Hydrocodone with Homatropine: Uses, Side Effects, and Warnings

Last Updated: April 7, 2020

Authored by Olivier George, Ph.D.

Reviewed by Michael Espelin APRN

Hydrocodone bitartrate homatropine is a narcotic anti-cough medicine. The opioid in this combination acts directly on the brain to suppress the cough reflex. The homatropine component is included to prevent an overdose of the opioid. Let’s find out more about the uses, side effects, warnings, and interaction of this medicine as well as its potential for abuse and addiction.

What Is Hydrocodone Homatropine?

This is a combination medication that is used to treat a dry cough in adults and children above age 6. It includes a centrally-acting opioid as well as homatropine to prevent narcotic overdose. Hydrocodone homatropine syrup for pain may be prescribed to patients with lung cancer to treat both cough and pain. This narcotic cough suppressant is available only with a doctor’s prescription. In addition to n350 hydrocodone which is the tablet form, the drug is also available as an oral syrup or solution. The generic name of the medication is hydrocodone and homatropine, and it is available under different brand names including:

  • Hycodan
  • Hydromide
  • Hydromet
  • Hydrotropine
  • Hydropane
  • Tussigon

The opioid component of the drug has a direct effect on the cough center in the brain to suppress coughing. The homatropine component counteracts the opioid and prevents an overdose.

Proper Administration of Hydrocodone-Homatropine Syrup and Tablets

Prolonged use of opioids can lead to physical and mental dependence. If treatment is stopped suddenly, it can lead to symptoms of hydrocodone withdrawal. That’s why it is important to take hydrocodone homatropine tablets or syrup exactly as directed by a physician. The drug may become habit-forming if an individual takes more of the medicine, takes it more often, or takes it for longer than prescribed. For correct use of the medication, keep in mind:

  • The tablet should be swallowed whole without being crushed, chewed, or broken.
  • Take medicine with food – hydrocodone on an empty stomach can cause gastrointestinal upset.
  • The syrup should be measured with an appropriate measuring device (household spoons are not accurate dose measures).
  • Do not double up after a missed dose. Skip the missed dose and continue on the regular schedule.
  • Store the medication at room temperature, away from moisture, direct light, and heat. Do not freeze. Keep out of reach of children.
  • Dispose of unused medication as directed by a healthcare professional.

The medicine comes in different doses and strengths. The following formulations include 5 mg of the opioid and 1.5 mg homatropine:Hydrocodone/homatropine cough medication bottle

  • oral solution (5 mg/1.5 mg)/5 mL – Hydromet
  • hydrocodone-homatropine 5-1.5 mg/5ml syrup – Hycodan
  • hydrocodone homatropine 5 1.5mg tab – Tussigon

Possible Adverse Effects of Hycodan

Side effects of the opioid component of hydrocodone and homatropine syrup include:

  • Slowed breathing
  • Drowsiness and lethargy
  • Restlessness
  • Weakness
  • Palpitations and heart rhythm abnormalities
  • Dry mouth
  • Agitation
  • Dizziness
  • Flushing, sweating, itching
  • Constipation, nausea, vomiting
  • Mental clouding
  • Sedation
  • Seizures
  • Respiratory arrest or cardiac arrest
  • Coma

Adverse effects of the anticholinergic component, i.e., homatropine, include:

  • Vascular congestion and edema
  • Eczema
  • Increase in intraocular pressure
  • Follicular conjunctivitis

The following serious side effects require getting emergency help:

  • Difficult or labored breathing
  • Irregular breathing (fast or slow)
  • Shallow breathing
  • Blue lips, skin, or fingernails
  • Decreased urination (volume or frequency)
  • Pain or difficulty with urination (dribbling)

Hydrocodone Homatropine Syrup and Tablets: Warnings and Precautions

There is a risk of fatal adverse effects if this combination medicine of opioid and homatropine is taken with alcohol or other drugs that slow breathing or cause drowsiness. This risk is highest in children and people who use the medication without a prescription. Some of the precautions while taking hydrocodone homatropine include:

  • Do not drive or perform hazardous activities (operate heavy machinery, climb ladders) until the effect of the medicine is known.
  • Avoid taking while pregnant or breastfeeding to prevent opioid dependence in the baby.
  • The medicine is not approved for use in children under age 6.
  • Seek immediate medical attention in case of shallow breathing, extreme drowsiness, or profound weakness.

Who Should Avoid Hycodan?

Anyone who has had a previous allergic reaction to hydrocodone bit/homat syrup or other generic for hydrocodone should avoid taking medicine. In addition, the narcotic antitussive can potentially worsen the following conditions and should be used with caution in people who have:

  • Breathing trouble or asthma
  • Increased pressure in the head or head injury
  • Diabetes
  • Addison’s disease
  • Thyroid disorders
  • Substance abuse
  • Urination problems or enlarged prostate
  • Kidney or liver diseases
  • Gastrointestinal problems

Drug Interactions of Hydrocodone Homatropine

The narcotic antitussive with homatropine contains an opioid that adds to the effect of alcohol and other CNS depressants. Drug interactions with the following types of medicines can make a person profoundly drowsy and lead to other serious side effects:

  • Antihistamines for cold and allergyquestion mark made of different types of pills
  • Tranquilizers, sedatives, and sleep aids
  • Other opioid pain medicines
  • Anti-seizure medications (barbiturates)
  • Anesthetics including dental anesthetics
  • Muscle relaxants

Hycodan Cough Syrup Addiction

Some people may become addicted to a hydrocodone narcotic cough medicine in as little as two weeks, while others may not develop a dependence even after months of use. It depends on age, height and weight, metabolism, and the severity of abuse. Following an oral hydrocodone 10 mg dose, the maximum serum level of the drug is achieved 1 to 1.5 hours later. Risk factors that increase the chances of addiction to hydrocodone bitartrate and homatropine methylbromide syrup and tablets include a prior history of substance abuse in self or family or a history of crushing the pills or snorting hydrocodone acetaminophen to get a quick, powerful high.
Many people begin abusing narcotic antitussives to achieve rapid euphoria similar to the effects of heroin. In fact, abuse of prescription opioids is often a precursor to street drug abuse. Opioids are powerful substances that create artificial feelings of pleasure, reward, and satisfaction. Consistent use of these medicines leads to tolerance with progressively higher doses needed to achieve the same effects.

Detoxification and Rehabilitation from Hydromet Hydrocodone Addiction

young caring doctor developing detoxification strategy for a patientIt is possible to overcome dependence on narcotic cough suppressants by undergoing treatment for hydrocodone addiction. People who have taken the drug for a few weeks or longer are at high risk of intense and potentially dangerous withdrawal symptoms. Help is available at top-rated addiction treatment centers to withdraw safely from hydrocodone with homatropine. Doctors will recommend either short-term detoxification or an extended period of gradual withdrawal over weeks or months to come off narcotic antitussive and homatropine combination.

Find the Help

If one is addicted to hydrocodone/homatropine, call our free helpline (888)-459-5511 for more information on the right treatment option. Advisors are available to answer the questions on narcotic dependence, give more information on safe withdrawal from opioids, and guide towards enduring recovery from prescription medication abuse. Calls are always confidential and secure.

Page Sources

  1. HYCODAN (Hydrocodone Bitartrate and Homatropine Methylbromide) TABLETS AND ORAL SOLUTION, https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/005213s038lbl.pdf
  2. HYDROCODONE BITARTRATE AND HOMATROPINE METHYLBROMIDE- hydrocodone bitartrate and homatropine methylbromide solution, https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=7d45e534-338b-4c98-b85f-edd19a287e14

Published on: September 21st, 2018

Updated on: April 7th, 2020

About Author

Olivier George, Ph.D.

Olivier George is a medical writer and head manager of the rehab center in California. He spends a lot of time in collecting and analyzing the traditional approaches for substance abuse treatment and assessing their efficiency.

Medically Reviewed by

Michael Espelin APRN

8 years of nursing experience in wide variety of behavioral and addition settings that include adult inpatient and outpatient mental health services with substance use disorders, and geriatric long-term care and hospice care.  He has a particular interest in psychopharmacology, nutritional psychiatry, and alternative treatment options involving particular vitamins, dietary supplements, and administering auricular acupuncture.


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