It is crucial to keep yourself and your loved ones safe during the COVID-19 outbreak. Yet addiction may pose even a higher danger than the virus.

Learn about recovery during the pandemic:

Zolpidem Interactions With Other Medications

zolpidem interactions with other drugs

Important InformationThis information is for educational purposes only. We never invite or suggest the use, production or purchase of any these substances. Addiction Resource and it’s employees, officers, managers, agents, authors, editors, producers, and contributors shall have no direct or indirect liability, obligation, or responsibility to any person or entity for any loss, damage, or adverse consequences alleged to have happened as a consequence of material on this website. See full text of disclaimer.

Apart from using zolpidem for treating insomnia and sleep-related disorders, sometimes patients need other medicines that can lead to Ambien interactions. In specific cases, zolpidem interactions may induce severe side effects and the necessity for drug cancellation or adjusting the dosage. The following information demonstrates what drugs interact with Ambien and the possible consequences of these interactions.

Help Line Woman

Hope Without Commitment

Find the best treatment options. Call our free and confidential helpline

Most private insurances accepted

Marketing fee may apply

Learn About Zolpidem Interactions:

Ambien Minor Drug Interactions

There are very few minor interactions with zolpidem, as the drug is very potent. Mostly, minor Ambien drug interactions can occur or the effect from the drug can be reduced during interaction with caffeine, caffeine-containing medications, dietary supplements (guarana), foods, and beverages (coffee, green tea, other teas, or colas) within the hours close to bedtime. So the amount of caffeine intake should be limited during the day to promote restful sleep. Also, the Ambien strength can be decreased in the case of taking the drug during or just after the meal.

Ambien Moderate Drug Interactions


Trazodone and Ambien should be taken carefully. Using together, the additive symptoms from the central nervous system (CNS) depressant may occur, including possible respiratory depression or hypotension. Also, there is a higher chance of developing sleep-related disorders, such as sleep-driving, when taken Tradozon and zolpidem. Geriatric patients may face with impairment in thinking and motor coordination. It is recommended to decrease the dosages of both medications when used.


Taking Ambien and Benadryl together, one can experience CNS depression, such as sedating H1-blockers. There is a possibility of getting psychomotor impairment when it is needed to be in the state of sull mental alertness, including operating machinery or driving a car. The prescribed dosages of zolpidem and Benadryl need to be adjusted in case of necessity taking both drugs.


Klonopin and Ambien interaction may cause increased sedation or respiratory depression, especially in elderly or debilitated patients. Physicians may prescribe to start taking Klonopin, zolpidem, or both at lower dosages, and patients should inform about changes in their daily activities if any occur.


Before starting the treatment, it is obligatory to ask the doctor if one can take Xanax and Ambien together. The interaction between Xanax and zolpidem may lead to severe and prolonged CNS side effects. Ambulatory patients should avoid activities that require full mental concentration until they know how drugs affect them. Xanax and Ambien high is a possible effect that poses certain dangers.


Gabapentin and Ambien interaction may invoke side effects, including drowsiness, dizziness, confusion, and difficulties with attention and concentration. Patients should avoid activities that require full mental alertness. Also, there is a report about the effectiveness of treatment zolpidem dependence with Gabapentin that can be considered as a drug for detoxification.


Flexeril and Ambien interaction may cause different side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. A patient may feel difficulties in motor coordination and keeping balance. While taking zolpidem with cyclobenzaprine, a patient should avoid alcohol consumption.


The most common adverse reactions that can occur during the treatment with Zoloft and Ambien are disorientation, delusions, or hallucinations. Hallucinations can continue from 30 minutes to 7 hours and should be reported to the doctor in case of such occurs. Despite Zoloft and zolpidem facilitate different illnesses, they might be taken at different day time or not on the same day. Although these medications were both well-tolerated in healthy female volunteers during the study, they can lead to the rapid onset and stronger effect of zolpidem.


Nyquil and Ambien interaction influences the CNS and acts like depressants causing a sedating effect. In some cases, respiratory depression may occur. A patient should not perform risky activities at the beginning of the treatment and start with the lowest possible dosage.


In the case of prescribing Valium and Ambien, the patient should be aware of possible adverse reactions and inform the doctor if any occur for adjusting the dosage or changing the treatment program. The most common side effects are increased sedation or respiratory depression. Alcohol intake with Valium should be avoided.


Lexapro and Ambien interaction can invoke disorientation, hallucinations, depression, and manic reactions. Some users report having occurring anxiety in the middle of the night. At the beginning of the treatment, cautious dosage titration of Lexapro may be necessary.


Ativan and Ambien should not be taken together. Ativan and zolpidem are used to treat insomnia and help it easier to fall asleep. However, concomitant usage may lead to excessive sleepiness and sedation.


Seroquel and Ambien applying together may cause excessive drowsiness and breathing problems. Also, there is a higher chance of developing an addiction.


Ambien and ibuprofen should be watched out for possible side effects and taken cautiously only as prescripted.


The interaction of tizanidine and Ambien sometimes increase the risk of symptomatic hypotension and orthostasis, particularly during initiation of therapy or dose escalation. There is also a high chance of other side effects related to CNS disorders.


It is recommended to decrease the dosages of Ambien and Suboxone when they are prescripted together. It is better to stay away from using zolpidem with other medications at bedtime or in the middle of the night. Sedation, coma, or respiratory depression may occur during co-administration. It is advised to take half of the injectable buprenorphine dose to the patients who receive other drugs with CNS depressant effects; for the buprenorphine transdermal patch, start with the 5 mcg/hour patch. Still, consult with a doctor first.


Ambien and Lunesta are both medications that deal with insomnia by decreasing brain activity and produce a feeling of calmness. Both drugs are intended to use for a short period. Taking Lunesta with zolpidem together, one can suffer from extreme sedation, that is why it is not recommended to take them at the same time.


Prozac and Ambien interaction may induce disorientation, delusions, and impaired concentration. However, there were no severe reactions that appear during the clinical trials. The zolpidem onset of action may be shortened in the presence of fluoxetine.

Every interaction should be discussed with the doctor, and the dosages should be adjusted according to the symptoms and the patient’s reactions. Multiple drug intoxication may lead to death.

Ambien Major Drug Interactions


Patients should avoid taking Ambien and melatonin. During clinical studies, there were recorded transitory pharmacodynamic that occurred within one hour of co-dosing. The user can experience extreme sedation and impairment of memory when these two medications interact.


Percocet and Ambien interaction should be avoided. These medications should be prescribed only in urgent cases. Possible worsening in general health conditions and respiratory depression may appear when using Percoset and zolpidem together.


Ambien and tramadol interaction can damage the CNS and invoke excessive sedation and somnolence. Zolpidem overdose or polysubstance overdose is more likely to occur. Patients should immediately inform their health provider in case any unusual sleep-related behaviors and activities occur.


Hydrocodone and Ambien are dangerous interaction. The medicines can be prescribed together only when alternative treatment is inadequate. Patients should monitor their symptoms and changes in behavior at the beginning of the treatment. In the case of prolonged therapy, Stopping Ambien or hydrocodone should be executed gradually. Otherwise, severe withdrawal effects may occur.


Vicodin and Ambien interaction may cause major interaction and invoke somnolence and complex sleep-related behaviors. Opioid cough and pain medications such as Vicodin should be avoided using along with zolpidem. If there are no alternatives, and the benefits from treatment are higher than potential risks, the starting dosages should be decreased to the lowest effective one.


Using oxycodone and Ambien during the cure may result in obtaining harsh side effects such as hypotension, profound sedation, coma, respiratory depression, or even death. Before starting concurrent use, one should assess the level of tolerance to CNS depression that has developed. It is also recommended to reduce both dosages and use an initial dose of oxycodone at 1/3 to 1/2 the usual dosage.


Prescription of codeine and Ambien should be avoided unless it is the most effective approach for treatment, and risks are lower than the expected benefits. Side effects of Ambien or codeine, such as excessive sedation and complex sleep-related behaviors (sleep-driving, sleep-talking, sleep-eating) may be intensified.

Ambien And Weed Interaction

Cannabis is known among users as a natural alternative to Ambien that helps to relax muscles and provide a calming effect. However, zolpidem and cannabis, when taken together, have a moderate interaction and may result in extreme sedation. Users who suffer from sleeping problems should not take zolpidem for a long time or increase the dosage because the drug is very potent, and there is a high chance of Ambien abuse. Also, it is recommended to consult with a doctor before changing the drug and/or switching to natural relaxants such as marijuana.

Be Aware Of Zolpidem Interactions

Ambien drug interactions may change the way how the drug works and increase the possibility of adverse reactions. Different interactions can be provoked by adding sedative-hypnotics, other sleep drugs, tranquilizers, opioids, herbs, vitamins, and OTC medications to the treatment. Zolpidem and alcohol also induce severe side effects. Patients should control changes in their behavior and symptoms, and inform the doctor if any occur. Some drug interactions may cause dependence that evolves in addiction. In such cases, contacting the substance abuse centers for help is critical. These facilities provide all levels of care, as well as individualized addiction treatment.

Help Line Woman

Hope Without Commitment

Find the best treatment options. Call our free and confidential helpline

Most private insurances accepted

Marketing fee may apply

  1. Fernandes WH, Pereira Yda S, O’ Tereza S. A case of Zolpidem dependence successfully detoxified with gabapentin. Indian Journal of Psychiatry. 2013; 55(3): 290‐292. doi:10.4103/0019-5545.117152.
  2. Allard S, Sainati SM, Roth-Schechter BF. Coadministration of short-term zolpidem with sertraline in healthy women. The Journal of Clinical Pharmacology. 1999; 39(2): 184‐191. doi:10.1177/00912709922007624.
  3. Piergies AA, Sweet J, Johnson M, Roth-Schechter BF, Allard S. The effect of co-administration of zolpidem with fluoxetine: pharmacokinetics and pharmacodynamics. Int Clinical Pharmacology & Therapeutics. 1996; 34(4): 178‐183.
  4. Meeker JE, Som CW, Macapagal EC, Benson PA. Zolpidem tissue concentrations in a multiple drug related death involving Ambien. Journal of Analytical Toxicology. 1995; 19(6): 531‐534. doi:10.1093/jat/19.6.531.
Sharon Levy

About Author

Sharon Levy, MD, MPH

After successful graduation from Boston University, MA, Sharon gained a Master’s degree in Public Health. Since then, Sharon devoted herself entirely to the medical niche. Sharon Levy is also a certified addiction recovery coach.


Leave a comment