Weaning Off Effexor: How To Stop Taking Effexor

Last Updated: December 19, 2019

Authored by Nena Messina, Ph.D.

Weaning off Effexor can be difficult for patients who are doing it because they are switching to another drug or if the Effexor is not required anymore. Even though venlafaxine is not physically addictive, stopping is hard because patients can experience some Effexor horrible side effects. It is for this reason, therefore, that it is advisable to gradually wean off venlafaxine rather than going cold turkey.

Side Effects Of Coming Off Effexor

People buy venlafaxine to treat major depressive disorders and anxiety. Although venlafaxine has its advantages in managing the disorders, some patients might find a reason to stop Effexor. However, stopping venlafaxine without the knowledge of the concerned medical personnel can result in side effects that are harmful to health.

The side effects of coming off Effexor vary among the different patients. For some, they might be mild to almost nonexistent, whereas others might experience the severity of stopping Effexor cold turkey. The Effexor classification of drugs alters the number of neurotransmitters. When patients quit Effexor, the brain has to readjust to the new amounts of neurotransmitters, causing the side effects.

effexor withdrawal symptom

These side effects include:

  • increased depressive episodes
  • anxiety
  • recurrence of panic attacks
  • headaches
  • nausea
  • tinnitus – a ringing sound in the ear
  • dizziness
  • insomnia
  • tingly sensations on the skin
  • feelings of electric shocks in the head

Effexor Tapering

As highlighted, stopping the use of venlafaxine can cause some undesirable side effects. Tapering off Effexor is, therefore, the recommended course of action instead of stopping Effexor suddenly.

Successfully stopping venlafaxine will depend on the Effexor dosages that the patient has been taking. Doctors also take into consideration any health incidents that occurred during the last time the patient was in the process of weaning off venlafaxine. According to an article in Harvard Health, Effexor tapering usually occurs in 4 stages of decreasing doses. There is no set time interval until the next interval because it depends on how the individual responds to the dosage.

Typically, one the first dose reduction would be from 300 mg of venlafaxine to 225 mg. This would then be reduced further to 150 mg after a period that the doctor considers suitable. The final reduction would be to 37.5 mg after coming off venlafaxine 75 mg.

effexor tapering schedule

Generally, doctors will ask if there are any side effects of coming off Effexor and adjust the dosage accordingly. For this reason, some people might take just a few weeks getting off the venlafaxine, whereas others might take longer to do so. Professional doctors are knowledgeable about how to taper off Effexor. Patients should, therefore, consult the doctors before undertaking this process without proper medical knowledge. Without this knowledge, there is a risk of causing significant harm to health.

Switching From Venlafaxine To Other Antidepressants

Occasionally, some situations require switching from one antidepressant to another. It could be that the initial drug did not work well, and the doctor wants to try the patient on another one. Other times, the initial drug might have serious side effects compared to the second one. Nevertheless, there comes a time when it is necessary to change from one antidepressant to another. It is, therefore, possible to switch from venlafaxine to another antidepressant medication.

A moderate switch entails weaning off the patient from the first antidepressant and then allowing a washout period of 2 to 4 days. The new antidepressant is then started at a low dosage. These two modes of switching are advantageous because they reduce the risk of drug interactions.

However, there is also a direct switch where one medication is stopped, and the other started the following day. Although it is quick and simple, there is a high risk of drug interactions. It is, therefore, vital that switching between medications is done only under the recommendation and supervision of a doctor.

Switching From Effexor To Cymbalta

Effexor and weight loss go hand in hand. Some patients might prefer to switch to an SNRI antidepressant that doesn’t cause them to lose weight. Cymbalta can, therefore, become an option. However, by opting for duloxetine (Cymbalta), patients can experience fatigue, diarrhea, and constipation.

When switching from Effexor to Cymbalta, the doctor will recommend a moderate switching strategy. This means that venlafaxine will be tapered off and stopped. After a washout period of 2 to 5 days, the patient can start a low dose of duloxetine.

switching effexor to another med

Switching From Effexor To Wellbutrin

Some patients might consider trading venlafaxine for Wellbutrin because, unlike the latter, the former causes sleepiness and sexual problems. To improve their way of life, some people will, therefore, opt for Wellbutrin. However, the switch to bupropion might increase anxiety.

The cross tapering method is used when switching from venlafaxine to Wellbutrin, also known as bupropion. In this method, the doctor gradually reduces the dose of venlafaxine while simultaneously gradually increasing the dose of bupropion. This kind of switching is possible because there are few side effects of Wellbutrin and Effexor interactions.

Switching From Effexor To Prozac

Patients usually opt to switch to Prozac as a way to sidestep the symptoms of withdrawal from venlafaxine. They switch to Prozac and then taper it off as well – a process known as Effexor-Prozac bridge. Per Keks et al., the switching to Prozac involves weaning off the venlafaxine. Doctors then immediately prescribe 10 mg of fluoxetine, which washes out of the body during the following week.

Switching From Effexor To Zoloft

The plan for how to wean off venlafaxine and switch to Zoloft usually takes the more moderate strategy. This strategy entails tapering the dosage of venlafaxine and stopping for 2 to 5 days before embarking on a low dosage of sertraline (Zoloft). Patients with post-traumatic stress disorder (PTSD) and obsessive-compulsive disorder (OCD) can opt for sertraline if Effexor isn’t working.

Switching From Effexor To Lexapro

If a patient presents with more anxiety symptoms than depression, a doctor might choose to switch from venlafaxine to Lexapro. The switching strategy from venlafaxine to Lexapro is similar to that when switching to Zoloft. This is because these two drugs are both selective serotonin reuptake inhibitors (SSRI). Switching, therefore, requires the patient to taper off from the venlafaxine over 4 weeks and stay clean for 2 to 5 days. The patient then starts the escitalopram at a lower dose than the usual effective recommended dose.

stopping effexor naturally

How To Get Off Effexor Naturally

Some people look for natural ways how to stop taking venlafaxine without switching to other medications. On some online forums, people swear by the natural products that have helped them when coming off prescribed venlafaxine or Effexor abuse. Some of these natural products have the ability to treat depression. If a patient is getting off Effexor, it would make sense to use the natural products to keep the depression at bay.

These products and substances include:

  • extract from the Rhodiola plant, which has been shown to have some mild to moderate antidepressant potency.
  • extract from St. John’s Wort is comparable to selective serotonin uptake inhibitors when it comes to treating depression.
  • amino acids like L-Tyrosine.
  • fish oils, which also have some antidepressant properties.

Other healthy ways that assist in stopping the medication include living a healthy lifestyle. This means that patients should stop chasing the venlafaxine hydrochloride high and engage in exercise. Patients should also eat a balanced diet.

How To Stop Taking Effexor Safely

When it comes to stopping Effexor safely, patients need to be under the guidance of a doctor. This is because medical personnel has the right knowledge of how to wean off Effexor.

Going off Effexor cold turkey is not advisable because it leads to some bad side effects. Therefore, patients should use the tapering method that involves weaning off the venlafaxine to switch to another drug or to stop taking any drugs. During this time, patients should desist from Effexor and alcohol consumption because it can compromise the safety of the process of stopping the drug.

Patients should not attempt to stop taking venlafaxine without consulting professional doctors who have experience in substance abuse prevention and treatment, as well as managing discontinuation syndrome. Because stopping can be a complicated process, some patients will need to check into a drug rehabilitation facility to get effective care.

Page Sources

  1. Bullock C & Bernstein CA. Discontinuation syndrome and antidepressants. Harvard Health Publishing. 2019. https://www.health.harvard.edu/blog/discontinuation-syndrome-and-antidepressants-2019040416361.
  2. How to taper off your antidepressant. Harvard Health Publishing. 2018. https://www.health.harvard.edu/diseases-and-conditions/how-to-taper-off-your-antidepressant.
  3. Burhani MD, Rasenick MM. Fish oil and depression: The skinny on fats. Journal of Integrative Neuroscience. 2017; 16(s1): S115–S124. doi:10.3233/JIN-170072. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087692/.
  4. Ng QX, Venkatanarayanan N, Ho CY. Clinical use of Hypericum perforatum (St John's wort) in depression: A meta-analysis. Journal of Affective Disorders. 2017; 210: 211-221. doi: 10.1016/j.jad.2016.12.048. https://www.ncbi.nlm.nih.gov/pubmed/28064110
  5. Darbinyan V, Aslanyan G, Amroyan E, Gabrielyan E, Malmström C, Panossian A. Clinical trial of Rhodiola rosea L. extract SHR-5 in the treatment of mild to moderate depression. Nordic Journal of Psychiatry. 2007; 61(5): 343-8. https://www.ncbi.nlm.nih.gov/pubmed/17990195.
  6. Keks N, Hope J, Keogh S. Switching and stopping antidepressants. Australian Prescriber. 2016; 39(3): 76–83. doi:10.18773/austprescr.2016.039. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919171/.

Published on: November 29th, 2019

Updated on: December 19th, 2019

About Author

Nena Messina, Ph.D.

Nena Messina is a specialist in drug-related domestic violence. She devoted her life to the study of the connection between crime, mental health, and substance abuse. Apart from her work as management at addiction center, Nena regularly takes part in the educational program as a lecturer.


Leave a comment

  • Amanda
    I’m on the lowest dose of 47.5mg efexor-xr and want to come off it. What is the best way to do this??