Methadone Interactions – The Dangers Of Mixing Different Drugs

Methadone Drug Interactions

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Mixing any drugs will always present a risk. This is no different when it comes to Methadone. Methadone interactions can be especially dangerous, due to the number of them Methadone has. Drug interactions with Methadone can cause serious health issues and cause both long and short-term problems. So what is that makes mixing drugs so dangerous? And why would someone decide to take a drug with so many possible interactions?

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Table of Contents

What Causes Tramadol and Methadone Use?

Bottle at forefront with Methadone written on it.
Methadone is a substance that has very similar effects to Morphine. However, it is slightly longer lasting. This prescribed drug is a well-known opioid that is commonly used to treat pain and sometimes addictions such as heroin. Despite all these positive effects, it doesn’t mix well with other substances.
Mixing Methadone with other drugs can have dangerous side effects. For example, Tramadol and Methadone do not go well together at all. The two substances combined can have drastic health effects on the user, such as seizures and respiratory issues. They have even been known to cause comas, or even death on occasions when combined.
Other side effects of Tramadol and Methadone being combined are:

  • Nausea
  • Sweating
  • Mood Swings
  • Depression
  • Convulsions
  • Appetite Changes

When it comes to Methadone drug interaction, the interaction with Tramadol is one of the worst because of how deadly it can be. Mixing these drugs should be avoided without exception.

What Makes Mixing Drugs So Dangerous?

Mixing substances, in general, is dangerous. Many users do not check drug interactions before combining them, which can make the consequences all the more challenging to deal with. Due to the number of interactions any substance can have, it is a risk to mix without checking.
Mixing substances can lead to both short-term and long-term health issues. It can also in extreme cases lead to a coma or even death. This highlights the importance of knowing what one is taking, and how it interacts with other drugs.
Mixing drugs doesn’t only create physical health issues but can also affect the user psychologically. This is even more evident if depressants are mixed with stimulants. This mixture of substances causes two opposing effects on the body and mind, creating highly problematic health issues such as psychosis, mood swings and severe depression.

The Effects of Mixing Methadone With Other Drugs

Methadone drug interactions are no exception when it comes to potential danger. There are hundreds of different drugs that interact with Methadone to varying degrees, all of which can cause severe discomfort to the user.
Amongst the hundreds of substances that have severe interactions with Methadone, are Codeine, caffeine, and Ativan. These drugs and hundreds of others could have severe effects when mixed with Methadone and therefore should be avoided.
Severe reactions from mixing other substances with methadone can include anything from a nauseated feeling to severe respiratory issues such as shallow breathing or even slipping into a coma.

How To Get Help For Polydrug Abuse

If one is someone who regularly abuses a variety of substances, then tehy could be at risk of suffering from drug interactions. Polydrug abuse is very dangerous and is often a sign of addiction. It is important to get immediate medical help if noticed the signs of abuse.

The Lists of Methadone Drug Interactions

Mixture of colored tablets scattered on surface.
As with any substance, Methadone interactions come with different levels of severity. This Methadone drug interaction chart will help to clarify how severely Methadone interacts with others.
Severe Interactions

  • Methadone and antibiotics – Some antibiotics have severe interactions
  • Codeine – Nausea, seizures and sometimes death
  • Caffeine – Breathing difficulties and seizures
  • Ativan – Breathing difficulties, nausea, seizures and worse
  • And More

Serious Interactions

  • Alfentanil
  • Amphetamine
  • Lanolin
  • Labetalol
  • Kaolin
  • And More

Moderate Interactions

  • Rifabutin
  • Gantanol
  • Indinavir
  • Donepezil
  • Gabapentin and Methadone
  • Wellbutrin And Methadone

According to the US Food and Drug Administration, drugs can also interact with medical conditions, foods, and drinks. This means if one has a reaction to Methadone, and they know it isn’t related to a drug interaction then it could be for one of these other reasons.

Methadone – The Alternative To Mixing

If an individual is using Methadone, and needs to use another drug for medical reasons, there may be similar alternatives to that drug. In addition to alternative drugs, there are also natural alternatives. These options will help to avoid the worst interactions. Another option is to find an alternative to the substance that will not interact with the other drug.
For more details on suitable replacements, it is a good idea to contact a health professional, such as the doctor. They may also be able to recommend a suitable rehab for Methadone to avoid drug use altogether. This will allow the body to recover completely from drug abuse and prevent any further mixing of drugs.

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Olivier George

About Author

Olivier George, Ph.D.

Olivier George is a medical writer and head manager of the rehab center in California. He spends a lot of time in collecting and analyzing the traditional approaches for substance abuse treatment and assessing their efficiency.


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