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Seroquel Dosage: How Much Quetiapine Doses Be Taken Daily?

Quetiapine pills and capsules

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Quetiapine, sold under the brand name Seroquel, is a Multi-Acting Receptor-Targeted Antipsychotic (MARTA) that is used in the treatment of a number of mental disorders, including (but not limited to) schizophrenia in patients aged 13 and above, and bipolar disorder in patients aged 10 and above. Quetiapine dosage is available in different forms and strengths, under different generic or brand names.
This variation makes it even more important for any potential user to confirm knowledge of the appropriate dosage information and recommended maximum Quetiapine dose per medical condition before using the drug. This will not only ensure that the drug is used safely, but it will reduce the chances of an enhanced nature of side effects resulting from a Quetiapine overdose.
For instance, the recommended Seroquel dose for depression will be different from the one for anxiety.

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Table Of Contents:

Seroquel Dosage Forms And Strengths

The drug is available as the regular Seroquel IR (immediate-release) and Seroquel XR (extended-release). The major difference between these two is that the XR variant is used in significantly higher doses as a primary antipsychotic medication, while the regular Seroquel is more commonly used in lower doses as an add-on for another drug, possibly for its sedative or anxiolytic effects. Despite this difference, the mechanism of action for Quetiapine variants is the same.
Pill container on a gray background.
The regular Seroquel drug is available from 25mg doses all the way up to 400mg. This dosage strength list includes Seroquel 50mg, 100mg, 200mg, and 300mg tablets for oral administration. On the other hand, Seroquel XR’s dosage strengths list includes 50mg, 150mg, 200mg, 300mg, and 400mg tablets – also for oral administration. After administration, the half-life of Quetiapine generally falls within six to seven hours.
For easy identification, the tablets from 25mg up to Seroquel 200mg are all round in shape. The 50mg and 200mg tablets are white in color, the 25mg tab is peach, and the 100mg tab is yellow.  Seroquel 300mg and 400mg tablets are both capsule-shaped. The former is white in color while the latter is yellow.

Seroquel Doses For Depression, Bipolar And Other Conditions

As suggested earlier, the appropriate dosing schedules for Seroquel varies according to factors such as the specific disorder being treated, and other health conditions that are particular to each patient and could interfere with treatment. For instance, one of the possible side effects of the drug is Quetiapine weight gain, so users that already struggle with weight-related health conditions may require custom schedules from the doctor.

For the Quetiapine dosing schedule discussed in this section, the information is divided into sub-sections according to the age group of the patient being treated (adults, geriatric adults, and adolescents).

Seroquel Dosage For Adults

The recommended dosing schedule for regular adults using Seroquel is as follows:

ConditionDrug VariantInitial DoseFrequencyVarianceMaximum daily dose
Major depressionSeroquel XR50mgOnce per twenty-four hours in the evening for the first two days150mg once per twenty-four hours on day 3300mg
Bipolar disorder, including mania and bipolar depressionSeroquel IR50mgTwice per first twenty-four hoursIf required, increase by 100mg per day in two doses until the daily dosage hits 400mg on day 4.
If needed, further increase to 800mg per twenty-four hours by day 6 at a daily increment rate of 200mg per twenty-four hours  in divided doses.
800mg (in two divided doses)
Bipolar disorder, including mania and bipolar depressionSeroquel XR300mgOnce in the evening per first twenty-four hours600mg once in the evening on day 2.
If needed, adjust the dose on day 3 based on tolerability and response.
800mg
Bipolar depression during depressive episodes of bipolar I or bipolar II disorderSeroquel IR/XR50mgOnce at bedtime on day 1Increase the dose to 100mg at bedtime on day 2, 200mg on day 3 and 300mg on day 4.300mg
SchizophreniaSeroquel IR25mgTwice daily per first twenty-four hoursIncrease by 25mg – 50mg from day 2 until a target dose of 300mg-400mg per twenty-four hours is reached on day 4. This should be administered in divided doses about two to three times per day.800mg
SchizophreniaSeroquel XR300mgOnce a day in the eveningIncrease the dose at a maximum daily rate of 300mg per twenty-four hours with one-day intervals until a range of 400mg-800mg once a day is achieved. The specific dose should be decided based on tolerability and response.800mg

Seroquel Dosage For Geriatric Adults

The recommended dosing schedule for Geriatric adults using Seroquel is as follows:

ConditionDrug VariantInitial DoseFrequencyVarianceMaximum daily dose
Major depressionSeroquel XR50mgOnce a day on day 1 and 2If required, the dosage may be increased by 50mg per twenty-four hours depending on tolerability and response of the patient300mg
Bipolar disorder, including mania and bipolar depressionSeroquel IR25mgTwice dailyIf required, the dosage may be increased by 50mg per twenty-four hours depending on tolerability and response of the patient.800mg  in two divided doses
Bipolar disorder, including mania and bipolar depressionSeroquel XR50mgOnce per twenty-four hours in the eveningIf required, the dosage may be increased by 50mg per twenty-four hours depending on tolerability and response of the patient.800mg
SchizophreniaSeroquel IR25mgTwice per twenty-four hoursIf required, increase doses slowly based on individual tolerability and response.800mg
SchizophreniaSeroquel XR50mgOnce a dayIf required, the dosage may be increased by 50mg/day depending on tolerability and response of the patient.800mg

Seroquel Dosage For Adolescents

The recommended Seroquel dosing for adolescents using is as follows:

AgeConditionDrug VariantInitial DoseFrequencyVarianceMaximum daily dose
10 years and olderBipolar disorder, including mania and bipolar depressionSeroquel IRSeroquel 25mgTwice a day per first twenty-four hoursIncrease the dose to 50 mg twice a day on Day 2, 100 mg twice a day on Day 3, 150 mg twice a day on Day 4, and 200 mg twice a day on Day 5.
After day 5, any adjustments should fall within the recommended dose of 400mg-600mg/day based on tolerability and response.
Seroquel 600mg
10 years and olderBipolar disorder, including mania and bipolar depressionSeroquel XR50mgOnce in the evening per first twenty-four hoursIncrease the dose to 100 mg once in the evening on Day 2, 200 mg once in the evening on Day 3, 300 mg once on Day 4, and 400 mg once on Day 5.
After day 5, any adjustments should fall within the recommended dose of 400mg-600mg/day based on tolerability and response
600mg
13 years and olderSchizophreniaSeroquel IR25mgTwice daily per first twenty-four hoursIncrease the dose to Quetiapine 50 mg twice daily on Day 2, 100 mg twice daily on Day 3, 150 mg twice daily on Day 4, and 200 mg twice daily on Day 5.
After day 5, any adjustments should fall within the recommended dose of 400mg-800mg/day based on tolerability and response
800mg in three divided doses
13 years and olderSchizophreniaSeroquel XR50mgOnce a day per first twenty-four hoursIncrease the dose to 100 mg/day on Day 2, 200 mg/day on Day 3, 300 mg/day on Day 4, and 400 mg once a day from Day 5800mg

Re-initiating Quetiapine Treatment

An important point to note when re-initiating Quetiapine treatment for patients who have discontinued use of the medication is that titration is not always required – it all depends on the length of time that has passed since the last dose. Generally, if treatment was discontinued for less than a week, then it can be picked up from the last titration point. If the treatment has been discontinued for more than a week, it is recommended that the patient should restart from the initial recommended Quetiapine dose.
Pill box with seroquel and medication bottle

Quetiapine Safety Instructions

Storage and Handling

To keep the drug in the best conditions possible. It is recommended that Seroquel should be stored at room temperature, away from heat and moisture.

How To Take Seroquel Safely?

Here are some tips for using Seroquel as safely as possible:

  • Never take a larger amount than is recommended by the doctor
  • For patients with diabetes, check blood sugar levels constantly while using Quetiapine as it may lead to higher levels
  • Do not chew, crush or break an extended-release tablet. It must be swallowed at once.
  • Avoid consuming alcohol during the treatment course.
  • Do not drive or operate heavy machinery until the effects of the drug become familiar
  • Stopping Seroquel dosage should not be done cold turkey. The best way to stop dosage is to wean gradually off it.
  • Avoid getting overheated and always stay hydrated
  • To avoid/reduce dizziness, what is a part of Quetiapine side effects, do not get up too fast from sitting or lying positions
  • If a dose is missed, it should be used immediately unless it is nearly time for the next dose.

Always keep in mind that addiction to Serquel can occur, even unintendedly, and signs of this condition are the signal to set up the appointment with an addiction treatment specialist. They will advise a tailored rehabilitation program that will help to return back to a healthy life.

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View Sources
  1. The United States Food and Drug Administration, Seroquel Medication Guide, 2013, https://www.fda.gov/files/drugs/published/Seroquel-Medication-Guide.pdf
  2. Masi G, Milone A, Veltri S, Iuliano R, Pfanner C, Pisano S, Use of quetiapine in children and adolescents, 2015, https://www.ncbi.nlm.nih.gov/pubmed/25686575
  3. Jasdave S. Maan; Abdolreza Saadabadi, Quetiapine, 2019, https://www.ncbi.nlm.nih.gov/books/NBK459145/

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