Ayahuasca Effects – What Every Ayahuasca User Should Know

Last Updated: December 18, 2019

In recent years, Ayahuasca has gained much acclaim and notoriety as a tool for “spiritual healing” however the potent hallucinogenic has a number of significant side effects..
It would be advise to anybody interested in experimenting with an Ayahuasca experience to really study how it will effect your body and mind. This is not a party drug but a very strong hallucinogen.

Ayahuasca Side Effects

Ayahuasca is made up of two ingredients native to South America which come from the psychedelic Psychotria Viridis plant (or Diplopterys cabrenana) and the stems and bark of Banisteriopsis caapi. Together they form a psychedelic brew which is consumed orally like tea. Drinking the mixture makes the Ayahuasca effects and side effects less intense than smoking or injecting the active ingredient.

Doctors classify DMT as an entheogen but the exact understanding as to how DMT acts as such a potent psychedelic or entheogen is still unknown. Currently all the scientific community know is the brain naturally produced DMT in the pineal gland.
The primary reason why users are interested in experiencing the drug is for what some believe to be profound psychological effects.
Usually users of Ayahuasca consume the drug in a ceremonial setting in its country of origin thus it is not a regular recreational psychedelic and few will ever have the opportunity to experiement.

What are the Ayahuasca Psychological Adverse Effects?

Let’s take a look at the most prominent of the Ayahuasca effects. The Ayahuasca ‘trip’ has a very profound psychological impact on the user which can be either a very good experience or very bad and research into Ayahuasca use has not very rarely provide any ‘neutral’ experience.

Visual and Auditory Hallucinations

Sometimes users are referred to as ‘psychonauts’ due to the extreme Ayahuasca effects of such a potent psychedelic. Many users of the drug report:
Ayahuasca Effects

  • Disturbances and ‘changes’ in their visual surroundings
  • Colors and details intensify, especially within natural surroundings
  • Changes in perceptions of time: where it either speeds up or slows down
  • Hallucinations usually have a theme: often that of ancient civilizations (for instance Aztec, Mayan or Olmec), futuristic (including alien technology and beings) or where it personifies nature itself (as Gaya, or ‘mother nature’ in Western terms)
  • Open-eye hallucinations, where phantom images spontaneously appear
  • Closed-eye hallucinations are claimed to be more profound where the drug transports the user to a different setting in time and space.
  • Many users have out-of-body experiences
  • Intense powerful vibrations of the physical environment felt in the body
  • Auditory hallucinations also include spontaneous open-eyed and closed-eyed experiences
  • Auditory hallucinations are likened to a “crinkling sound, like cellophane”, “chattering”, or a high-pitched “whining and whirring”
  • Synesthesia is frequently reported (where sights are heard and the person can also visualize sounds)
  • Depersonalization (an experience in its most acute form known as “ego death”)

In terms of auditory and visual hallucinations, they say getting high on Ayahuasca is similar in effect to other psychedelics such as magic mushrooms, LSD, peyote, and mescaline.although Ayahuasca is exceptionally more potent though.

Improved Mood (‘good trips’)

Ayahuasca may produce intense feelings of elation and euphoria which is connected to the ‘spiritual journey’ aspect of the experience. User accounts of positive experiences liken it to a ‘spiritual birth’ or ‘spiritual rebirth.’
Those who have consumed Ayahuasca warn that “the drug is not for everybody” as the intensity of the brew can evoke a very negative experience, especially in those with pre-existing emotional or psychological conditions like schizophrenia.

Worsened Mood (‘bad trips’)

Many users report a journey into past traumatic events but viewed as a bystander almost like an out-of-body. The intense nature of the experience may evoke feelings of fear, paranoia and emotional hurt whilst one revisits these events. It is not uncommon for users who have these negative experiences to consume the drug again as a way to confront these past events in an attempt to ‘set things right.’

Persistent Psychosis and Hallucinogen Persisting Perception Disorder (HPPD)

Persistent Psychosis is where users of a drug encounter continued emotional problems after consuming a drug, such as:

  • Paranoia
  • Changes in general mood
  • Confused or disorganized thinking

Hallucinogen Persisting Perception Disorder is where, after drug consumption, users suffer from:

  • Visual disturbances, for instance seeing trails attached to moving objects
  • Hallucinations
  • Symptoms of other neurological disorders

Emotional Repair

This is the most prominently cited reasons for taking Ayahuasca as has been advertised on dozens of websites for Ayahuasca retreats. These can include:

  • Overcome past traumas, often from childhood, early adolescence or pain experienced in close relationships as children or adults
  • Epiphanies or greater insight into personal habits, behaviors, and patterns
  • Overcome substance abuse problems

Common Ayahuasca Side Effects

The drug has a marked effect on the body and as a result users will find themselves unable to perform complicated tasks as most experiencing a Ayahuasca high become incapacitated. Therefore, many are susceptible to environmental dangers, which should be kept  in mind if taking Ayahuasca outside within nature.

Physical Side Effects of Ayahuasca

The Ayahuasca effects on the body include:

  • Nausea
  • Vomiting
  • Diarrhea (when taken in a ceremonial setting, shamans or ayahuasqueros provide instructions mitigating or avoiding this effect)
  • Dilated pupils
  • Double vision (In rare instances) where the eyes have trouble focusing
  • Uncontrolled rapid eye movement
  • Disturbances with in depth perception
  • Increased blood pressure and heart rate or even chest pain (at very high doses)
  • Fever-like symptoms (in very high doses)
  • Decreased motor skills and coordination
  • Dizziness

Tolerance and Physical Addiction

The National Institute on Drug Abuse (NIDA) advises the need for further research to determine whether DMT is physically addictive although current research suggests that users are not able to develop any tolerance for the drug.

Is Ayahuasca Lethal?

In August of 2012, there was a report of an 18-year-old Californian man who died from consuming a lethal dose of Ayahuasca while attending a Peruvian Ayahuasca retreat. Unfortunately, the size of the lethal dose was not.

The rising media attention given to Ayahuasca makes it unlikely for the drug to disappear from Western society. Furthermore, there needs to be much more research before DMT is fully understood.

Page Sources

  1. https://en.wikipedia.org/wiki/Banisteriopsis_caapi
  2. https://www.drugabuse.gov/drugs-abuse/commonly-abused-drugs-charts

Published on: May 5th, 2017

Updated on: December 18th, 2019

About Author

Peter J. Grinspoon, MD

Dr. Peter Grinspoon is an experienced physician with long-term clinical practice experience. As a former analgesic addict, Dr. Grinspoon knows precisely how important it is to provide patients with effective treatment and support. Medical writing for him is the way to communicate with people and inform them about their health.


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  • Francisco Zapata
    La información está muy buena y completa, pero el artículo no presenta quién es el autor, fecha de publicación ni referencias. Se hace difícil citarlo como referencia en algún trabajo sin esa información. Gracias!