Seroquel Half-Life: How Long Does Seroquel Stay In The System?

Last Updated: February 19, 2020

Seroquel is a drug often prescribed to patients with schizophrenia. The drug is sometimes used for other mental conditions too, including bipolar disorder, for example. Individuals who take the medication may be at risk of developing abusive behavior. Understanding how Seroquel metabolism works is essential for people who want to stop using quetiapine. Long-term use of Seroquel medicine can come with adverse effects. The chemicals in the drug may also remain in the body for some time. A view on questions like what the half-life of Seroquel is should be answered. By understanding the half-life Seroquel has, a person is able to know when the chemicals will be out of their body.

Seroquel Half-Life

When a person stops using quetiapine, they need to realize that the active chemicals found in the medicine will not be expelled from their system immediately. It can take a while for Seroquel metabolites to be removed from the body effectively. Recognizing the half-life of Seroquel XR can help a person to understand when 50% of the active chemicals will be removed from their body. At this point, some tests for the drug may yield a negative result.
Quetiapine MOA is relatively short-lived. The drug is metabolized in the body, and the active chemical goes to work within the first hour after the person taking medicine. It takes between one and two hours for Seroquel to reach a peak concentration in a patient’s body.
When a person asks what Seroquel half-life is, they should note that about half of the active chemical will be removed from their body within the first six-seven hours following the last administration of quetiapine.
Observing the half-life of Seroquel, people should note that this only refers to half of the drug that was administered. Following this six-seven-hour period, there are still some traces of the active chemicals in the drug circulating in the patient’s body.

Hands and heart rate close up.

Variables That Influence How Long Seroquel Stays In The System

Many people may find that the chemicals in this drug are expelled from their body within 48 hours after the last administration. This does not refer to the Quetiapine half-life, but rather to the body’s ability to get rid of all traces linked to the drug. The specific time varies from one person to the next, however. The classification of Seroquel means there are some factors that may affect how the body metabolizes the drug.
A few factors should be considered when asking how long does Seroquel last in the body. Take a closer look at the important factors that may affect the period during which the drug will still be present in a person’s body:


One of the most critical factors is age. Older people have reduced hepatic blood flow. This can alter the way that Seroquel is metabolized. It may also affect how long the medicine will remain present in a person’s system. The poor metabolism in the elderly further contributes to an extended half-life of the medicine.


A person’s weight also presents as a factor in determining the answer to a question like what the half-life of Seroquel is, as well as how long the medicine stays in the system. A person with a higher body weight may find that their body takes longer to metabolize and dispose of the active chemicals in this drug.


Food intake also seems to play a role in the period it takes the body to remove all traces of Seroquel. In addition to food, hydration also seems to have a role to play. Poor hydration affects urinary flow, which may cause the drug to circulate in the body for a longer period of time.

Hepatic Impairment

A person with hepatic impairment may also find that Seroquel remains in their system for longer. When a person has a liver problem, a high dose of this drug can cause poor metabolism of the chemicals. This extends the half-life and time it takes the body to clear the chemicals from the system too.

Man with hepatic impairment.


The specific dosage that a person takes also affects how long it will take for the body to get rid of the chemicals. Quetiapine 25mg dose will certainly be removed from the body significantly faster compared to a higher dose, such as 200mg of the medicine, for example.

Duration Of Administration

Another factor that comes into play when looking at a question like whether Seroquel will show up on a drug test is the duration during which the medicine has been taken. A person who had been taking Seroquel for a longer period will find that it takes their body longer to get rid of the chemicals.

Drug Interactions

When more than a single drug is taken at the same time, then interactions can occur. Sometimes, these interactions cause the body a delay in how long it will take to metabolize and expose the chemicals. When quetiapine is taken with other drugs, there may sometimes be a delay in how long it takes the body to get rid of the chemicals.

Seroquel False Positive

Many people want to know if they should be concerned regarding a Seroquel drug test. There is a common concern about a Seroquel drug test false positive result too.
When asking does Seroquel show up on a drug test, a person does need to understand that it depends on how quickly their body gets rid of the medicine. It is also important for the person to consider when they last took quetiapine.

Laboratory test list and stethoscope.

Seroquel Drug Tests

How long do the effects of Seroquel last? When a person asks how long the drug stays in the system, it is essential to focus on what samples will be used for testing purposes. The chemical accumulates in various areas of the person’s body. Quetiapine half-life refers to how long it takes for only half of the chemicals to leave the body. Following this period, the person will still find that some of the drug’s active compounds that are present in their body.

How Long Does Seroquel Stay In One’s Urine And Blood?

It is generally thought that Seroquel will leave the system completely within 48 hours. In the study about the detection of quetiapine in the blood, urine, and hair samples, the initial test was done in 43 hours following the administration of the drug. The researchers describe that traces of Seroquel were found in both blood and urine samples.
This was within the 48 hours during which the drug is metabolized by the body. This period already exceeded the half-life, which explained the low concentration of the chemicals detected in urine and blood samples.

How Long Does Seroquel Stay In One’s Hair Follicle?

At a six-month period following the administration of the drug, traces of its active chemicals were still detectable in the patient’s hair samples. Thus, Seroquel does seem to remain active in hair follicles and in the hair itself for a much more significant period of time compared to urine and blood samples.

Tips To Clear Seroquel From The System

There are some ways to clear Seroquel from the patient’s body faster. It is crucial that the patient initially considers factors that affect the metabolism of quetiapine in their body. The person should also have a thorough understanding of Quetiapine warnings and consider their dosage – high doses lead to more serious adverse effects and causes the drug to remain active for longer.
Doctor presenting a personalized diet plan.
There are a few ways to clear Seroquel from the system faster. Here are a few tips that may be useful:

  • Stop using Seroquel completely, but not abruptly. Consult with a doctor about the tapering process.
  • The use of a CYP3A4 induction drug may be helpful too.
  • Daily exercise is important to get rid of the chemicals faster.
  • Proper hydration is also a critical factor, as a large percentage of quetiapine’s components will be expelled through urination.

While one is tapering off the drug, Quetiapine withdrawal may appear. It is advisable to undergo medical detoxification to manage them faster and more effectively. If one feels unable to function daily without this drug, they may be addicted to Seroquel. This condition may lead to irreversible health damage and needs to be observed by addiction treatment experts. Help from a rehabilitation center should be admitted to begin a healthy and addiction-free life.

Page Sources

  1. Johansen SS, Detection of the antipsychotic drug quetiapine in the blood, urine and hair samples of the victim of a drug-facilitated sexual assault,
  2. U.S. Food and Drug Administration, SEROQUEL (quetiapine fumarate) TABLETS,,016_seroquel_lbl.pdf
  3. DeVane CL, Nemeroff CB., Clinical pharmacokinetics of quetiapine: an atypical antipsychotic,

Published on: February 19th, 2020

Updated on: February 19th, 2020


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