Viibryd Side Effects: How Long Do They Last?

Last Updated: February 25, 2020

Authored by Roger Weiss, MD

Vilazodone is a powerful prescription medication that helps people overcome major depressive disorder. While it is generally suitable for most patients, Viibryd side effects can present a significant obstacle to others. To benefit from treatment, patients should know what negative impacts this medication can have and how to cope with them. It’s also crucial to learn when vilazodone side effects may require medical intervention.

What Are The Most Common Side Effects Of Viibryd?

Statistically, approximately 7.1% of patients discontinue Viibryd therapy due to various side effects. The most common vilazodone side effects include diarrhea, nausea, vomiting, and sleep problems. The National Center for Biotechnology Information (NCBI) reports that nearly 28% of patients on this drug suffer from diarrhea, and 5% experience vomiting.

In some cases, patients might experience itching and rashes. If they don’t go away quickly, these Viibryd side effects might indicate that the person is allergic to the medication and needs to find an alternative. Allergies can be potentially life-threatening, and it’s important to watch out for the signs of them.

Other common adverse effects of the drug include:

  • tiredness
  • headache
  • restless legs
  • minor dizziness
  • sweating
  • tinnitus

Rare Side Effects Of Vilazodone

Some vilazodone HCL side effects are incredibly rare, although it’s still possible for them to occur. Hair loss, various sexual abnormalities, and bleeding are reportedly present in a small number of patients.

Rare side effects of the medicine can also include:

  • tremors
  • agitation
  • appetite changes
  • nightmares
  • joint pain
  • panic attacks
  • mania
  • taste distortions

How Long Do Viibryd Side Effects Last?

Viibryd side effects go away in approximately 1-2 weeks after a person begins taking this medication. Most frequently, side effects cause mild discomfort and resolve without additional care when the patient adjusts to the drug. Such conditions as diarrhea, vomiting, and nausea go away after a couple of days. If they persist for longer, it’s necessary to contact a doctor. Some psychological risks, such as depression and the lack of energy, may need 6-8 weeks to start improving.

Some people quit the medication due to the unpleasant symptoms or Viibryd price without completing the course. This can sometimes cause negative impacts to grow. For instance, Viibryd mental side effects may include severe depression when the drug is stopped abruptly. However, when a patient continues taking the medication as directed by their doctor, the side effects usually diminish and eventually stop.

Viibryd and weight gain

Weight Changes On Vilazodone

Does Viibryd Cause Weight Gain?

One of the most feared Viibryd long-term side effects is weight gain. Depression frequently interferes with healthy eating patterns, forcing people to either overeat or disregard the need for nourishment. For some patients, gaining weight can be incredibly discouraging.

Vilazodone treatment is suitable for those who need to keep their weight stable. Viibryd weight gain is not detected in clinical trials, and only a small number of patients report experiencing it. The most common reason for gaining weight on vilazodone is the drug’s interaction with other medications that the person is taking.

Does Viibryd Cause Weight Loss?

Viibryd weight loss is very rare. Only 1.4% of patients experience a 7 or more percent decrease in their body mass during vilazodone treatment. Patients who struggle to stabilize their eating habits may find vilazodone insufficient, as it is not designed to produce significant weight changes.

sexual side effects of Viibryd

Sexual Side Effects Of Viibryd

Vilazodone sexual side effects can be present in men and women taking the antidepressant. The most common symptoms include:

  • decreased libido
  • inability to orgasm
  • insufficient lubrication in female patients
  • feeling less satisfaction from sex

Also, approximately 1.2% of male patients experience Viibryd erectile dysfunction. The sexual side effects of vilazodone tend to decrease over time. If they persist and cause significant distress, the person should contact their doctor to discuss possible solutions.

The Influence Of Vilazodone On People’s Sleep Patterns

Viibryd and sleep can have a disruptive relationship in some patients. The most common side effects of Viibryd that manifest in sleep issues include sleep paralysis, insomnia, nightmares, and night sweats. Normally, these adverse reactions are mild and resolve on their own after a couple of weeks. To avoid sleep issues connected to this antidepressant, the best time to take Viibryd is in the morning during breakfast.

Viibryd while pregnancy

Viibryd During Pregnancy & Breastfeeding

Can A Woman Take Viibryd While Pregnant?

Viibryd pregnancy category is C. It means that vilazodone has proved to be harmful to a degree in animal studies, but there isn’t enough data to gauge its hazardousness in humans. Harmful side effects of Viibryd are most likely to appear when the medication is used during the third trimester of pregnancy. A doctor can prescribe the drug if the benefits of the treatment outweigh the potential risks.

Can A Woman Breastfeed On Viibryd?

Using Viibryd during pregnancy and breastfeeding has limited risks. The medication is exerted into the milk, although the quantity is negligible. If a nursing mother ingests the prescribed Viibryd dose, the baby should not have any adverse reactions. If any side effects of vilazodone, such as agitation, irritability, or diarrhea, are noticed in the child, it is necessary to contact a medical professional.

Be Aware Of Viibryd Side Effects

As an SSRI antidepressant, Viibryd side effects are usually mild and go away quickly on their own. The most common adverse reactions to this medication include diarrhea, nausea, and sleep problems. If a person experiences diarrhea or vomiting for more than two days, it’s necessary to seek medical help, as both conditions can cause serious dehydration. Patients on vilazodone also sometimes experience hair loss and various sexual problems, including decreased libido and erectile dysfunction. Mental side effects of vilazodone can include anxiety, mania, and nightmares. Contacting a person’s doctor and correcting the course of treatment can help reduce the negative impacts and improve the patient’s condition.

The side effects may become worse when the medication is misused. A long term neglecting the prescription schedule may result in abuse and addiction. As soon as such behavior is noticed, it is critical to reaching professional rehab facilities. The staff in these centers will develop a personalized addiction treatment program to ensure fast and long-standing recovery.

Page Sources

  1. Morrison CM. A case report of the use of vilazodone in pregnancy. The Primary Care Companion for CNS Disorders. 2014; 16(2): PCC.13l01612. doi:10.4088/PCC.13l01612.
  2. VIIBRYD™ (vilazodone hydrochloride) Tablets: Highlights Of Prescribing Information. 2010.
  3. Supplement Approval. Food and Drug Administration. 2016.
  4. Cruz MP. Vilazodone HCl (Viibryd): A Serotonin Partial Agonist and Reuptake Inhibitor For the Treatment of Major Depressive Disorder. Physical Therapy. 2012; 37(1): 28–31.
  5. Liebowitz M, Croft HA, Kajdasz DK, et al. The Safety and Tolerability Profile of Vilazodone, A Novel Antidepressant for the Treatment of Major Depressive Disorder. Psychopharmacology Bulletin. 2011; 44(3): 15–33.

Published on: February 25th, 2020

Updated on: February 25th, 2020

About Author

Roger Weiss, MD

Dr. Roger Weiss is a practicing mental health specialist at the hospital. Dr. Weiss combines his clinical practice and medical writing career since 2009. Apart from these activities, Dr. Weiss also delivers lectures for youth, former addicts, and everyone interested in topics such as substance abuse and treatment.


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