It is crucial to keep yourself and your loved ones safe during the COVID-19 outbreak. Yet addiction may pose even a higher danger than the virus.

Learn about recovery during the pandemic:

Nicotine Overdose: Symptoms, Treatment, And Risk Of Death

nicotine overdose

Important InformationThis information is for educational purposes only. We never invite or suggest the use, production or purchase of any these substances. Addiction Resource and it’s employees, officers, managers, agents, authors, editors, producers, and contributors shall have no direct or indirect liability, obligation, or responsibility to any person or entity for any loss, damage, or adverse consequences alleged to have happened as a consequence of material on this website. See full text of disclaimer.

Nicotine overdose occurs when an individual consumes too much of it within a short period of time.
It is a habit-forming chemical which one can find in various tobacco products. They include cigarettes, cigars, electronic cigarettes, tobacco chew or snuff. Smoking reduction/cessation products such as patches, gums, and lozenges also contain it.
Adults are not likely to overdose on it just by smoking. However, there have been reported some cases of overdose in kids who accidentally ate it. Even a small amount can cause lots of problems.

Table of Contents

Factors That Affect The Severity Of Nicotine Overdose

There are two prime factors that determine if an amount of Nicotine will produce toxic effects. They are body weight and its source.
In general, higher the body weight, greater the amount one needs to produce the symptoms of overdose.
Likewise, tobacco products such as e-cigarettes can pose a greater risk. This is because they contain a liquid form of Nicotine. Therefore, it’s more potent and more likely to cause harm even with a small amount.
Other products such as lozenges and gums are very dangerous. This is because of their inviting appearance. In fact, kids may mistake some of them for candy or chewing gum. As a result, this leaves them vulnerable to dangerous levels in their blood.

Help Line Woman

Hope Without Commitment

Find the best treatment options.
Call our free and confidential helpline

Most private insurances accepted

Marketing fee may apply

Nicotine Overdose Symptoms: A Two-Phase Rollercoaster

Phase I Excitation: It can happen as early as 15 minutes to one hour after ingestion or inhalation. This is when early symptoms of overdose may manifest. If the overdose is mild, the symptoms may last for up to two hours.
However, with heavy poisoning, they may last for more than 24 hours. The symptoms of early Nicotine overdose may include:

  • Abdominal cramp
  • Restlessness or over-excitement
  • Increased salivation
  • Rapid breathing
  • Elevated blood pressure
  • Muscle twitches
  • Mental confusion
  • Racing heartbeat

Phase II Depression: During the next 30 minutes to four hours, the overall body functions slow down. The typical Nicotine overdose symptoms in this phase include:

  • Diarrhea or loose motion
  • Depression
  • Superficial breathing
  • Reduced blood pressure
  • Slowed pulse or heartbeat
  • Weakness
  • Loss of control over muscle movements or reflexes
  • Convulsions
  • Coma

How Nicotine Overdose Affects The Body And Brain

NicotineNicotine possesses mind-altering properties. This is by the virtue of its ability to change the levels of brain chemicals. Being an oil-soluble substance, it reaches the brain rapidly after eating or smoking.
The chemical exerts its effects by mimicking the activities of a brain chemical. Scientists call it acetylcholine (ACh). This is after it reaches the brain. ACh is an important functional component of the nervous system. It has a widespread role in muscle movement, breathing, heartbeat, memory, and learning.
Additionally, it boosts the level of another mood-enhancing brain chemical. They call it dopamine. Having high levels of dopamine in the brain gives the the feelings of pleasure and reward. This is the reason why quitting smoking is such a tough task.
When a person overdoses, the first set of symptoms is mainly excitatory in nature. However, within some hours, the nicotine binding sites in the brain will become full. After this excitation plunges, the symptoms of depression begin to manifest.

How Much Nicotine Does It Take To Overdose?

The dosage a person needs for nicotine overdose is way higher than what is possible to get by smoking or chewing tobacco. Thus, it is quite unlikely that smoking or chewing can turn fatal. This is even when trying to overdo it.
Still, one can consume fatal doses through other sources. They include e-cigarettes, nicotine gums, and lozenges.
An average adult needs to consume at least 50 to 60 mg of nicotine to develop overdose symptoms. This is according to the Centers for Disease Control and Prevention (CDC).
To poison onelself with nicotine, a person would need to smoke at least two packs continuously if a cigarette contains only 1mg of it.
This doesn’t seem possible even for the puproseful attempt. Yet, for the kids, even the nicotine inside a single cigarette may be toxic. Be aware of Nicotine addiction signs to prevent overdose.
In any case, what determines the toxicity is how much nicotine reaches the brain.

Nicotine Overdose Death

Death due to Nicotine overdose is very rare. Sometimes, people ingest pesticides that contain nicotine, according to the cases people report. Almost all the cases of death from nicotine overdose have been from this, including both accidental and intentional poisonings.

Nicotine Overdose Treatment

There is no known antidote to treat nicotine overdose. Available medications help to improve the overdose symptoms and ease the recovery. An immediate treatment produces successful results in almost every case of overdose.
The medications that provide supportive treatment include:

  • Activated charcoal – if the patient is conscious and able to take it by mouth. Also, this treatment is more effective if the time of Nicotine overdose has not gone beyond a few hours. This may help to reduce its absorption inside the digestive tract.
  • Benzo to control seizures
  • Fluid and salt injection to treat low blood pressure
  • Atropine – This is a naturally occurring chemical. It acts against the activities of ACh to treat slowed pulse
  • If breathing is very slow, the doctor may recommend artificial ventilation. It will support natural breathing.
  1. National Institute on Drug Abuse. Cigarettes and Other Tobacco Products. 2018.
  2. Genetic Science Learning Center. How Drugs Can Kill.
Isaak Stotts

About Author

Isaak Stotts, LP

Isaak Stotts is an in-house medical writer in AddictionResource. Isaak learned addiction psychology at Aspen University and got a Master's Degree in Arts in Psychology and Addiction Counseling. After graduation, he became a substance abuse counselor, providing individual, group, and family counseling for those who strive to achieve and maintain sobriety and recovery goals.


Leave a comment