Vistaril Drug Interactions: Is Safe To Combine With Other Substances?

Last Updated: March 11, 2020

There are over 500 Vistaril drug interactions, with over 70 being major. The severity of Hydroxyzine interactions depends on the type of drug it interacts with. Some Atarax interactions can lead to fatal side effects like heart problems, while others only enhance the drowsiness.

Can one combine Vistaril and alcohol? Is it safe to Vistaril and Zoloft? What are the consequences of combining Vistaril and Xanax?

Mixing Hydroxyzine And Antihistamine

Hydroxyzine is an antihistamine which suppresses histamines in the body. It must be stressed, though, that Hydroxyzine interactions with other antihistamines can cause more problems than they solve.
The safest way to administer Vistaril is oral. Intravenous administration or Vistaril iv is unsafe and can cause problems like hemolysis (burst red blood cells).

Mix Of Tablets And Pills In The Hand

Hydroxyzine And Benadryl

Using Vistaril and Benadryl together produces a moderate drug interaction. This means that the combination is undesirable due to the side effects it provokes. Physicians should consult patients about the side effects one may experience.

Mixing Hydroxyzine And Stimulants

Hydroxyzine is considered a downer, while stimulants are uppers. In general, it is unsafe to combine these groups as the combination may yield a hip of negative consequences on a user’s body. At the same time, the outcome of interaction depends on the potency of drugs used. In this case, Hydroxyzine is a potent downer that has the ability to mitigate the effects of stimulants.

Hydroxyzine And Adderall

There aren’t many major interactions between Vistaril and Adderall. Most of the interactions are dose-based. In general, Vistaril will overshadow the euphoria induced by the Adderall due to its high potency. So, does Vistaril make one sleepy? Yes, the drug inhibits the excitation of CNS and provokes drowsiness.

Mixing Hydroxyzine And Opioids

The combination of Vistaril and opioids is quite dangerous as it can cause severe and even fatal side effects. It is more serious if an individual uses alcohol together with this combination.

Mix Of Different Drugs

Hydroxyzine And Demerol

Demerol is a common analgesic for surgical procedures. Considering the sedative effects of Atarax medicine, taking Demerol and Vistaril together can be quite dangerous. It could result in severe respiratory depression, coma, or even death.

Hydroxyzine And Oxycodone

Similar to Demerol, the combination of Vistaril and Oxycodone causes a major drug interaction that could be deadly. The Vistaril enhances the effect of Oxycodone, thus leading to hypersedation. The sedative effects would be even more dangerous if Oxycodone is used with Atarax and alcohol.

Hydroxyzine And Methadone

Vistaril and Methadone produce a serious interaction because Atarax potentiates the effect of Methadone. This can lead to dysrhythmia, which by itself is dangerous, but even more dangerous to patients dealing with cardiac issues.

Hydroxyzine And Tramadol

A combination of Vistaril and Tramadol can cause serious sedative effects that are manifested with excessive drowsiness and impaired cognitive function.

Mixing Hydroxyzine And Opioid Agonists

Opioid antagonists are useful in opioid overdoses as they prevent the opioid receptors from binding with opioids. Mixing these drugs with Vistaril usually results in serious problems.

Hydroxyzine And Suboxone

Vistaril and Suboxone cause a major drug interaction resulting in respiratory compromise and coma. It is best not to combine these substances because this can have fatal effects. Such a combination could potentially lead to unconsciousness or respiratory failure.

Mixing Hydroxyzine And Alcohol

Taking Vistaril with alcohol produces a moderate to high drug interaction in the body. Both substances serve as CNS depressants and, thus, through the concomitant use, will produce a variety of undesired effects. Combining Hydroxyzine and alcohol will result in severe drowsiness, impaired cognitive function, loss of consciousness, and respiratory depression.

Drugs And Alcohol On The Table

Mixing Hydroxyzine And Antidepressants

So, what is Atarax used for in psychiatry? Atarax is used for anxiety and relieving tension, which is similar to antidepressants. However, Atarax drug interactions with antidepressants and antibiotics can potentially cause heart problems.

Hydroxyzine And Zoloft

Vistaril and Zoloft mixing causes a moderate drug interaction. Patients may feel side effects such as problems focusing and concentrating, drowsiness, and impaired judgment. Mixing Zoloft, Vistaril, and alcohol can have fatal consequences for activities like driving.

Hydroxyzine And Lexapro

Vistaril and Lexapro interaction can lead to heart problems, such as irregular heart beating. Though this effect is rare, patients with existing cardiovascular diseases are vulnerable and require an alternative combination of drugs for their main diagnosis.

Mixing Hydroxyzine And Sedatives

Atarax and sedative drugs both produce strong sedation in people. Typically such a combo will make one very sleepy, followed by problems with concentration and judgment. One should avoid this combination before important tasks that require a clear mind.

Hydroxyzine And Ambien

Vistaril and Ambien produce a moderate drug interaction with profound drowsiness, difficulty concentrating, slow coordination, and impaired judgment. A cocktail of Ambien, Vistaril, and alcohol will only potentiate the sedative effect on CNS.

Mixing Hydroxyzine And Benzodiazepines

Benzodiazepines like Xanax are used for the treatment of conditions like panic attacks and anxiety. Hydroxyzine is also used for anxiety, but Vistaril and benzodiazepines work differently to produce the same effect. The interaction between these substances will result in increased sedation.

Hydroxyzine And Xanax

Vistaril and Xanax are both common for anxiety treatment as they both serve as CNS depressants. However, the simultaneous use of both drugs leads to profound drowsiness and reduced mental acuity. The effects can be worsened by adding alcohol to an equation. As with many other combinations, the outcome is the same – oversedation, ventilation issues, and death.

Mixing Hydroxyzine And Anticonvulsants

Anticonvulsants are a class of drugs used to counteract epileptic seizures. Combining Hydroxyzine and anticonvulsants will make one experience drowsiness and reduced cognitive activity.

Person Packing Different Meds Into A Pill Box

Hydroxyzine And Gabapentin

Gabapentin is an anticonvulsant drug used in the treatment of hot flashes, seizures, and relieving nerve pain. A combination of Vistaril and Gabapentin leads to moderate drug interaction. Feeling sleepy, difficulty concentrating and making decisions are among the common side effects.

Mixing Hydroxyzine And Antipsychotics

As with antidepressants, one must exercise caution when using Hydroxyzine and antipsychotic drugs. There is potential for side effects such as dysrhythmias, heart failure, and heart attack.

Hydroxyzine And Seroquel

As an antipsychotic drug, Seroquel is used to treat mental health problems such as schizophrenia, bipolar disorder, and manic episodes. Using Vistaril and Seroquel together can cause irregular heart beating. Other side effects may include feeling dizzy or lightheaded and diminished cognitive activity.

Avoiding Dangerous Hydroxyzine Interactions

Whether a patient chooses between Vistaril vs Atarax for their diagnosis, it is important to remember that most Hydroxyzine interactions lead to profound sedation. These effects would be much more pronounced when one mixes two drugs or more drugs, together with alcohol.

Though Vistaril is not as addictive as other drugs, drug overdose is still a concern. Hydroxyzine abuse, in combination with other substances, may provoke side effects that will affect cardiac, mental, and renal systems.

People with signs of Hydroxyzine or polydrug abuse should be admitted to the drug rehabilitation center. Special addiction treatment programs for addicts allow for a personalized approach to patient’s needs and a more coherent treatment course. Patients will start the treatment with detox, followed by a series of therapy sessions (CBT, DBT, Motivational Enhancement, etc.).

Page Sources

  1. NAMI. Vistaril Drug Summary.
  2. Patel, S., Kale, P. P., Addepalli, V., Sarkar, A., & Savai, J. (2015). Effect of a combination of duloxetine with hydroxyzine on experimental models of anxiety in mice. Indian journal of pharmacology, 47(2), 173–176.

Published on: March 11th, 2020

Updated on: March 11th, 2020


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