How Long Does Lunesta Stay In The System?

Last Updated: December 18, 2019

Authored by Olivier George, Ph.D.

With a half-life of six hours, Lunesta will be out of the system for up to 24-48 hours. However, many factors might affect the duration and elimination of the drug. Dosage, age, and diet can lead to differences in excretion. Note that liver and renal problems can also influence Lunesta and its effects.

Lunesta On Drug Testing

Urinalysis can detect Lunesta. To be on the safe side, stay a whole week without Lunesta before testing or have a prescription during the testing procedure.

How Long Does Lunesta Stay In The System?

Lunesta or eszopiclone is one of the most used sleeping pills across the U.S. The drug has a half-life of around 6 hours. In general, Lunesta doesn’t accumulate in a once-daily intake. However, one might need between 1 or 2 days to get clean.

Lunesta Elimination: Factors to Consider

Like any other drug, many factors influence the effects Lunesta has on the user. Also, as Lunesta is a powerful sleeping pill, one should administer the drug with caution and only when she or he can dedicate eight hours to sleep.

Some of the factors that might affect the duration and elimination of the drug are:

  • Dosage
  • Individual differences, such as age, overall health, and history of drug abuse
  • Food intake and exercising

Note that meals rich in proteins and fiber can help one clean the body faster.

How Is Lunesta Metabolized?

How Long Does Lunesta Stay In Your System?
The body rapidly absorbs Lunesta, and then the drug undergoes hepatic oxidation and demethylation.
The drug is excreted in the urine. Note that only around 10% is excreted as parent drug, the rest are as metabolites.
In some patients with liver and renal failure, metabolism can be impaired.

Lunesta Drug Testing Information

Usually, one’ll need up to 48 hours to get clean. However, some users suggest staying away from the drug a whole week to prior testing.
Note that although it’s believed that sleeping pills like Lunesta can give a false positive for benzos, there’s no research data that backs up this belief.

How Long Does Lunesta Stay In The Blood?

Blood tests are not standard when it comes to Lunesta. However, note that the peak plasma concentrations occur within an hour after intake.

How Long Does Lunesta Stay In The Saliva and Hair?

Swab and hair tests are not used to detect Lunesta. It’s interesting to mention that Lunesta leaves some metallic taste in the mouth of the user. Also, have in mind that hair tests usually have a long window of detection (up to 90 days).

How Long Does Lunesta Stay In The Urine?

Urine tests might be used to detect Lunesta. Do not worry, though, as long as one have a prescription, it should be okay. Still, as mentioned above, stay at least 2-7 days of clean time before testing. Stay hydrated, follow a healthy diet and eat more acidic foods (grapefruit juice can be helpful).

Although Lunesta can be useful when dealing with insomnia, remember that the drug can also be habit-forming. If one is struggling with Lunesta addiction, find the best rehab near you here. Do not forget that exercising, yoga and going to bed at the same time every night can help to regulate sleep.

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Published on: June 9th, 2017

Updated on: December 18th, 2019

About Author

Olivier George, Ph.D.

Olivier George is a medical writer and head manager of the rehab center in California. He spends a lot of time in collecting and analyzing the traditional approaches for substance abuse treatment and assessing their efficiency.


Leave a comment

  • Pogey
    Lunesta never got me to sleep, but, it did make me air hungry. Anyone hear of that or had the same experience? Strange, yawned, but never got to sleep. Am up 2 hours after dose and wide awake. (Age 71)
  • Stacie
    I take Lunesta. I have been for years now. it not only puts me to sleep, I usually get 6 hours of hard rest. I do have a hard time going back to sleep after sleeping for a couple hours when I have taken my pill and if I get woken up.
    • Barbara Siry
      Hi Stacie, I’m having trouble getting enough sleep — 1 to 2 hours, and then can’t get back to sleep, sometimes at all. My GP put me on a anti depressant, but I’m not depressed, in fact, I’m fine, except this sudden onset of insomnia. I’d like to ask for Lunesta knowing that if I need to take it for years to come, it won’t lose its potency and require heavier doses. Do you take the same dose since when you started, and are there side effects?