Factors That Influence the Duration of Adderall’s Presence in Your System
Adderall IR (immediate release) level reaches its peak 3 hours after ingestion, but when it comes to Adderall XR (extended release), it is approximately 7 hours. The interesting thing is that the half-life for Adderall IR is almost the same as for the XR version of the drug, lasting between 9-14 hours.
Many factors can affect how long Adderal stays in your system. Some of them are:
- Age—younger users, tend to eliminate amphetamine faster than the older ones.
- Body type—people with high levels of body fat and low muscle mass will eliminate Adderall faster than individuals with low body fat levels. Also, shorter people will remove the drug faster than taller users.
- Other substances—some substances such as MAO inhibitors may severely prolong the time needed to remove Adderall from one’s system.
- Kidney and liver function— for users who suffer from kidney or liver problems it takes more time to remove Adderall from their system.
- Levels of pH in one’s body—high urinary pH level may increase the excretion time by hours.
- Genetics—some people are genetically predisposed to eliminate amphetamine much faster because of the activity of the CYP2D6 enzyme.
- Food and water intake—the more water you drink, the higher your kidney activity will be, and Adderall will be eliminated faster. Also, taking Adderall on an empty stomach will make Adderall eliminate much quicker than taking it after a meal.
- Metabolism—if a person has a higher metabolic rate, it will take less time to eliminate Adderal from the body than for an individual who’s metabolic rate is lower.
- Dosage—if a person is taking larger doses of the drug, it will take more time to eliminate it from the body.
- The frequency of drug intake—frequent Adderall users, are more likely to store more drug in their body which means it will take more time to excrete it from the body.
- The type of Adderall—there are two types of Adderall—IR (immediate release) and XR (extended release). IR pill will eliminate faster from one’s body than the XR tablet.
How Long Does Adderall Stay in Your Blood/ Urine/ Saliva/ Hair?
According to findings from the Department of Pathology, Medical College of Virginia, you are more likely to pass a urine amphetamine test if you take a smaller dose of the drug. Also, the same study shows that almost half of the specimens were drug-free after 24 hours post ingestion. With larger doses, the drug can be detected 1 to 4 days after the last dose.
When it comes to blood tests, Adderall can be detected only after 12 to 24 hours after the last dose.
The precision of the saliva test is almost identical to a urine test, but it is not FDA approved. The drug can be detected by a saliva test from 1 to 24 hours after the last dose.
Amphetamine can be detected in hair three days after the last dose, but certain amphetamines metabolites can be found in one’s hair even after a month since the previous dose.
How is Adderall Metabolized?
It is important to note that Adderall is a prodrug, which means, it is a biologically inactive compound that is metabolized in the body in order to produce a drug. After oral administration, the drug is released in the stomach, from where it goes to the small intestines and is absorbed within seconds. As soon as the substance is absorbed, it can be detected in the blood, which indicates that the metabolic process has already begun. Once the active compounds are in the blood, it is only a matter of seconds before they reach the central nervous system, where they exude their effect on the brain.
The Duration of Adderall Effects
- The effects of Adderall IR last for 4 to 6 hours, but when it comes to Adderall XR, the effects can last up to 12 hours. For first time users, Adderall effects can last even longer.
- If a person takes this drug to get high, the effects reach their peak after only 4 hours, and then they start to fade away.
- The duration of Adderall effects also depends on a person’s metabolism, tolerance, age, nutrition, sensitivity, and general health.
How to Get Adderall Out of Your System
- Acidify your urinary pH by eating meat, grains, and dairy.
- Drink more water and eat highly acidic food.
- Take calcium-d-glucarate.
- Take an enzyme CYP2D6 inducer.