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Getting High On Naproxen – Does Naprosyn Get One High?

Pile Of Blue Pills

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It is almost impossible to experience Naproxen high since Aleve does not bind the opioid receptors in the brain. Nonetheless, Naproxen recreational use can lay host to some devastating side effects. This article helps to define Naproxen and serves as an informational guide for patients to learn about Naproxen’s effects and the possibility of getting high.

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Table of contents

Possibility Of Getting High

Many people are curious to know whether it is possible for someone to experience Naproxen high after consuming. The answer is NO. It is impossible to get high on Naproxen, irrespective of the dosage consumed ― whether Naproxen sodium 220 mg or 550 mg. There is a report about the person who consumed 70-gram Naproxen mixed with alcohol. The patient was said to have profound drowsiness and lethargy. Those were the only symptoms present and it clearly shows how impossible it is to get high on Naproxen. While Aleve shares certain properties with opioid pain medications, their mechanism of action differs entirely. It does not affect the body’s opioid receptors, hence there is no euphoria or high. Instead, Aleve acts by blocking the production of prostaglandin hormones. This action relieves pain for numerous hours.

Getting high on prescription and otc medicines is a dangerous affair. One risks own health and sometimes even life. Intentional and prolonged abuse of prescription and otc medicine significantly diminishes the quality of life and creates additional health issues

Aleve High

Just like Ibuprofen and other nonsteroidal anti-inflammatory drugs(NSAIDs), consuming high doses of Aleve doesn’t result in euphoria or highness. Nonetheless, Naproxen high can be achieved when it is mixed with strong opioid drugs like Fentanyl or Oxymorphone.


It takes about an hour for a Naproxen 375 mg tablet to start acting in the body. The duration depends mostly on the dosage consumed, route of administration and metabolism levels. Usually, the duration of high is between 8 hours (for 250 mg direct release pill) and 15 hours (for 350 and 500 mg extended-release pills). When combined, the concomitant use of Fentanyl and Aleve can result in profound highness that can last up to 24 hours.


Since it is almost impossible to achieve high on Aleve, recreational drug users end up mixing Naprosyn with other drugs like Morphine, Fentanyl, and Tramadol. At this point, the physical euphoria felt is highly intensive. If taken in excess, patients may experience memory loss, disorientation, impaired speech, impaired mental acuity, and more. The use of  Codeine and Aleve may induce an intense high that will result in increased pain threshold. At this stage, it is important to note that while these side effects seem mild and moderate, they can result in death. Ultimately, mixing Naproxen with other drugs in order to achieve mind-altering effects is not safe.

Woman Falling Asleep At The Desk


People who consume Aleve can experience dizziness, blurry vision, lightheadedness, and drowsiness. The aftereffects are almost the same in Naproxen sodium vs Ibuprofen comparison. Listed below are effects of Naproxen

  • Headaches and Migraines
  • Dry mouth
  • Impaired vision
  • Anxiety
  • Excitement
  • Belching
  • Bruising.
  • Feeling of indigestion
  • Itching skin
Aleve has an effect on the central nervous system. It impairs and alters a patient’s mental or physical abilities.

Ways Of Abuse For Naprosyn

Depending on the brand, strength, and condition being treated, the average medical dosages of Naproxen ranges from 300 to 1000 milligrams, however, people tend to double the recommended dose of Naproxen for recreational purposes. it is a dangerous affair as there is a set of Naproxen warnings that one should be familiar with. Written below are some of the ways people abuse Aleve.

Any method of abuse brings own dangers and it is impossible to stay safe from adverse reactions


Can one snort Naproxen? Well, yes, it’s very possible. The process basically involves inhaling a powdered or crushed pill through the nostrils. The absorption is rapid and takes a few minutes to enter one’s bloodstream through the sensitive blood vessels inside the nose. Snorting Aleve is dangerous and can result in damages to the lining of the nasal cavity.

Crushed Pill Near Pill Package


Injecting is another way Aleve may be abused by the individual. Shooting Hydroxyzine lays its own host of problems like:

  • tissue damage
  • contamination (through the shared needles)
  • nosebleeds
  • bleeding gums
  • bleeding from cuts that take a long time to stop
  • heavier than normal menstrual or vaginal bleeding
  • pink or brown urine
  • red or black stools
  • coughing up blood

Staying Safe From Naproxen Abuse

Even though it is almost impossible to use Naproxen to get high, patients expose themselves to devastating health complications upon consuming high doses for a prolonged period of time.

Can one take Tylenol with Naproxen? Yes. The concomitant use of Tylenol with Naprosyn is considered safe. However, patients should ensure they don’t overdose, as it can lead to severe adverse effects of Aleve. As such, it is important to follow the doctor’s prescription. For someone already addicted to Aleve, one of the solutions is to enroll in an inpatient drug rehab center. Rehabilitation centers help to guide patients on how to quit drug abuse and overdose through the set of special drug addiction treatment programs. Patients also receive counseling and advice to prevent relapse.

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  1. Al-Abri, S. A., Anderson, I. B., Pedram, F., Colby, J. M., & Olson, K. R. (2015). Massive naproxen overdose with serial serum levels. Journal of medical toxicology: official journal of the American College of Medical Toxicology, 11(1), 102–105.
  2. Stacher, G., Bauer, P., Schneider, C. et al. Effects of a combination of oral naproxen sodium and codeine on experimentally induced pain. Eur J Clin Pharmacol 21, 485–490 (1982).


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