Lisinopril Interactions: Dangers Of Mixing Zestril And Other Substances

Last Updated: June 3, 2020

Prinivil is a medication often administered for the treatment of congestive heart failure, high blood pressure, diabetic kidney disease, and other heart-related conditions. Lisinopril interactions, however, have been repetitive, making it difficult to fully determine the outcome of taking the drug alongside other medications. Lisinopril drug interactions occur for various reasons. In some cases, it may be a food and drug reaction, and in other occurrences, side effects may be from concomitant use with other substances and medications.
For this reason, it is imperative to understand what not to eat while taking lisinopril.  Some interactions improve the effectiveness of the medication, such as lisinopril and hydrochlorothiazide, also called Lisoretic in combination. While others, such as Lisinopril-Viagra, may cause unpredictable results.
People often ask, what pain relievers can one take with Lisinopril? For others, what foods should be avoided when taking Lisinopril? Let’s take a closer look at the interactions of this medication.

Lisinopril And Alcohol

In order to understand the dangers of certain substance mixtures with the medication, one has to first fully comprehend the mechanism of the drug. How does Lisinopril work?  It is an Angiotensin-converting enzyme inhibitor (ACE inhibitor) that functions by blocking the ACE enzyme, creating a wider blood vessel passage for blood flow, improving circulation, and heart rhythm. So how does Lisinopril and alcohol mixture become a problem?

woman taking lisinopril drug with alcohol.
Firstly, a Lisinopril-alcohol combination can impede the effectiveness of the drug as drinking alcohol increases blood pressure, which works in reverse as the medication. An inverse possibility is a drop in blood pressure that leads to dizziness or a sudden increase in blood pressure to its extremities leading to heart failure. Typically, a mixture of alcohol and Lisinopril present with side effects, and the effects of either Prinivil or alcohol may be amplified, leading to health complications.

Lisinopril Drug Interactions

There is a long list of drugs that should not be used together with Zestril. Many Lisinopril warnings are specific for pain relievers, ACE inhibitors, medications that alter renal functions, and others. Here are some concomitant uses that should be avoided:

Mixing Lisinopril And Ibuprofen

Can one take Ibuprofen and lisinopril? Antihypertensives such as Zestril and Non-steroidal anti-inflammatory drugs (NSAIDs) such as Ibuprofen have been continually tested for more comprehensive detail on the clinical effects of concomitant use. It has been discovered in most cases that Ibuprofen increased the blood pressure significantly. Lisinopril and Ibuprofen can be said to have countering effects in functionality. Ibuprofen and Lisinopril combinations may alter the ability of Zestril to lower blood pressure.

Metoprolol And Lisinopril Interactions

Lisinopril and Metoprolol are both antihypertensives that can be used alternatively in the treatment of moderate or mild hypertension.  In certain conditions, patients may combine ACE inhibitors and beta-blockers such as metoprolol to achieve effectiveness. Both medications are safe for use. However, it should be recommended by a doctor for safety.

Lisinopril And Amlodipine

Some people may experience Amlodipine besylate and Lisinopril side effects such as dizziness, nausea, palpitations, stomach pain, and others. When these side effects present themselves, one should consult a doctor immediately for a Lisinopril alternative.

Prinivil And Tylenol

Some Pain relievers are unsafe to take with heart medications. People often ask, can one take Tylenol with Lisinopril? So far, no interactions have been recorded with Lisinopril and Tylenol.
lisinopril drug interactions concept.

Zestril And Viagra Combination

On many occasions, erectile dysfunction medications and blood pressure drugs have been used together with no side effects. Lisinopril and Viagra are relatively safe. However, Nitrates should be avoided while using these medications as it could lead to a drastic drop in blood pressure of the patient. In some cases, Viagra and Lisinopril may work together to achieve the same objective as well as boost an individual’s sex life.

Benadryl And Lisinopril

Benadryl may cause a drop in blood pressure which may lead to side effects such as dizziness, palpitations, lightheadedness, and other conditions. It is unadvised to take Benadryl and LIsinopril concurrently without the counsel of a medical doctor.

Zestril And Aspirin

Lisinopril and aspirin may be used together in low doses, such as 75mg per day for aspirin. However, Aspirin and Lisinopril, if misused, may present with side effects. Hypertensive patients or those with kidney issues should consult a doctor for confirmation of doses where applicable.

Prinivil And Metformin

However, according to research, Metformin has no effect on blood pressure.

Melatonin And Zestril

Those who use blood pressure medications are usually advised to take melatonin in moderation. Melatonin and Prinivil mixtures may have adverse effects on the blood pressure of the patient. It is imperative to consult a doctor before taking both substances to avoid complications.

 woman taking medicine

Cialis And Lisinopril Interactions

Zyrtec And Prinivil

Allergy medications and decongestants are known to increase heart rhythms. However, Zyrtec and Lisinopril have been found to have no side effects or negative interactions. Always discuss the use of both medications with a doctor before usage.

Atenolol And Lisinopril

Researchers have found no interactions between Atenolol and Lisinopril when used together. However, this does not imply that there are no possible exceptions. Both medications are often used as treatment regimens for hypertensive patients.

Zestril And Aleve

The combination of Lisinopril and Aleve may be dangerous for individuals with cases of high blood pressure. Non-steroidal anti-inflammatory drugs (NSAID) such as Aleve (Naprosyn) may cause blood pressures to rise significantly, putting pressure on the heart and kidney. When combined with Zestril, the results may be unpredictable.

Prednisone And Lisinopril Interactions

There are possible interactions when Prednisone and Lisinopril are used concurrently. Prednisone may alter the effectiveness of Prinivil as a blood pressure regulating medication. It is advised to see a doctor first for advice on how and if to use both medications at the same time.

Bactrim And Zestril

Care should be taken not to use Bactrim and Lisinopril together as Bactrim has been found to increase the blood potassium levels significantly. High levels of potassium in the blood can be fatal, causing health problems such as cardiac arrests, palpitations, kidney failure, and others. Bactrim is a combination of antibiotics and has the tendency to cause Hyperkalemia when taken with Zestril.

man compare lisiniopril to xanax.

Xanax And Lisinopril

Individuals who take medications for anxiety, as well as blood pressure medications, should be extremely careful. Xanax and Lisinopril should not be used concomitantly as they may have additive effects. Some side effects of the combination may include palpitations, dizziness, headache, lightheadedness, etc.

What Foods Should Be Avoided When Taking Lisinopril?

Some minerals contained in food types may have a possible negative effect on the body when using blood pressure medication Lisinopril. Here are some foods to avoid while taking Lisinopril.

Prinivil and Potassium

Zestril is an angiotensin-converting enzyme (ACE) inhibitor, which may increase potassium levels in the blood in addition to treating high blood pressure. Lisinopril and Potassium would lead to high levels of potassium in the blood.  It is often advised to reduce the intake of foods that may cause the addition of potassium in the body while taking Zestril as Lisinopril-Potassium mixture can cause Hypokalemia.

Lisinopril And Grapefruit

Can one eat grapefruit while taking Lisinopril? No. The FDA has issued reports and warning on the eating or drinking of grapefruit while on Zestril medication. A major characteristic of grapefruit is that it increases the levels of a particular medication in one’s blood; this can increase its side effects. The juice of grapefruit interacts with hypertension medications to increase the drug concentration in the blood. In the case of Lisinopril and grapefruit juice, the levels of budesonide will increase significantly, leading to many side effects. It is imperative to talk to a doctor about the possible effects of grapefruit and Lisinopril before use.

grapefruit filled with Lisinopril pills.

Prinivil And Caffeine Interactions

There have been controversies on the effects of coffee on blood pressure medications. It was found that coffee impeded the efficiency of blood pressure medications. Lisinopril and coffee interactions may lead to increased blood pressure.
However, there is also the issue of caffeine and decaffeinated coffee, as the decaffeinated coffee was found to have a less altering effect on the effectiveness of hypertension drugs as opposed to Lisinopril and caffeine. This does not completely discard the reverse effect that coffee may have on the medication.

Zestril And Bananas

Due to health reasons, many individuals often ask, can one eat bananas while taking Lisinopril? Bananas are rich sources of potassium, which are considered very healthy for the body.

Prinivil And Magnesium

Many medications and supplements that contain magnesium have been found to have no visible interaction with Zestril.
Lisinopril and magnesium may have no side effects. However, there is a need to consult a doctor for counseling before use.

Turmeric And Lisinopril

Turmeric supplements are often taken for health and vitality. Certain doses of Turmeric can reduce blood pressure as well as sugar levels in the blood. Turmeric and Prinivil usage should be done with caution to avoid escalating the effects of the medication.

What Can Be Done To Avoid Dangerous Interactions?

Many medications often come with counter-interactions and other forms of side effects when used concurrently with other medications. Some medications may have an adverse effect when used with mineral supplements, not to mention those minerals contained in daily foods.

Notice, that consumption of ACE inhibitors with alcohol or in large quantities may be a sign of abuse. If such behavior patterns were noticed in a patient, an addiction treatment specialist should be consulted. If substance abuse disorder is indeed present in a patient, then a suitable drug rehab facility will be advised.

Page Sources

  1. van Dusseldorp M, Smits P, Thien T, Katan MB,Effect of decaffeinated versus regular coffee on blood pressure. A 12-week, double-blind trial,
  2. Jawad Kiani, Sardar Z Imam, Medicinal importance of grapefruit juice and its interaction with various drugs,
  3. Pavlicević I, Kuzmanić M, Rumboldt M, Rumboldt Z, Interaction between antihypertensives and NSAIDs in primary care: a controlled trial,

Published on: March 11th, 2020

Updated on: June 3rd, 2020


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