Morphine Withdrawal Timeline and Symptoms

Morphine Withdrawal

Morphine is an opiate pain medication and it belongs to a class of drugs called opioid pain relievers. An opioid is also sometimes referred to as a narcotic. 

Morphine is used to treat moderate to severe pain. Extended release morphine capsules are used when around the clock pain relief is required. It is prescribed as a painkiller and it is highly addictive.

]Even when used appropriately, a patient can become addicted in as little as 2 weeks.

See if you qualify for Free Rehab. Receive free information today: 888-459-5511. Free and 100% Confidential HelpLine.

Addiction to this drug can quickly get out of control as over half of the drug-related deaths in the US are caused by morphine and heroin overdose. Because it is a depressant, the withdrawal symptoms can be excruciating. It is highly recommended that an addict goes through a substance medical detox where the withdrawal symptoms can be minimized in a safe place under the supervision of a medical doctor or other qualified healthcare professionals. These kinds of detox programs have been known to be safer, faster and more comfortable.

Addiction professional with a phone

Hope Without Commitment

Find the best treatment options.
Call our free and confidential helpline

Treatment Is Fully Covered by Insurance In Most Cases

Morphine Withdrawal Symptoms

After you stop taking morphine, you are going to have physical and emotional withdrawal symptoms that are all part of the process of detoxification. These symptoms are essentially manifestations of your brain and body adjusting to life without the medication. The physical symptoms can include nausea, vomiting, diarrhea, joint pain, insomnia, sweating, and flu-like symptoms.

The emotional or psychological symptoms are under appreciated but they are no less intense. They can come in the form of anxiety, dysphoria, irritability and a general inability to enjoy life. It is important to note that as morphine is an opiate, over time the body becomes accustomed to the effects of the drug and when absent the withdrawal symptoms will occur. This is the case even for people who use the drug legitimately, although the symptoms might not manifest as acutely as it will with chronic abusers. Withdrawal is a normal, predictable, physical and emotional response of the body to stopping the medication, but it can be extremely unpleasant and sometimes gets so uncomfortable that people go back to taking the drug just to relieve the withdrawal symptoms.

What to expect the first days of withdrawal

When you decide to go through with detox, you are going to experience the withdrawal symptoms as your body tries to adapt to this new circumstance. The morphine you have been taking has actually disrupted the balance of your brain chemistry and the body thus craves it when you take it away. These chemicals in your brain are depleted and you will become agitated.

You will experience irritability, skin crawls and you’ll feel like you have the flu a hundred times over. You will also experience watery eyes, body aches and you could develop a fever. You just end up being extremely uncomfortable and depressed. This is basically the overview of everything you will go through in the course of withdrawal.

When does it get better?

morphine withdrawal

Depending on how long you have been using and how much, the general rule is that you start to feel a little better after day 5. At this point, you will have experienced so much of the physical withdrawal symptoms and they will start to subside a little. The symptoms are still there but they won’t be as severe as they once were. At this point, however, you might find that you’re not getting any sleep and you are about to breakdown but you will eventually overcome this if you stay strong. After this stage, you start to feel somewhat better physically and psychologically and your motivation levels go up. As your brain tries to stabilize the already existing chemical imbalance you will feel yourself getting better and better as the days go on. However, don’t get discouraged when it feels like you’re relapsing as this is normal.

The withdrawal from morphine can be broken down into three phases each with its own specific characteristics.

Phase One

This is the phase right after you come off the drug say about 12 to 30 hours after your last use and you can experience any of the following symptoms; depression, nausea, cramps, diarrhea, insomnia. At this point, your body is basically reacting to the immediate absence of the drug it has become used to. It is the physical phase where you will go through most of the physical pain. However, this is not necessarily the hardest phase. This phase will last about 5 days to a week. You come out of it feeling a little bit better once you get to phase two.

Phase Two

At this point, your body is going to start working out most of the toxins that you have built up over the time period of your usage or abuse as the case may be. The less time you have been on the drug and the less quantity you have consumed, the easier this stage is going to be for you. It’s easier for the body to get rid of the chemicals and for your brain to reset to normal. This is the phase where it becomes very important to start supplementing and start taking vitamins and changing your diet and things like that. Phase two will last for about two weeks. As the body works to get rid of all the toxins, it also works to balance the endorphin levels that were depleted during the opiate addiction. Endorphins are depleted because as tolerance and dosage increases, the body ceases to produce its own natural endorphins. Symptoms that might be experienced at this phase include chills, sweating, goose bumps, dilated pupils, leg cramps, and restless leg syndrome.

Phase Three

This is a tough phase and this is where a lot of people run into problems. The symptoms here can be more psychological than physical but there will still be some physical pain and discomfort. Symptoms here include anxiety, restlessness, and insomnia. At this stage you have to be very careful because having gone through phase one and two, the urge to use becomes stronger than ever at this point and you risk losing all the progress you’ve made. This stage is critical as it determines whether or not you’re going to completely withdraw/detox from morphine.

Alleviating Morphine Withdrawal

Morphine withdrawal can be managed through the use of some drugs and medicines that help in reducing the morphine withdrawal effects. Some of these drugs and their mode of operation include:

  • Methadone: This drug works in almost the same way as morphine and produces similar effects albeit considerably lower in intensity. It is, however, much easier to kick than morphine is and the idea is to gradually reduce the dosage over a long period of time until the user can easily make the switch to cold turkey. Some people stay on methadone medication for many months before finally giving it up. It remains the most common withdrawal drug.
  • Buprenorphine: This drug works faster and can help detoxification from morphine much faster than methadone but it is also suitable for long-term use. It can be used with Naloxone without any problems.
  • Clonidine: This drug instead of relieving the cravings of morphine, helps to reduce the physical manifestations from the morphine withdrawal. Physical effects like aggressiveness, sweating, muscle aches and flu-like symptoms. It can be effective because it’s these physical symptoms that make morphine withdrawal very difficult.
  • Naltrexone: For people who fail their detoxification process at the third stage will benefit from this drug. It is meant to assist people from relapsing and giving in to the drug’s pull.

There are other alternative methods such as joining support groups, yoga, and exercise, that can be effective in relieving the symptoms from the withdrawal from morphine. At the very least, they provide a morale boost to help stay the course and not falter from the goal of kicking morphine addiction for good.


The withdrawal symptoms of morphine involve physical and emotional changes. You’re looking at anywhere from 2 to 3 weeks or the physical symptoms to completely disappear and 1 to 3 months for the emotional and psychological symptoms to do the same. The duration depends primarily on how long you have been using and at what levels. Most people continue to use because they are so scared of going through withdrawal. But with the right attitude and healthier habits, it becomes easier to live without morphine and you eventually won’t need it anymore.

Morphine addiction and withdrawal is a major issue because it affects so many people who aren’t necessarily trying to abuse the drug to start with. We have seen veterans who are suffering from posttraumatic stress disorders turn to morphine to help them get through their pains and flashbacks. Teens often out of curiosity also experiment with the drug and the body rapidly develops tolerance and they find themselves seeking more and more. Even medical professionals aren’t exempt from this addiction as they already have the access and they turn to the drug to help them deal with the stress and pressures of their demanding jobs. It is a massive global issue and if you find yourself or someone you care about going through this addiction, a lot of what you have read here will help you understand what is to come when they eventually begin to withdraw from the drug and hopefully you can better understand the phases.

Morphine Withdrawal Timeline and Symptoms

5 (100%) 1 vote

Comments 4

  • I am in Phase Three at this time and I will succeed in eliminating Opiates and finding pain relief using Kratom. Why do you not mention this herbal supplement?

  • My L4 & 5 discs are impinging directly on my spinal cord. I have low back and left leg pain around the clock. It happened when another car hit me while stopped at a red light. SJPD accident investigators determined he was going 46 MPH and zero braking. It Spine surgery failed. This happened in 2009 and it’s now in 2019. I’ve been on morphine extended relief pills for 10 years, and not missed a day taking it 2x’s in 24 hours. I’ve also been Rx’d OxyContin “quick release” pills 4x a day. I’ve known the withdrawal symptoms all along. The thought of withdrawal scares the S*** out of me. At this point along with the above symtoms, due to years of daily use for a decade. I’m also at risk of seizures. Benzos help a lot, but they’re addictive too…

  • I’m on day 6 with zero Morphine. I was on 15mg twicea day for over 5 years and was on one opiate or another for 9 years before that. I crushed 3 vertebrae in a fall from a ladder at work in 2005. They fused 7 verts together with 2 rods and 8 screws, put me on Hydrocodone and a Fentanyl patch and sent me home….. PT didn’t stop the pain, so they just kept me on opiates. I got tired of being treated like a drug addict by the VA, so I’m quitting!!

  • I need a hip replacement. tried all kinds of meds the only thing that helped was tyenol 3 with codeine and advil…my dr was not in favor of this regime ended up on morphine…took it for a week…than added a long term one,,,took ethem for four days!,,,,started itching,,,and just not feeling well…was decide I did not do well on morphine….I am so sick…can not believe how sick I am!…ONE WEEK…folks…this is horrible stuff…I will never take it again.

Leave a Reply

Your email address will not be published. Required fields are marked *