Tylenol And Alcohol: Drinking On Acetaminophen

Last Updated: April 10, 2020

Authored by Isaak Stotts, LP

Nowadays, the subject of alcohol and Tylenol (acetaminophen) use is not discussed as much as it should even though many people drink regularly, especially when socializing. Situations, where a person takes Tylenol together with the spirits drink to relieve pain or fever, are not uncommon. What happens when acetaminophen and alcohol are taken together? Do severe complications occur? What to expect when Tylenol and alcohol are mixed and what everyone should know about this, especially if someone has done it on multiple occasions? Read on to find out.

Is It Safe To Mix Tylenol And Alcohol?

Most people take this over-the-counter pill at one point or another to relieve fever or pains and aches, but the Tylenol alcohol subject requires more attention to avoid potential complications. Generally speaking, taking Tylenol with liquor is not always safe. Just like with many other medications, the human body metabolizes acetaminophen in the liver. When the recommended dosage is taken, the liver converts most of the drug into a benign substance which is then eliminated out of the body via urine. The body converts a small byproduct of metabolized Tylenol into a toxic substance, which can be quite dangerous for the liver. But, glutathione or a secondary substance minimizes the toxic effects of the drug.

Over time, especially with excessive drinking, glutathione levels can deplete, and the liver becomes more and more sensitive. Mixing alcohol and acetaminophen can be considered relatively safe in small doses, but excessive dosages can cause side effects that range from mild to severe.

Risks Of Mixing Tylenol And Alcohol

As seen above, mixing liquor, and this common pill is not always safe. How long after taking Tylenol can one drink alcohol? The answer is not quite simple and depends on a few factors, including how big is the person, Tylenol dosage, duration of use, drinking habits, among others.

Speaking of complications, common risks, and side effects that happen when alcohol acetaminophen are mixed include:

  • Rapid heartbeat
  • Upset stomach
  • Liver damage
  • Ulcers and bleeding
  • Kidney damage

The risk of the above-mentioned symptoms increases when mixing acetaminophen and alcohol in higher doses. For example, mixing Tylenol 3 and alcohol can cause severe side effects, including death.

alcohol and acetaminophen pills

AUD And Acetaminophen Overdose

Acetaminophen overdose occurs when a person intentionally or accidentally takes more than the recommended or normal amount of the medicine. In fact, acetaminophen overdose is one of the most common poisonings. Since the main goal of this post is to elucidate what happens when someone combines acetaminophen with alcohol, the overdose is a crucial point to address, especially in relation to AUD. liquor use disorder weakens the liver and increases the risk of many diseases, such as cirrhosis and fatty liver disease.

Can one drink alcohol after taking Tylenol? Most people don’t wonder about AUD cases and consequences that happen later. People who are battling AUD or have successfully beaten the addiction should bear in mind their liver is sensitive and probably damaged, so consulting a doctor about Tylenol effects could be practical. This is yet another reason why mixing Tylenol with alcohol is not a good idea.

The good news is that people with AUD who take recommended amounts of medicine are not at a higher risk of liver damage.

As long as dosages are appropriate alcohol Tylenol can be tolerated, but this is not a green light to go ahead and drink when taking pills, particularly in people with AUD. In fact, negative consequences of combining Tylenol extra strength and alcohol should be highlighted to discourage people, but should also elucidate what would happen if people with AUD whose liver is damaged take this particular medicine. At this point, not enough attention is paid in public to the habit of taking Tylenol with alcohol.

People With Increased Risk Factors

Generally speaking, everyone who mixes paracetamol and alcohol is at risk of developing side effects. But, some people, including those who mix Tylenol 3 with alcohol, are at a higher risk than others. These risk factors include:

  • AUD
  • Liver disease
  • Low levels of glutathione
  • Infection
  • Having some illness which damaged the liver
  • Taking more Tylenol than necessary

In order to weigh-in different perspectives to determine if one can drink alcohol with Tylenol, take the above-mentioned risk factors into consideration.

Safe Dose Of Alcohol To Take With Tylenol

In order to understand acetaminophen alcohol wait time, the important fact to bear in mind is that half-life of the drug is four hours after which blood levels of the drug start decreasing. In eight hours after taking the pill, blood levels of acetaminophen lower by 75%, and in 12 hours, they reduce by 88%. Although combining drugs such as Tylenol PM and alcohol is not always the wisest idea of light drinking after six hours from the last dosage is generally tolerated by the body. Make sure to consult a healthcare provider and ask him if it is safe to take Tylenol with alcohol in order to avoid potential complications. This is particularly the case for stronger instances such as hydrocodone-acetaminophen alcohol.

white pills and wine

Some people drink alcohol every day, but aches and pains can pop up, and this medicine can help eliminate them. Is there any possibility where drinking alcohol with Tylenol is okay?

Or in other words, when taking Tylenol before alcohol, is there a limit to avoid crossing in terms of drinking? Generally speaking, as long as Tylenol, after alcohol is taken as directed, drinking in moderation is okay. Here “in moderation” refers to not more than three drinks a day. Taking acetaminophen and alcohol one time can be okay, but shouldn’t turn into a habit.

What To Do If Accidentally Took Alcohol With Tylenol

Mixing Tylenol and alcohol doesn’t have to cause panic. If both substances are taken together, the answer is not to drink more alcohol and only take the recommended dose of the medicine at the frequency mentioned on the label. To avoid complications of taking Tylenol PM with alcohol, the best thing to do is to stop drinking when taking medicine to alleviate pain or fever.

Any regular drinker may be wondering how long after liquor can one take Tylenol? The answer is not easy to find as resources on this subject are scarce. Acetaminophen and alcohol interaction may not occur if a recommended dosage is taken after having a drink in people with a healthy liver. But liquor and acetaminophen can induce various problems in people with a weak liver. Wait a few hours after a drink to take this medicine.

Alternatives To Tylenol Which Are Relatively Safe With Alcohol

Some people want to know whether there are alternatives that are safe with drinking. This is especially the case for people whose alcoholic parents had a bad habit of mixing their drinks with drugs and experienced side effects in return. The good news is that there are alternatives that don’t involve taking Tylenol PM and alcohol together.

stack of different kinds of pills

Popular alternatives to acetaminophen include non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin and ibuprofen. NSAIDs work in a slightly different manner than acetaminophen and are usually fine to take with the drink. Of course, this isn’t a recommendation. Only a doctor shall determine whether benefits outweigh the risks for each individual case.

When To See A Doctor If Mixed These Two Substances

People tend to mix different substances such as caffeine and alcohol, drugs and drinks, and so much more, but don’t always think about potentially negative scenarios. For example, mixing hydrocodone acetaminophen and alcohol can cause severe complications, so a person should see or call the doctor right after. Mixing Tylenol with codeine and alcohol, especially in people with a damaged liver, can lead to further damage and serious symptoms. When to see a doctor after combining liquor with Tylenol depends on various factors, including drug dosage, amount of the drink, or whether a person has liver disease or not.

People who notice symptoms of liver disease may also want to see their doctor. These symptoms include jaundice, pain in the upper right side of the abdomen, swelling in the abdomen, loss of appetite, nausea and vomiting, tiredness, sweating, confusion, unusual bruising, or bleeding. Every person should consider the negatives as well in order to avoid having to see the doctor. If a friend or family member tends to do this without realizing that combining acetaminophen and drinks can lead to liver damage and other problems, referring them to a healthcare provider who will perform CAGE assessment could help prevent potentially lethal consequences.

Is It Really Safe?

The paracetamol-alcohol relationship is complicated, but generally speaking, moderate drinking and taking pills as directed is relatively safe. However, in people with liver damage, Tylenol and liquor death can be the most severe scenario that is bound to motivate people to avoid using medicine when drinking and vice versa. Before combining both, it’s useful to consult a healthcare provider or pharmacist.

It is also necessary to ask for help in the rehabilitation center in case there are any signs of addiction to alcohol. Alcoholism treatment is a way to start a new sober and free life.

Page Sources

  1. Natasha T. Snider, Daniel A. Portney, Helen H. Willcockson, Dhiman Maitra, Hope C. Martin, Joel K. Greenson, M. Bishr Omary. Ethanol and Acetaminophen Synergistically Induce Hepatic Aggregation and TCH346-Insensitive Nuclear Translocation of GAPDH. PLoS One. 2016; 11(8). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981434/
  2. Laurie F Prescott. Paracetamol, alcohol and the liver. Br J Clin Pharmacol. 2000 Apr; 49(4): 291–301. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2014937/
  3. Lauren L Fruchter, Iakovina Alexopoulou, Keith K Lau. Acute interstitial nephritis with acetaminophen and alcohol intoxication. Ital J Pediatr. 2011; 37: 17.

Published on: December 10th, 2019

Updated on: April 10th, 2020

About Author

Isaak Stotts, LP

Isaak Stotts is an in-house medical writer in AddictionResource. Isaak learned addiction psychology at Aspen University and got a Master's Degree in Arts in Psychology and Addiction Counseling. After graduation, he became a substance abuse counselor, providing individual, group, and family counseling for those who strive to achieve and maintain sobriety and recovery goals.


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