Methadone Interactions – The Dangers Of Mixing Different Drugs

Addiction Resource > Addictive Substances: The Anatomy of Drug Addiction > Methadone Addiction and Treatment > Methadone Interactions – The Dangers Of Mixing Different Drugs

Methadone interactions concept image.

Mixing any drugs will always present a risk. This is no different when it comes to Methadone. Methadone interactions can be especially dangerous, due to the number of them Methadone has. Drug interactions with Methadone can cause serious health issues and cause both long and short-term problems. So what is that makes mixing drugs so dangerous? And why would someone decide to take a drug with so many possible interactions?

Addiction professional with a phone

Hope Without Commitment

Find the best treatment options.
Call our free and confidential helpline

Treatment Is Fully Covered by Insurance In Most Cases

What Causes Tramadol and Methadone Use?

Bottle at forefront with Methadone written on it.

Methadone is a substance that has very similar effects to Morphine. However, it is slightly longer lasting. This prescribed drug is a well-known opioid that is commonly used to treat pain and sometimes addictions such as heroin. Despite all these positive effects, it doesn’t mix well with other substances.

Mixing Methadone with other drugs can have dangerous side effects. For example, Tramadol and Methadone do not go well together at all. The two substances combined can have drastic health effects on the user, such as seizures and respiratory issues. They have even been known to cause comas, or even death on occasions when combined.

Other side effects of Tramadol and Methadone being combined are:

  • Nausea
  • Sweating
  • Mood Swings
  • Depression
  • Convulsions
  • Appetite Changes
When it comes to Methadone drug interaction, the interaction with Tramadol is one of the worst because of how deadly it can be. Mixing these drugs should be avoided without exception.

What Makes Mixing Drugs So Dangerous?

Mixing substances, in general, is dangerous. Many users do not check drug interactions before combining them, which can make the consequences all the more challenging to deal with. Due to the number of interactions any substance can have, it is a risk to mix without checking.

Mixing substances can lead to both short-term and long-term health issues. It can also in extreme cases lead to a coma or even death. This highlights the importance of knowing what you are taking, and how it interacts with other drugs.

Mixing drugs doesn’t only create physical health issues but can also affect the user psychologically. This is even more evident if depressants are mixed with stimulants. This mixture of substances causes two opposing effects on the body and mind, creating highly problematic health issues such as psychosis, mood swings and severe depression.

The Effects of Mixing Methadone With Other Drugs

Methadone drug interactions are no exception when it comes to potential danger. There are hundreds of different drugs that interact with Methadone to varying degrees, all of which can cause severe discomfort to the user.

Amongst the hundreds of substances that have severe interactions with Methadone, are Codeine, caffeine, and Ativan. These drugs and hundreds of others could have severe effects when mixed with Methadone and therefore should be avoided.

Severe reactions from mixing other substances with methadone can include anything from a nauseated feeling to severe respiratory issues such as shallow breathing or even slipping into a coma.

How To Get Help For Polydrug Abuse

If you are someone who regularly abuses a variety of substances, then you could be at risk of suffering from drug interactions. Polydrug abuse is very dangerous and is often a sign of addiction. It is important to get immediate medical help if you notice the signs of abuse in yourself or another.

The Lists of Methadone Drug Interactions

Mixture of colored tablets scattered on surface.

As with any substance, Methadone interactions come with different levels of severity. This Methadone drug interaction chart will help to clarify how severely Methadone interacts with others.

Severe Interactions

  • Methadone and antibiotics – Some antibiotics have severe interactions 
  • Codeine – Nausea, seizures and sometimes death
  • Caffeine – Breathing difficulties and seizures
  • Ativan – Breathing difficulties, nausea, seizures and worse
  • And More

Serious Interactions

  • Alfentanil
  • Amphetamine
  • Lanolin
  • Labetalol
  • Kaolin
  • And More

Moderate Interactions

  • Rifabutin
  • Gantanol
  • Indinavir
  • Donepezil
  • Gabapentin and Methadone 
  • Wellbutrin And Methadone

According to the US Food and Drug Administration, drugs can also interact with medical conditions, foods, and drinks. This means if you are having a reaction to Methadone, and you know it isn’t related to a drug interaction then it could be for one of these other reasons.

Methadone – The Alternative To Mixing

If you are using Methadone, and need to use another drug for medical reasons, there may be similar alternatives to that drug for your use. In addition to alternative drugs, there are also natural alternatives. These options will help you to avoid the worst interactions. Another option is to find an alternative to the substance that will not interact with the other drug you need to use.

For more details on suitable replacements, it is a good idea to contact a health professional, such as your doctor. They may also be able to recommend a suitable rehab for Methadone for you to avoid drug use altogether. This will allow your body to recover completely from drug abuse and prevent any further mixing of drugs.

Addiction professional with a phone

Hope Without Commitment

Find the best treatment options.
Call our free and confidential helpline

Treatment Is Fully Covered by Insurance In Most Cases

For any further advice on where to get treatment, or finding the suitable treatment for you, call our hotline at (888)-459-5511.

Methadone Interactions – The Dangers Of Mixing Different Drugs

Rate this article



Leave a Reply

Your email address will not be published. Required fields are marked *