PCP VS Ketamine, LSD, Acid, Meth, And DXM
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Also known as Angel dust, Phencyclidine (PCP) is a powerful hallucinogenic drug with dissociative anesthetic properties that produce a wide variety of physical and behavioral effects which has a high tendency for abuse and dependence. PCP alternative drugs function and exert the same or similar properties to that of phencyclidine. These PCP alternative drugs can cause users feel out of control or disconnected from their body and environment. This article aims to give detailed insight into various PCP analogs.
Table of Contents
PCP Derivative Analogs
PCP analogs are chemical structures further derived from angel dust as a result of alterations in their chemical structure:
- Eticyclidine (PCE). It is more active than angel dust.
- Rolicyclidine(PCPy) is slightly less potent than Zombie weed, a well-used PCP slang among youths. Making PCP is a synthetic process with the use of some chemicals as an intermediary.
- Thienyl Cyclohexyl Piperidine(TCP), on the other hand, has more or less the same activity as angel dust.
PCP vs. Ketamine
Phencyclidine and ketamine are both dissociative hallucinogens. Just like Ketamine, Phencyclidine mechanism of action is to interfere with the brain’s chemical glutamate, thereby allowing users to get relieved from pains, gain access to old-time memories and events.
- They are both hallucinogenic drugs with dissociative anesthetic properties.
- PCP and ketamine both block the action of the neurotransmitter glutamate at one of its receptors.
- PCP and ketamine both cause a prolonged state resembling paranoid schizophrenia.
- PCP and ketamine are both structurally related.
- Ketamine has a lesser potency and shorter duration of action (less than half an hour) than Phencyclidine.
- Synthesis of ketamine is difficult compared to Phencyclidine.
- Ketamine has a lower incidence of adverse effects and generally produces CNS depression than Phencyclidine.
Just like Ketamine, Phencyclidine has short term effects as well as long term effects depending on the dose and route of administration. The short term side effects include numbness, a sense of well-being and euphoria, slurred speech, loss of motor coordination, misconception of abilities odd, erratic, or unexpected behavior.
At higher doses, the side effects include hallucinations, impaired memory, severe depression with suicidal thoughts, extreme weight loss, delusional thinking, agitation, catatonic rigidity, disorientation, and occasionally, malignant hyperthermia, while the side effects of ketamine include blurred vision, confusion, hallucinations, unusual thoughts, amnesia, slow heartbeat.
Which is more potent?
Ketamine is more potent than Phencyclidine; this is because Ketamine produces more significant CNS depression than Phencyclidine. Phencyclidine is more dangerous than ketamine due to its high rate of addiction.
PCP vs. LSD
LSD, also known as lysergic acid diethylamide, is one of the powerful psychoactive drugs which acts as both an agonist and antagonist. LSD is known as a classic hallucinogen, while Phencyclidine is classified as a dissociative drug.
- PCP and LSD drugs are both hallucinogens.
- PCP and LSD both block the action of the neurotransmitter glutamate at one of its receptors.
- PCP and LSD are both structurally related.
- PCP and LSD are both human-made chemicals.
- LSD belongs to a class of hallucinogens called classic hallucinogens while Phencyclidine belongs to a class called dissociative hallucinogens.
- LSD has a lesser potency and shorter duration of action than Phencyclidine.
Just like in the case of Phencyclidine, users who consume LSD are likely to experience similar symptoms like catatonic rigidity, vomiting, disorientation, depression, distortion of body image, depersonalization, disorders of thought and time sense, synesthesia and anxiety.
Which is more potent?
LSD is more potent than LSD due to its swift behavioral effects that can be noticeable after doses as low as 20 micrograms. Phencyclidine is more dangerous than LSD due to its high addiction rate. Phencyclidine also contains more metabolites than LSD.
DXM vs. PCP
DXM is a cough suppressant which is found in cough syrups which acts as a dissociative anesthetic like ketamine or Phencyclidine. DXM is also known as dextromethorphan.
- They are both have dissociative anesthetic properties.
- They both block the action of the neurotransmitter glutamate at one of its receptors.
- Phencyclidine and DXM are both structurally related.
- The side effects of DXM is milder when compared to Phencyclidine’s side effects.
- DXM and Phencyclidine bind different receptors. DXM effects Opioid, while Phencyclidine is a D2 receptor agonist and Dopamine reuptake inhibitor
Since DXM and Phencyclidine both act on the same pathway in exerting some properties, their side effects are somewhat similar. Some of the common DXM and angel dust side effects include disorientation, incoordination, nystagmus, hypersalivation, dizziness, and respiratory depression.
Which is more potent?
Phencyclidine is more potent than DXM due to its serious adverse effects. Phencyclidine is also more dangerous than DXM, due to its high dependence rate, which can lead to death.
PCP vs. Meth
Methamphetamine is a potent stimulant that affects the nervous system. Just like Phencyclidine, Meth is available in liquid, tablet, or powder forms. It can be snorted with the nose, injected intravenously or ingested orally. Both Meth and Phencyclidine can both be smoked as a joint. PCP wet is a term mostly used when liquefied phencyclidine is sprinkled on cigarettes or marijuana leaves. At this stage, a permanent marker PCP smell can be observed.
- They both act on the central nervous system.
- Meth and Phencyclidine have a reliably enhanced locomotion and produced stereotypy at high doses.
- Methamphetamine enhances dopamine and serotonin transmission in the brain, whereas Phencyclidine disrupts glutamate transmission.
- The effects of Meth on locomotion last until three days, but no more than seven days after injection. Phencyclidine, however, lasts around 11 days for
Meth is an amphetamine anorexigenic agent and also a CNS stimulant. Meth has a high potential for abuse; hence, it must not be used for an extended period. With Meth and angel dust, both acting as a dopamine reuptake inhibitor, patients are likely to experience the following side effects which include catatonic rigidity, disorientation, incoordination insomnia, night terrors, nervousness, and restlessness.
Which is more potent?
Meth is more potent than angel dust due to its swift behavioral effects in the brain. It takes about 9 minutes after use. Also, Meth’s clearance from the brain is slow. Angel dust is more dangerous than meth, due to its high dependence rate, which can lead to death.
Looking For PCP Alternative
People look for Phencyclidine alternatives because some of them are less dangerous, less potent, and have fewer side effects when compared to Phencyclidine. Even though Phencyclidine alternative drugs like LSD, DXM, and methoxetamine, which is pcp drug class have similar chemical structures as angel dust, majority of them are less addictive, hence, the high demand for them. Nonetheless, users of angel dust alternative drugs also risk some significant side effects if the excess dose is consumed.
Avoid Abuse Of Any Drugs
Angel dust alternate drugs and PCP itself are hallucinogens, which can be addictive. Hence it should be taken under a doctor’s supervision. Excess intake of PCP alternative drugs can lead to severe health complications. Additionally, Phencyclidine overdose leads to death as a result of respiratory depression.
- Joanna S. Fowler, Nora D. Volkow et al. Fast Uptake and Long-Lasting Binding of Methamphetamine in the Human Brain. Neuroimage. 2008 Dec; 43(4): 756–763. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2606665/
- D Lodge, M S Mercier. Ketamine and phencyclidine: the good, the bad and the unexpected. Br J Pharmacol. 2015 Sep; 172(17): 4254–4276. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556466/
- Torsten Passie, John H. Halpern, Dirk O. Stichtenoth, Hinderk M. Emrich, Annelie Hintzen. The Pharmacology of Lysergic Acid Diethylamide: A Review. CNS Neurosci Ther. 2008 Winter; 14(4): 295–314. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494066/
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