Clonidine Interactions With Other Medications

Last Updated: March 16, 2020

Authored by Isaak Stotts, LP

Clonidine interactions will change the way medications work and possibly increase your risk for serious side effects. These often occur when one mixes Catapres with other drugs and substances, including alcohol, weed, herbs, and supplements. Each of the following Catapres interactions should be considered before starting taking the medications to avoid unpleasant reactions.

Clonidine And Alcohol Interaction

When mixed, Catapres and alcohol can lead to adverse reactions. This interaction can be dangerous enough to make the patient’s life uncomfortable.

Mixing clonidine and alcohol will cause fluctuations in blood pressure, headaches, nausea, and vomiting. Liver problems are also common among patients who drink alcohol while taking clonidine for a long period of time. In severe cases, seizures, loss of consciousness, heart attack, stroke, coma, or even death may occur.

clonidine and alcohol

The medication is often abused with alcohol by people who are addicted to opiates. Aside from wanting to prolong clonidine euphoria, abusers take Catapres with alcohol to save money from not buying the more expensive illicit drugs to get high. Evidence shows that 14 out of 15 patients suffering from opiate addiction are abusing Catapres. These people often get the prescription for clonidine (Catapres) easily because it is not a controlled substance. Another study state that addicts undergoing methadone maintenance program abuse Catapres not only for withdrawal purposes but the sedating effect as well.

Clonidine And Weed Interaction

One of the most dangerous Catapres interactions involves cannabis. Using clonidine pill with weed may increase side effects such as confusion, dizziness, drowsiness, and difficulty concentrating. Some people, including the elderly, are prone to experiencing impairment in thinking, judgment, and motor coordination.

weed and clonidine

Catapres Interactions With Other Medications

It is worth to highlight that Catapres interacts not only with illegal substances but with prescription medications, too. It means that the patients should keep caution when taking Catapres and inform their doctor about any other meds before prescribing Catapres.

Clonidine And Xanax Interaction

CNS and respiratory depressant effects are increased in patients taking Catapres and Xanax concurrently. Aside from amplifying clonidine HCl side effects, patients may suffer impairment of attention, thinking, judgment, and psychomotor skills, especially the elderly, and debilitated patients.

Clonidine And Adderall Interaction

Clonidine interaction with Adderall will require close monitoring of blood pressure or the selection of alternative drugs. Adderall increases both systolic and diastolic blood pressure and may counteract the activity of Catapres. Patients need to inform doctors about all the drugs being taken simultaneously.

Clonidine And Metoprolol Interaction

One major clonidine drug interaction involves metoprolol. When used together, these drugs will lower blood pressure and slow heart rate. Bradycardia, dizziness, headaches, fainting, are also common.

Clonidine And Suboxone Interaction

Mixing Catapres and suboxone has additive effects. One may suffer from extremely low blood pressure, headaches, dizziness, lightheadedness, fainting, weakness, and changes in heart and pulse rates. These adverse effects are often observed among new users, after a dose adjustment or when treatment is restarted. Also, suboxone can affect clonidine withdrawal syndrome if the drug is used for treating opiate addiction.

catapres with other drugs

Guanfacine And Clonidine Interaction

Clonidine interactions with other drugs may sometimes cause life-threatening complications. Combined Guanfacine and Catapres may cause excessive slowing of heart rate that can sometimes lead to serious cardiac conditions.

Clonidine And Vyvanse Interaction

Vyvanse poses the same risks as that of Adderall when used simultaneously with Catapres. However, the individual features can impact the severity and duration of the symptoms, as well as their manifestation.

Clonidine And Methadone Interaction

The reactions observed when one combines Catapres and methadone are similar to those of suboxone. Still, each case is unique; it means that reactions of the patients’ organisms may vary.

Clonidine And Gabapentin Interaction

Gabapentin must be given at the lowest recommended dose during co-administration with Catapres. These drugs will cause additive CNS depression. Patients must consult a doctor for proper education on the possible symptoms and risks.

Clonidine And Klonopin Interaction

Clonidine MOA can potentiate the actions of other CNS depressants, including benzodiazepines like Klonopin.

Clonidine And Ibuprofen Interaction

Careful monitoring of patients for signs and symptoms of renal insufficiency and blood pressure control is required if nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and Catapres are used together. One may suffer from high blood pressure, peripheral edema, and weight gain. NSAIDs may also cause renal insufficiency because of a reduction in renal blood flow. As a result, the time how long clonidine stays in one’s system may increase.

Be Aware Of Potential Interactions

When the drug is taken with other medications, the patients are at risk to experience unpleasant and even dangerous reactions. Especially it is true when Catapres is mixed with illegal drugs. Such behavior is a signal of abuse and requires appropriate measures to be taken. The professional drug rehabilitation centers help addicts to beat their cravings and stay sober for a long time. Because treatment should be individualized, the staff designs the drug addiction treatment to meet the needs of each patient.

Page Sources

  1. Dennison SJ. Clonidine abuse among opiate addicts. Psychiatric Quarterly. 2001; 72(2): 191-5.
  2. Beuger M, Tommasello A, Schwartz R, Clinton M. Clonidine use and abuse among methadone program applicants and patients. Journal of Substance Abuse Treatment. 1998; 15(6): 589-93.

Published on: March 16th, 2020

Updated on: March 16th, 2020

About Author

Isaak Stotts, LP

Isaak Stotts is an in-house medical writer in AddictionResource. Isaak learned addiction psychology at Aspen University and got a Master's Degree in Arts in Psychology and Addiction Counseling. After graduation, he became a substance abuse counselor, providing individual, group, and family counseling for those who strive to achieve and maintain sobriety and recovery goals.


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