7 Strattera Side Effects from Common to Serious

Attention-deficit/hyperactivity disorder (ADHD) is a prevalent neuro-developmental disorder characterized by persistent patterns of inattention, hyperactivity, impulsivity, or a combination of these symptoms.

Individuals with ADHD often struggle with following directions or completing tasks. In the U.S., 6 million children and 8.7 million adults have been diagnosed with the disorder. Atomoxetine, marketed as Strattera, is the first-line treatment for ADHD with the great benefit of being non-addictive.

However, it is not without its adverse effects. Continue reading to learn about Strattera’s side effects, what to expect, and how to manage them.

Table Of Contents:

• Strattera Overview
• 7 Strattera Side Effects from Common to Serious
• Other Strattera Side Effects
• Strattera Side Effects − Bottom Line
• People Also Ask

Strattera Overview

Atomoxetine (Strattera) is the first non-stimulant medication to receive FDA approval for the treatment of attention-deficit/hyperactivity disorder (ADHD) in both children and adults.

Unlike traditional ADHD medications, atomoxetine is non-habit-forming due to its functions as a selective norepinephrine reuptake inhibitor. Clinical studies of atomoxetine have demonstrated a lack of abuse potential, making it a more secure option for the long-term management of ADHD. Yet, it may cause undesired symptoms during the treatment.

Let’s review seven side effects of Strattera:

7 Strattera Side Effects: from Common to Serious

The first and foremost important precaution about this medication is its boxed warning for suicidal ideation in children and teenagers. Clinicians must closely monitor patients starting on atomoxetine for unusual changes in behavior.

Here we provide a list for you to know what to expect if you or your child are under Strattera treatment:

Nausea and Vomiting

Nausea and vomiting are common side effects of Strattera, often occurring as the body adjusts to the medication. Atomoxetine influences norepinephrine levels, which indirectly increases dopamine levels. These levels later stimulate the chemoreceptor trigger zone (CTZ) in the brain, which is the information hub that induces nausea and vomiting.

If you are feeling nauseated after your Strattera pill, you can:

• Take the medication with food to reduce stomach irritation.
• Drinking enough water may prevent dehydration from vomiting.
• Use anti-nausea medications as prescribed by your healthcare provider.
• Eat small, frequent meals instead of large ones.

Dry Mouth

Dry mouth, or xerostomia, is a frequently reported side effect of Strattera users. Long-term use of Atomoxetine may increase the sensation of dry mouth and reduce salivation. These effects were observed after one month of daily doses of 60 mg/day to 120 mg/day.

To manage this effect, you can:

• Drink plenty of water throughout the day.
• Chew sugar-free gum or suck on sugar-free candies to stimulate saliva production.
• Use a saliva substitute or mouthwash designed for dry mouth.
• Avoid alcohol and caffeine, as they can exacerbate dryness.

Decreased Appetite and Weight Loss

This side effect can be particularly concerning in children. If you have noticed changes in appetite and weight, you may have wondered: Does Strattera cause weight loss? The answer is yes, but not by itself.

Weight loss on Strattera occurs due to a decreased appetite, probably due to the gastrointestinal problems mentioned before and the medication’s influence on norepinephrine pathways in the brain. The release of norepinephrine during stress activates a chain response that suppresses appetite.

To avoid losing weight:

• Eat nutrient-dense, high-calorie foods to maintain weight.
• Schedule regular meals and snacks, even if you don’t feel hungry.
• Monitor weight regularly and consult a dietitian if necessary.
• Ask your doctor to fix the initial dose from once to twice daily.

Does Strattera suppress appetite? Again, yes. It’s important to know that Strattera may affect growth rates in children. Yet, while it may be temporary, it may be reversible in the long term.

Headache

Headaches are a moderate side effect associated with Strattera. Since the medication can cause vascular changes, such as an increase in pulse and blood pressure, headaches may be a consequence. This side effect is dose-dependent.

To relieve your headache:

• Stay hydrated and aim for a regular sleep schedule.
• If approved by your doctor, use over-the-counter painkillers.
• Practice relaxation techniques such as deep breathing or meditation.
• Avoid triggers such as stress, caffeine, and visual overstimulation. Reduce screen time.
• Ask your doctor to fix your Strattera dose for the smallest effective one.

Fatigue

Fatigue is another moderate side effect. As atomoxetine may alter neurotransmitter levels in the brain, particularly norepinephrine, increase arousal and alertness, and promote vigilance, you may feel that your energy can be low within the first weeks of the treatment.

To make you feel better:

• Try to keep a consistent sleep routine. For a child, try short daytime naps.
• Eat a balanced diet to help you boost energy levels.
• Break tasks into smaller steps to manage workload effectively.
• Avoid driving or high-focus activities to prevent falls or injuries
• Discuss with your doctor if fatigue persists, as dose adjustment may be necessary.

Heart Problems

Prescribing atomoxetine in patients with hypertension, tachycardia, cardiovascular disease, or cerebrovascular disease requires caution. Like headaches, norepinephrine increases heart rate and blood pressure and appears dose-dependent. The effects decrease after stopping Strattera.

To make sure your health remains healthy during atomoxetine treatment:

• Monitor blood pressure and heart rate regularly.
• Avoid stimulants like caffeine or medications like muscle relaxers.
• Inform your doctor immediately if you experience chest pain, shortness of breath, or irregular heartbeats.
• Ensure regular follow-up appointments to monitor cardiovascular health.

Suicidal Thoughts

Suicidal thoughts are a very rare but severe side effect, particularly in children and adolescents. This side effect appeared in controlled trials but shouldn’t be underestimated. Atomoxetine may exacerbate underlying psychiatric conditions or cause mood changes that lead to suicidal ideation.

To guarantee the safety of the patient:

• Monitor for any changes in mood, behavior, or thoughts of self-harm.
• Maintain open communication with healthcare providers and family members.
• Seek immediate help if suicidal thoughts occur.
• Add therapy to support atomoxetine treatment.

Other Strattera Side Effects

Other adverse effects associated with Atomoxetine use include:

• Insomnia
• Dizziness
• Sweating
• Irritability
• Rash
• Sexual dysfunction

Most side effects are mild and disappear once your body adjusts to the medication. Don’t hesitate to contact your provider if you are experiencing more severe effects. If it’s an emergency, immediately call 911 or go to the nearest emergency room.

Strattera Side Effects − Bottom Line

As a non-stimulant option, Strattera is a valuable alternative to stimulant medications for the treatment of ADHD. Yet, it is not without side effects.

Common side effects, such as nausea, vomiting, dry mouth, decreased appetite, and weight loss, can be managed properly and will lessen throughout the treatment. If you are experiencing more severe side effects and are worried, talk to your doctor for a dose adjustment or an alternative.

If you or someone you know is struggling with ADHD, consult a healthcare provider to discuss whether Strattera might be a suitable option. Early ADHD intervention can lead to substantial improvements in your daily life.

People Also Ask

Does Strattera cause weight gain?

Weight gain is less common with Strattera. It more frequently causes weight loss due to its appetite-suppressing effects, though some patients might experience weight gain due to individual reactions.

Does Strattera make you lose weight?

Yes, Strattera often leads to weight loss by reducing appetite. This effect is more pronounced in the initial stages of treatment as the body adjusts to the medication.

How long do Strattera side effects last?

Strattera side effects typically diminish within a few weeks as the body adjusts to the medication. However, some side effects may persist; if they do not improve, they should be discussed with a healthcare provider.

Page Sources

1. Magnus, W., et al. (2023, August 8). Attention deficit hyperactivity disorder. StatPearls-NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK441838/
2. Wirth, J. (2023, August 24). ADHD statistics and Facts in 2024. Forbes Health. https://www.forbes.com/health/mind/adhd-statistics/
3. Camporeale, A., et al. (2013). Safety and tolerability of atomoxetine hydrochloride in a long-term, placebo-controlled randomized withdrawal study in European and non-European adults with attention-deficit/hyperactivity disorder. The European Journal of Psychiatry, 27(3), 206–224. https://doi.org/10.4321/s0213-61632013000300005
4. O’Brien, C. (2008, June 1). Nausea and vomiting. PubMed Central (PMC). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2426995/
5. Warren, C. M., Van Den Brink, R. L., Nieuwenhuis, S., & Bosch, J. A. (2017). Norepinephrine transporter blocker atomoxetine increases salivary alpha amylase. Psychoneuroendocrinology, 78, 233–236. https://doi.org/10.1016/j.psyneuen.2017.01.029
6. Fu, D., et al. (2022). The Mechanism, clinical efficacy, safety, and dosage regimen of atomoxetine for ADHD therapy in Children: A Narrative review. Frontiers in Psychiatry, 12. https://doi.org/10.3389/fpsyt.2021.780921
7. Pan, P., et al. (2021). Headache in ADHD as comorbidity and a side effect of medications: a systematic review and meta-analysis. Psychological Medicine, 52(1), 14–25. https://doi.org/10.1017/s0033291721004141
8. Herat, L. Y., et al. (2019). Sympathetic stimulation with norepinephrine may come at a cost. Neural Regeneration Research/Neural Regeneration Research, 14(6), 977. https://doi.org/10.4103/1673-5374.250576
9. Wooltorton, E. (2005). Health and Drug Alerts: Suicidal ideation among children taking atomoxetine (Strattera). CMAJ: Canadian Medical Association Journal, 173(12), 1447. https://doi.org/10.1503/cmaj.051474