduce doses of the medication and augment with supplements or increase potassium levels by taking bananas or tomato juice.
Taking coenzymes and antioxidants are also very helpful in reducing one’s blood pressure significantly. Whatever natural method one chooses, it is best to discuss it with a medical doctor for best practices before taking action.

Switching From Prinivil Safely

It is not advised to stop taking Zestril abruptly. It might be dangerous to suddenly stop taking the medication without first consulting a doctor. The individual stands a high risk of rebound hypertension. The condition known as rebound hypertension is a spontaneous rise in blood pressure, which occurs when a highly potent hypertensive medication is stopped. To stop the medication, one should contact a doctor for instructions on how to wean it off.
Also, it can be quite difficult for some patients to wean off Zestril because of substance abuse disorder. If any signs of abuse are noticed in patients, they should schedule an appointment with a healthcare specialist in the addiction treatment field. They can correctly diagnose abuse issues that occurred and find the right substance rehab facility to recover.

Page Sources

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  3. Ramsay LE, Yeo WW, Losartan Cough Study Group, Double-blind comparison of losartan, lisinopril and hydrochlorothiazide in hypertensive patients with a previous angiotensin converting enzyme inhibitor-associated cough,
  4. Malacco E, Santonastaso M, Varì NA, Gargiulo A, Spagnuolo V, Bertocchi F, Palatini P, Comparison of valsartan 160 mg with lisinopril 20 mg, given as monotherapy or in combination with a diuretic, for the treatment of hypertension: the Blood Pressure Reduction and Tolerability of Valsartan in Comparison with Lisinopril (PREVAIL) study,
  5. Lorimer AR, Lyons D, Fowler G, Petrie JC, Rothman MT, Differences between amlodipine and lisinopril in control of clinic and twenty-four hour ambulatory blood pressures,
  6. Pannier BE, Garabedian VG, Madonna O, Fouchard M, Darne B, Safar ME, Lisinopril versus atenolol: decrease in systolic versus diastolic blood pressure with converting enzyme inhibition,

Published on: March 11th, 2020

Updated on: March 11th, 2020


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