Vyvanse In The System: Passing Drug Tests On The Medication

Last Updated: June 3, 2020

Authored by Isaak Stotts, LP

Reviewed by Michael Espelin APRN

Drug tests are used in a variety of settings, from employers making sure their employees are representing them well to parents making certain their kids are staying clean. Some prescription medications can show up on these drug tests because they are amphetamines, including Vyvanse for ADD. How long does Vyvanse stay in one’s system? Here is important information about Vyvanse drug testing.

Vyvanse Half-Life

Someone who is abusing the drug is likely to be experiencing mental health effects, including Vyvanse anxiety. This can make worries over drug testing extra troubling. Understanding science can help.
Half-life is one of those medical terms many people use but few understand. Often thought to mean how long half the medicine remains in the system as a whole. It actually references how long it takes for half the drug to be eliminated from the plasma of the blood. So, when speaking about Vyvanse half-life, what is specifically being referenced is how long it takes for the blood plasma levels of the drug to reach 50 percent. Higher concentrations can remain in other body elements for much longer.

Duration Of Vyvanse Half-Life

The Vyvanse half-life is short. Considering how long Vyvanse 70 mg lasts, it’s worth saying that the medication itself is not in the system long. The half-life for it in the blood plasma is less than one hour. Complete clearance of the primary ingredient, lisdexamfetamine, occurs in under six hours. Most of the drug is excreted through the urine, though a small portion is eliminated through feces.
To those questioning how long does Vyvanse stay in the system, this sounds like good news. But it is a bit misleading. While the medication itself may be eradicated from the system in six hours or less, the metabolites will remain. For those wondering whether Vyvanse shows up on a drug test, the answer is yes, and it is the metabolites that are tested for.


When the primary ingredient metabolizes, it turns into dextroamphetamine and L-Lysine. Dextroamphetamine has a longer half-life than lisdexamfetamine, coming in at around 11 hours. This means that full excretion of the medication and its metabolites from the system is roughly two-and-a-half days. In other words, for drug testing purposes, the half-life of Vyvanse should be considered to be 11 hours, not less than one hour. This is assuming the user is taking the Vyvanse max dose as recommended by the FDA and not exceeding it.

Variables Influencing How Long Vyvanse Remains In The System

how long does it take for vyvanse to get out of your systemIf someone has a prescription for Vyvanse, they should not worry about passing drug tests. If they are able to present a valid, legal prescription for the medication, they will not run into problems in the majority of circumstances. It is those who are taking it without a valid prescription, especially those addicted to Vyvanse, that need to be concerned about having it detected in their system
People who are worried about how long Vyvanse time release remains in the system need to know about the variables that can influence this. Usually, they are looking for how to make Vyvanse wear off faster. However, not all variables that affect how long Vyvanse lasts in the system can be altered.
While the half-life of the drug has been determined through clinical tests, it is an average of all of those who were part of the trials. For some people, the half-life is reached faster, while others will reach it slower. This means that Vyvanse drug test detection time is highly individual based on factors that include:

  • Age
  • Weight
  • Ratio of body fat to muscle
  • Activity levels
  • Hydration levels
  • Frequency of use
  • The dose of the drug taken
  • Drug tolerance
  • Medical conditions
  • The type of drug test being taken
  • Other drugs being taken—Vyvanse drug interactions can result in longer detection times

As such, no online guide can tell someone exactly how long it will take to get Vyvanse out of their system. All numbers are approximate.

How Long Does Vyvanse Remain In The Urine, Blood, And Hair?

There are multiple ways drugs can be tested for. However, the most common are urine, blood, and hair tests. How long Vyvanse is in one’s system will vary depending on what is being tested. If the person knows in advance when they will be tested and through what method, it can be easier to beat the exam.

Urine Testing

Vyvanse may not always show up on a urine test. If the test is for amphetamines, it can be detected. A Vyvanse urine test is the most likely one to be used. This is because it can detect the presence of the medication’s metabolites for a greater period than blood and it is a cheap test to administer. Results are instant, allowing the tester to get their answers quickly. Vyvanse in urine is detectable for up to four days.

Blood Testing

how long does vyvanse stay in your bloodBlood testing for amphetamines is highly accurate. However, it is more difficult and more expensive than urine testing. It is also less likely to catch the use of the drug if it is not being used frequently. Speaking about how long Vyvanse stays in the blood, it remains detectable for approximately 12 hours, which means the window for testing is relatively small. This is because the body’s filters remove it from the blood quickly, transferring it to the urine and feces.

Hair Testing

Hair testing for Vyvanse, as well as other drugs, is expensive to complete, and as such is rare. However, it is where there is the greatest risk for a positive result. When talking about the majority of the body, it is mere days, but when it comes to the hair, Vyvanse and other amphetamines can remain present and detectable for as long as three months.

How To Speed Up System Cleaning

Those worried about how to pass a drug test for Vyvanse can look for ways to speed up system cleaning. There are no specific methods for how to get Vyvanse out of the system, but there are methods that are used for flushing out drugs in general that can help. These include:

  • Drinking extra water—about 2.7 liters in a day for women and 3.7 liters in a day for men
  • Consume antioxidant-rich drinks, 2-3 cups per day—things like tea, cranberry juice, and detox drinks
  • Avoid any alcohol until the drugs are fully out of the system as it can delay excretion
  • Perform aerobic activities with the goal of sweating out the drug
  • Spend 30 minutes a day in a sauna
  • Take a bath with Epsom salts
  • Eat healthily, so the body is not taxed with processing other toxic elements
  • Increase fiber intake to promote the excretion of the drug through feces

Anyone attempting these quick fixes must take care not to dehydrate. It is also important to note that the easiest way to pass a test is not to use drugs in the first place.

Getting Clean From Vyvanse

Anyone who is worried about passing a drug test for Vyvanse is likely misusing the medication and in need of help. While looking into natural alternatives to Vyvanse is a good idea, the best course of action is to seek help. Drug rehabilitation centers can help those addicted to Vyvanse get clean and live a better life. There are many addiction treatment programs which help addicts to recover.

Page Sources

  1. https://www.ncbi.nlm.nih.gov/pubmed/18991468
  2. https://pubchem.ncbi.nlm.nih.gov/compound/dextroamphetamine

Published on: April 1st, 2019

Updated on: June 3rd, 2020

About Author

Isaak Stotts, LP

Isaak Stotts is an in-house medical writer in AddictionResource. Isaak learned addiction psychology at Aspen University and got a Master's Degree in Arts in Psychology and Addiction Counseling. After graduation, he became a substance abuse counselor, providing individual, group, and family counseling for those who strive to achieve and maintain sobriety and recovery goals.

Medically Reviewed by

Michael Espelin APRN

8 years of nursing experience in wide variety of behavioral and addition settings that include adult inpatient and outpatient mental health services with substance use disorders, and geriatric long-term care and hospice care.  He has a particular interest in psychopharmacology, nutritional psychiatry, and alternative treatment options involving particular vitamins, dietary supplements, and administering auricular acupuncture.


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