How Long Does Ketamine Stay In The System?
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How long does Ketamine stay in the system?
Ketamine has a short half-life of around 2.5-4 hours, which means that it takes about 13.45-16.30 hours to eliminate the drug from the system. Although Ketamine shouldn’t stay for more than 24 hours, some users need up to few days to get clean. Factors, such as metabolic rates and age, affect the duration and elimination of the drug.
Can One Tests positive for PCP after Ketamine intake?
No. Although Ketamine is an analog of PCP, one can’t get a false positive result. In general, standard tests do not detect Ketamine. Note that some specialized techniques can identify Ketamine (swab test – up to 24 hours, blood tests – up to two weeks, hair tests – up to 90 days, and urine tests – up to four days).
Ketamine is a potent analgesic that’s often abused due to its sedative properties. Nevertheless, standard drug tests do not detect Ketamine.
When it comes to powerful drugs, it’s important to know more about their duration and elimination. Ketamine half-life is 2.5-4 hours, which means one’ll need 13.45-16.30 hours to eliminate the drug from the plasma. Interestingly enough, children need only around 11 hours to get clean from the drug.
In general, most users need between 24 hours and a few days to clean their system from Ketamine.
Factors That Affect Ketamine Duration & Elimination
Like any other drug, the effects Ketamine has on people vary between individuals. Many factors influence the duration and elimination of the drug:
- History of abuse
- Overall health
- Metabolic rates
As Ketamine is metabolized by the CYP3A4 isoenzyme within the liver and as this enzyme is regulated by the CYP3A4 gene, it’s interesting to mention that some genetic differences affect the elimination of the drug.
Also, we should mention that Ketamine is lipophilic. That means that the drug accumulates in fat stores, which can lead to a lengthy elimination process.
How Is Ketamine Metabolized?
Ketamine is metabolized by the liver. Its primary metabolites are norketamine and dehydronorketamine, which have shorter elimination half-lives than Ketamine.
However, note that in patients with brain or spinal cord injury, these half-lives are longer when compared to Ketamine (5.3 for norketamine and 6.9 hours for dehydronorketamine).
As mentioned above, Ketamine is subject to hepatic metabolism. The drug undergoes N-demethylation via the CYP3A4 isoenzymes. Then, Norketamine forms the secondary metabolite – dehydronorketamine.
90% is excreted via urine and 3-5% via feces. Note that only 2-4% is unchanged Ketamine, which makes urinalysis not so popular.
Ketamine & Drug Testing
Although standard tests can’t detect Ketamine, some specialized techniques can find Ketamine in the body.
How Long Does Ketamine Stay In The Blood?
Although Ketamine has a short half-life, the drug can be detected in the blood for up to two weeks. However, blood tests for Ketamine are rare: they might be too expensive and time-consuming.
How Long Does Ketamine Stay In The Saliva?
Saliva tests are more popular and noninvasive when compared to blood tests. In fact, one can choose from various kits and purchase them online. Ketamine can be detected in the saliva for up to 24 hours.
How Long Does Ketamine Stay In The Hair?
Hair tests usually provide a longer window of detection (up to three months). Ketamine can be found in hair samples. The cut-off levels for Ketamine are 0.5 ng/mg and 0.1 ng/mg for norketamine.
How Long Does Ketamine Stay In The Urine?
Urine tests can detect Ketamine for up to four days and norketamine for up to two weeks. In fact, researchers claim that norketamine can remain detectable in monkeys for up to 31 days.
Note that although Ketamine is an analog of PCP, the drug won’t give a false positive test on standard drug tests.
To be on the safe side, do not mix drugs and take medications only as prescribed.
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