What Is Vyvanse Withdrawal And Detox? How To Deal With It?

Last Updated: January 21, 2021

Authored by Isaak Stotts, LP

Reviewed by Michael Espelin APRN

Upon getting off Vyvanse use, certain withdrawal symptoms set into the body because of a change in the neurochemistry of the brain. These symptoms of Vyvanse withdrawal can be intense particularly if there already was a dependency on the drug. Therefore, it is important to know how to manage these symptoms including Vyvanse crash.

Signs And Symptoms Of Vyvanse Withdrawal

The following lisdexamfetamine withdrawal symptoms are likely to occur once the use of Vyvanse has been stopped or the amount of dosage is not enough for the patient:

  • Anxiety
  • Feeling of fatigue and tiredness
  • Lack of sleep
  • Feelings of depression
  • Irritability
  • Intense craving
  • Headache
  • Mood swings
  • Lack of motivation
  • Increased appetite
  • Uncontrollable body shakiness
  • Lethargy

If the dosage is not effective, consulting a physician is a sure way to get the right dosage. Furthermore, the physician will know how to make Vyvanse more effective, therefore, relieving these symptoms. It may also be as a result of tolerance to the drug over time.

Vyvanse Withdrawal Timeline

Not everyone who stops using Vyvanse experience withdrawal or a crash at the same time or in the same way since different people react differently. Those who have used the drug longer are likely to experience more significant detox symptoms and take longer to detox. Some of the early withdrawal symptoms are:vyvanse withdrawal symptoms

  • Strange thoughts
  • Strong urge to take the drug
  • Increased appetite
  • Fatigue
  • Depression
  • Body aches and pain
  • Sudden mood swings

After about seven days these symptoms may reduce. However, the patient may still experience the following symptoms:

  • Inability to sleep
  • Anxiety
  • Mood swings
  • Low energy levels
  • Mood swings
  • Occasional Psychosis

Increased Severity Of Withdrawal Symptoms

Lisdexamfetamine detox symptoms can be experienced with greater severity depending on factors such as the length of drug use, the usual dosage amount taken, and frequency of use. These factors are controlled by how long Vyvanse stays in blood. Those who take higher doses several times daily for a long period are more likely to experience severe withdrawal and crash symptoms as opposed to those who take lower, long-interval doses.

How To Manage The Symptoms?

If there is severity of symptoms, users should consider tapering rather than cold turkey technique. Once tapering has been adopted, the user should always stay hydrated by taking plenty of water and eating a healthy-balanced diet even if there is a lack of appetite. Despite the lack of appetite, being one of the signs of Vyvanse abuse and detox, a proper diet will replenish the body’s energy levels.

Vyvanse Crash

Since Vyvanse is a stimulant drug, the chemical elements in the drug stimulate the central nervous system causing an increase in production of dopamine and norepinephrine. Once the use of lisdexamfetamine is stopped, the drug starts to leave the body. Therefore, its effects begin to wear off causing the Vyvanse comedown symptoms. After this happens, feelings opposite to stimulation occur such as fatigue and irritability. This is what is called lisdexamfetamine crash.

What Causes Vyvanse Crash?

Lisdexamfetamine (Vyvanse) is used to treat attention deficit hyperactive disorder. Therefore, once the drug has worn off, there will be a diminishing of the functions of neurotransmitters in the brain. In short, after the drug has left the body, the levels of dopamine go down. This causes the Vyvanse crash depression. Normally, this condition is common late in the day because lisdexamfetamine is taken early in the morning. However, it may also occur during the day if the morning dosage is missed making Vyvanse take a longer time to work on the next dosage.

Stopping Vyvanse Use

There isn’t any medical treatment of Vyvanse withdrawals symptoms; however, there are certain dietary and hydration regimen that can be used to manage the symptoms. Hence, knowing when and how to stop taking Vyvanse is important. Once some side effects start showing, it is an indication that someone should stop taking the drug. In addition, lisdexamfetamine should be stopped if the drug does not work well with the patient’s brain chemistry.

Techniques Used To Stop Taking Vyvanse

Cold Turkey

stop vyvanse cold turkeyThis technique of withdrawals management involves the abrupt stopping of Vyvanse use. The patient does not decrease the dose gradually. Stopping lisdexamfetamine abruptly will likely lead to the onset of withdrawal symptoms. Therefore, this method can be used to monitor the Vyvanse withdrawal timeline of a patient.


Tapering is when a patient gradually stops taking drugs by increasingly reducing the dosage. It helps manage the lisdexamfetamine comedown symptoms to a certain extent. This method is helpful even for users who snort Vyvanse. A patient getting off lisdexamfetamine should consult a medical doctor before tapering because a doctor can advise on the dosage to take gradually as they monitor the outcome. The doctor will also advise on the possibility of a Vyvanse crash, how to prevent it, and what to do when it happens.

Withdrawal Treatment And Detox

With stimulants like Vyvanse, there are currently no approved withdrawal medications that can be used. Instead, symptoms are treated with particular medication once they arise. This is in the case where the lisdexamfetamine user is in a rehabilitation center under the supervision of the professionals. The professional help is to understand how to get Vyvanse out of one’s system safely.


Antidepressants and Mirtazapine can be used to treat withdrawal-induced Vyvanse depression, while benzodiazepines and antipsychotics are used to control irritability and agitation symptoms. Although this medication can be effective, care should be taken to prevent dependency. Therefore, these medications should be prescribed for a period of between 7 to 10 days under the watchful eye of qualified health staff. Nevertheless, the treatment in a rehabilitation center is the best answer on how to stop taking Vyvanse. It sets out on a clear path that is free of the drug and its effects.

Choosing Vyvanse Rehabilitation Center

The cost, success rates, therapy offered, quality and availability of staff are some of the factors to consider when choosing a rehabilitation center. The two options in rehabilitation centers include an inpatient program as well as an outpatient program. Health care providers may recommend an inpatient treatment for certain patients more to those with symptoms, despite it is more expensive than outpatient. However, it is important to realize that Vyvanse cost without insurance (or with) is much cheaper than addiction costs.

Seeking For Help

Once there is a stoppage of using Vyvanse, certain withdrawal symptoms may occur, depending on the frequency of use, length of use and amount of dosage. Although there may not be specialized medication to treat these withdrawals, specific medication can only be administered by a professional to manage withdrawals. It is, therefore, important to seek professional addiction treatment.

Page Sources

  1. https://www.sahealth.sa.gov.au/wps/wcm/connect/public+content/sa+health+internet/clinical+resources/clinical+topics/substance+misuse+and+dependence/substance+withdrawal+management/amphetamine+withdrawal+management

Published on: April 1st, 2019

Updated on: January 21st, 2021

About Author

Isaak Stotts, LP

Isaak Stotts is an in-house medical writer in AddictionResource. Isaak learned addiction psychology at Aspen University and got a Master's Degree in Arts in Psychology and Addiction Counseling. After graduation, he became a substance abuse counselor, providing individual, group, and family counseling for those who strive to achieve and maintain sobriety and recovery goals.

Medically Reviewed by

Michael Espelin APRN

8 years of nursing experience in wide variety of behavioral and addition settings that include adult inpatient and outpatient mental health services with substance use disorders, and geriatric long-term care and hospice care.  He has a particular interest in psychopharmacology, nutritional psychiatry, and alternative treatment options involving particular vitamins, dietary supplements, and administering auricular acupuncture.


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