Quetiapine, sold under the brand name Seroquel, is a Multi-Acting Receptor-Targeted Antipsychotic (MARTA) that is used in the treatment of a number of mental disorders, including (but not limited to) schizophrenia in patients aged 13 and above, and bipolar disorder in patients aged 10 and above. Quetiapine dosage is available in different forms and strengths, under different generic or brand names.
This variation makes it even more important for any potential user to confirm knowledge of the appropriate dosage information and recommended maximum Quetiapine dose per medical condition before using the drug. This will not only ensure that the drug is used safely, but it will reduce the chances of an enhanced nature of side effects resulting from a Quetiapine overdose.
For instance, the recommended Seroquel dose for depression will be different from the one for anxiety.
Table Of Contents:
Seroquel Dosage Forms And Strengths
The drug is available as the regular Seroquel IR (immediate-release) and Seroquel XR (extended-release). The major difference between these two is that the XR variant is used in significantly higher doses as a primary antipsychotic medication, while the regular Seroquel is more commonly used in lower doses as an add-on for another drug, possibly for its sedative or anxiolytic effects. Despite this difference, the mechanism of action for Quetiapine variants is the same.
The regular Seroquel drug is available from 25mg doses all the way up to 400mg. This dosage strength list includes Seroquel 50mg, 100mg, 200mg, and 300mg tablets for oral administration. On the other hand, Seroquel XR’s dosage strengths list includes 50mg, 150mg, 200mg, 300mg, and 400mg tablets – also for oral administration. After administration, the half-life of Quetiapine generally falls within six to seven hours.
For easy identification, the tablets from 25mg up to Seroquel 200mg are all round in shape. The 50mg and 200mg tablets are white in color, the 25mg tab is peach, and the 100mg tab is yellow. Seroquel 300mg and 400mg tablets are both capsule-shaped. The former is white in color while the latter is yellow.
Seroquel Doses For Depression, Bipolar And Other Conditions
As suggested earlier, the appropriate dosing schedules for Seroquel varies according to factors such as the specific disorder being treated, and other health conditions that are particular to each patient and could interfere with treatment. For instance, one of the possible side effects of the drug is Quetiapine weight gain, so users that already struggle with weight-related health conditions may require custom schedules from the doctor.
For the Quetiapine dosing schedule discussed in this section, the information is divided into sub-sections according to the age group of the patient being treated (adults, geriatric adults, and adolescents).
Seroquel Dosage For Adults
The recommended dosing schedule for regular adults using Seroquel is as follows:
|Condition||Drug Variant||Initial Dose||Frequency||Variance||Maximum daily dose|
|Major depression||Seroquel XR||50mg||Once per twenty-four hours in the evening for the first two days||150mg once per twenty-four hours on day 3||300mg|
|Bipolar disorder, including mania and bipolar depression||Seroquel IR||50mg||Twice per first twenty-four hours||If required, increase by 100mg per day in two doses until the daily dosage hits 400mg on day 4.
If needed, further increase to 800mg per twenty-four hours by day 6 at a daily increment rate of 200mg per twenty-four hours in divided doses.
|800mg (in two divided doses)|
|Bipolar disorder, including mania and bipolar depression||Seroquel XR||300mg||Once in the evening per first twenty-four hours||600mg once in the evening on day 2.
If needed, adjust the dose on day 3 based on tolerability and response.
|Bipolar depression during depressive episodes of bipolar I or bipolar II disorder||Seroquel IR/XR||50mg||Once at bedtime on day 1||Increase the dose to 100mg at bedtime on day 2, 200mg on day 3 and 300mg on day 4.||300mg|
|Schizophrenia||Seroquel IR||25mg||Twice daily per first twenty-four hours||Increase by 25mg – 50mg from day 2 until a target dose of 300mg-400mg per twenty-four hours is reached on day 4. This should be administered in divided doses about two to three times per day.||800mg|
|Schizophrenia||Seroquel XR||300mg||Once a day in the evening||Increase the dose at a maximum daily rate of 300mg per twenty-four hours with one-day intervals until a range of 400mg-800mg once a day is achieved. The specific dose should be decided based on tolerability and response.||800mg|
Seroquel Dosage For Geriatric Adults
The recommended dosing schedule for Geriatric adults using Seroquel is as follows:
|Condition||Drug Variant||Initial Dose||Frequency||Variance||Maximum daily dose|
|Major depression||Seroquel XR||50mg||Once a day on day 1 and 2||If required, the dosage may be increased by 50mg per twenty-four hours depending on tolerability and response of the patient||300mg|
|Bipolar disorder, including mania and bipolar depression||Seroquel IR||25mg||Twice daily||If required, the dosage may be increased by 50mg per twenty-four hours depending on tolerability and response of the patient.||800mg in two divided doses|
|Bipolar disorder, including mania and bipolar depression||Seroquel XR||50mg||Once per twenty-four hours in the evening||If required, the dosage may be increased by 50mg per twenty-four hours depending on tolerability and response of the patient.||800mg|
|Schizophrenia||Seroquel IR||25mg||Twice per twenty-four hours||If required, increase doses slowly based on individual tolerability and response.||800mg|
|Schizophrenia||Seroquel XR||50mg||Once a day||If required, the dosage may be increased by 50mg/day depending on tolerability and response of the patient.||800mg|
Seroquel Dosage For Adolescents
The recommended Seroquel dosing for adolescents using is as follows:
|Age||Condition||Drug Variant||Initial Dose||Frequency||Variance||Maximum daily dose|
|10 years and older||Bipolar disorder, including mania and bipolar depression||Seroquel IR||Seroquel 25mg||Twice a day per first twenty-four hours||Increase the dose to 50 mg twice a day on Day 2, 100 mg twice a day on Day 3, 150 mg twice a day on Day 4, and 200 mg twice a day on Day 5.
After day 5, any adjustments should fall within the recommended dose of 400mg-600mg/day based on tolerability and response.
|10 years and older||Bipolar disorder, including mania and bipolar depression||Seroquel XR||50mg||Once in the evening per first twenty-four hours||Increase the dose to 100 mg once in the evening on Day 2, 200 mg once in the evening on Day 3, 300 mg once on Day 4, and 400 mg once on Day 5.
After day 5, any adjustments should fall within the recommended dose of 400mg-600mg/day based on tolerability and response
|13 years and older||Schizophrenia||Seroquel IR||25mg||Twice daily per first twenty-four hours||Increase the dose to Quetiapine 50 mg twice daily on Day 2, 100 mg twice daily on Day 3, 150 mg twice daily on Day 4, and 200 mg twice daily on Day 5.
After day 5, any adjustments should fall within the recommended dose of 400mg-800mg/day based on tolerability and response
|800mg in three divided doses|
|13 years and older||Schizophrenia||Seroquel XR||50mg||Once a day per first twenty-four hours||Increase the dose to 100 mg/day on Day 2, 200 mg/day on Day 3, 300 mg/day on Day 4, and 400 mg once a day from Day 5||800mg|
Re-initiating Quetiapine Treatment
An important point to note when re-initiating Quetiapine treatment for patients who have discontinued use of the medication is that titration is not always required – it all depends on the length of time that has passed since the last dose. Generally, if treatment was discontinued for less than a week, then it can be picked up from the last titration point. If the treatment has been discontinued for more than a week, it is recommended that the patient should restart from the initial recommended Quetiapine dose.
Quetiapine Safety Instructions
Storage and Handling
To keep the drug in the best conditions possible. It is recommended that Seroquel should be stored at room temperature, away from heat and moisture.
How To Take Seroquel Safely?
Here are some tips for using Seroquel as safely as possible:
- Never take a larger amount than is recommended by the doctor
- For patients with diabetes, check blood sugar levels constantly while using Quetiapine as it may lead to higher levels
- Do not chew, crush or break an extended-release tablet. It must be swallowed at once.
- Avoid consuming alcohol during the treatment course.
- Do not drive or operate heavy machinery until the effects of the drug become familiar
- Stopping Seroquel dosage should not be done cold turkey. The best way to stop dosage is to wean gradually off it.
- Avoid getting overheated and always stay hydrated
- To avoid/reduce dizziness, what is a part of Quetiapine side effects, do not get up too fast from sitting or lying positions
- If a dose is missed, it should be used immediately unless it is nearly time for the next dose.
Always keep in mind that addiction to Serquel can occur, even unintendedly, and signs of this condition are the signal to set up the appointment with an addiction treatment specialist. They will advise a tailored rehabilitation program that will help to return back to a healthy life.
- The United States Food and Drug Administration, Seroquel Medication Guide, 2013, https://www.fda.gov/files/drugs/published/Seroquel-Medication-Guide.pdf
- Masi G, Milone A, Veltri S, Iuliano R, Pfanner C, Pisano S, Use of quetiapine in children and adolescents, 2015, https://www.ncbi.nlm.nih.gov/pubmed/25686575
- Jasdave S. Maan; Abdolreza Saadabadi, Quetiapine, 2019, https://www.ncbi.nlm.nih.gov/books/NBK459145/