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Lisinopril Mechanism Of Action: How Fast Does Prinivil Work?

doctor telling about lisinoril moa.

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Lisinopril is a long-acting, angiotensin-converting enzyme inhibitor that is used for the treatment of high blood pressure and to reduce the symptoms of systolic heart failure. Read along further to find out about the mechanism of action of Lisinopril, how long it takes Lisinopril to work, and whether anyone can get Lisinopril high while using it.

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Table Of Contents:

Lisinopril Mechanism Of Action

Lisinopril is primarily used for the treatment of hypertension. Lisinopril class is an ACE inhibitor. It is used either alone or in combination with other high blood pressure medicines. According to the research, when a patient suffers from high blood pressure, a substance called angiotensin II produced in the body narrows his arteries. The enzyme ACE (angiotensin-converting enzyme) produces this substance angiotensin II. ACE is also responsible for stimulating the release of the hormone aldosterone that increases the blood pressure.
Lisinopril MOA inhibits the angiotensin-converting enzyme. This, in turn, inhibits the production of angiotensin II and aldosterone to lower the blood pressure. It also works by dilating the arteries. This reduces the work the heart has to do to pump the blood throughout the body and increases the supply of oxygen to the heart. This helps in lowering the patient’s blood pressure.
In the case when Prinivil is used to treat heart failure, the Lisinopril mechanism of action constitutes increasing the supply of blood and oxygen to the heart and also dilating the blood vessels to reduce the pressure on the heart. The heart, which may be damaged and weakened due to a heart attack, is assisted in pumping blood in the body with the help of Zestril.
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How Fast Does Lisinopril Work?

Prinivil starts to work within a few hours of taking it. However, its effect is not apparent immediately. It may take two to four weeks for the effects of Prinivil to manifest themselves. Patients are advised to keep taking medicine whether they feel its impact or not. After a few weeks of treatment, its effects on lowering the blood pressure will be experienced.

Some people may experience the side effects of Lisinopril when they start taking the drug. This may cause them to stop taking it since they do not see any apparent effects of this medicine.
However, a patient should continue taking it as prescribed by the doctor to keep their blood pressure under control and reduce the risk of heart failure.

Ingredients In Lisinopril

Lisinopril ingredients constitute the active ingredient lisinopril that is responsible for inhibiting the angiotensin-converting enzyme. In addition to this active ingredient, Zestril also contains the following inactive ingredients:

  • Calcium phosphate
  • Mannitol
  • Magnesium stearate
  • Starch
  • Iron oxide (only found in 10mg and 20mg tablets)

Lisinopril High

Can one get high off Lisinopril? Lisinopril uses mainly include its use for treatment for high blood pressure and after a heart attack to help the heart in pumping blood throughout the body, as described in this study.

Just like other ACE inhibitors, Prinivil is not considered to be a potential drug of abuse. If it is combined with other blood pressure medications or alcohol, it may result in a feeling of lightheadedness or sedation, but it still does produce any psychoactive effects.

Even if the Lisinopril max dose is taken, it will not result in any kind of euphoria or a feeling of high. A high dose of Zestril can cause extremely low blood pressure that can be a serious situation that requires immediate medical help. Other than that, there is no possibility of being Lisinopril high when taking this drug.
Woman lying at home on couch.

Using Prinivil Safely

Prinivil is an effective medicine for hypertension but can cause serious side effects in some patients. Therefore, extreme caution should be observed while taking this medicine. Even on the first dose, it may cause severe side effects for some individuals who may call for discontinuation of Zestril.
However, it may take some time for the body to completely rid itself of its effects. How long lisinopril lasts in one’s system depends on its half-life. This period takes about 12 hours, which means that it will take about three days for the medicine to flush out of one’s system.
Since the Lisinopril mechanism of action constitutes lowering the patient’s blood pressure on a long-term basis, patients are advised to continue the medicine as prescribed. If any of the side effects are bothersome, the patients can consult their doctor who might prescribe some alternative to Zestril.
In rare cases, Prinivil abuse can appear in some categories of patients. They should be monitored for the warning signs if they are taking high doses of this ACE inhibitor, or using it for prolonged periods. Substance abuse may lead to severe health harm, so it must be treated as soon as possible. Consult with a healthcare professional about rehabilitation options available if substance abuse occurred to a loved one.

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  1. Edgardo Olvera Lopez, Mayur Parmar, Venkata Satish Pendela, Jamie M. Terrell, Lisinopril, 2020,
  2. Messerli FH, Kaesser UR, Lisinopril in the Treatment of Hypertension, 1989,


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