What Alcoholism Does To The Body: Side-Effects of Abuse

Last Updated: June 12, 2020

Authored by Nena Messina, Ph.D.

Every year, millions of people in the U.S. experience diagnosable symptoms of alcohol abuse or alcoholism. People addicted to alcohol typically undergo a range of severe changes in their day-to-day physical well-being. Some of these changes appear in a brief period, while others develop over months or years. The physical effects of alcohol can lead to severe health problems or even death. However, in people who receive treatment and establish abstinence, some of the problems triggered by chronic heavy drinking may ease in severity over time.

Physical Effects of Alcohol

Beer, wine, and hard liquor products all contain a substance called ethyl alcohol. While these products enjoy full social acceptance, ethyl alcohol itself is poisonous to the human body. Unlike food, this substance does not get broken down by the digestive system. Instead, it passes directly into the bloodstream. Three main organs bear the brunt of the harmful effects of alcohol on the body:

The liver carries responsibility for breaking alcohol down and eliminating its byproducts from the bloodstream as rapidly as possible. However, in an hour, this organ can only process the amount of pure alcohol contained in one standard drink (approximately 14 grams). Anyone who imbibes at a faster pace will be exposed to the substance’s potential harms.

Young sad man is drinking at home

In the heart, a high level of alcohol intake can disrupt the electrical signaling system that makes the organ function. In turn, this disruption can lead to a reduction in vital blood flow. Any part of the body that doesn’t receive enough blood can sustain damage as a result of insufficient nutrients or oxygen.

Inside the brain, all alcoholic beverages slow down the standard rate of activity between the nerve cells (neurons) that provide pathways for incoming and outgoing communications. If this rate falls below a sustainable point, the brain will stop sending an adequate number of signals to the lungs, heart, and other vital organs. The term used to describe this dire situation is alcohol poisoning.

In a person who establishes a pattern of heavy drinking, alcohol-related changes in the brain also set the stage for the development of alcoholism (i.e., alcohol dependence). This situation occurs when the brain grows accustomed to the chemical alterations triggered by alcohol’s presence and produces a strong, adverse reaction when levels of the substance fall too low. The long-term changes associated with alcoholism explain the condition’s accepted medical standing as a chronic brain disease.

Short-Term Effects of Alcohol on the Body

Intoxication is the primary short-term effect of heavy alcohol consumption. Some people reach an intoxicated state quickly by taking part in a practice called binge drinking, which produces drunkenness in two hours or less. Most people who go on drinking binges do not have alcoholism. Nevertheless, they can experience a range of acute harms that include:

  • Alcohol poisoning
  • Accidental injury or death
  • Sexual assault
  • Physical assault
  • Suicide

Regardless of their level of alcohol dependence, people who drink heavily in a short amount of time can also become dehydrated, develop electrolyte imbalances, or experience something called an acute kidney injury (AKI). The potential consequences of these three kidney-related problems range in severity from minor to life-threatening. Besides, repeated involvement in alcohol binging increases the odds of eventually becoming an alcoholic.

Long-Term Effects of Alcohol on the Body

The physical effects of alcohol abuse and alcoholism tend to grow progressively worse over time. In the liver, these effects can include any one of three conditions grouped under the heading of alcohol-related liver disease (ALD). The first of these conditions is known as steatosis or fatty liver. It occurs when heavy drinking triggers an unusual buildup of fat inside the organ’s cells. The second form of ALD, alcoholic hepatitis, is marked by destructive inflammation that harms or kills liver cells. The third form of ALD, cirrhosis, is characterized by the gradual replacement of healthy, functional liver tissue with useless scar tissue.

Fatty Liver

The vast majority of people with an established pattern of excessive drinking will develop a fatty liver. However, since the condition typically doesn’t produce noticeable symptoms, it often goes undetected. Mild, moderate, or severe alcoholic hepatitis affects as many as one out of three heavy drinkers. Possible signs of its presence include:

  • A tender or painful abdomen
  • Nausea and vomiting
  • Jaundice
  • High body temperature


As many as 20 percent of all heavy drinkers will develop cirrhosis. However, the disorder tends to appear only in people with a history of alcohol problems stretching back a decade or more. Many of the symptoms of cirrhosis are the same as those associated with alcoholic hepatitis. Additional possible issues include:

  • Spleen enlargement
  • Ascites (an unusual accumulation of abdominal fluid)
  • Portal hypertension (high blood pressure localized in the liver)
  • Esophageal varices (vein-related bleeding in the esophagus)

Kidney Failure

The liver-related effects of chronic alcoholism can also have a significant damaging impact on long-term kidney function. Specifically, the severe problems produced by alcoholic hepatitis and cirrhosis can trigger a form of kidney failure called hepatorenal syndrome. In many cases, this condition is first uncovered in hospitalized liver patients. In its advanced stages, it can lead to catastrophic outcomes that include large-scale organ failure, heart failure, coma, and end-stage kidney disease.

In addition to alcoholism, the long-term effects of alcohol on the brain include a decrease in the size of individual neurons and an overall reduction in the mass of the organ. In turn, these changes can lead to ongoing issues with:

  • Sleep regulation
  • The ability to regulate body temperature
  • The ability to control muscle function
  • The ability to control mood fluctuations
  • The ability to learn or use other higher mental functions

Wernicke-Korsakoff Syndrome

As a result of a chronic vitamin B1 (thiamine) deficiency, people who are dependent on alcohol can also develop a two-part condition called Wernicke-Korsakoff syndrome. The first stage of this condition, Wernicke encephalopathy, produces damage in two critical areas of the brain. The second stage, Korsakoff syndrome, usually develops in the aftermath of Wernicke encephalopathy and triggers a moderate-to-severe form of psychosis.

In the hearts of chronic heavy drinkers, the long-term effects of alcohol on the body can take the form of a condition called alcoholic cardiomyopathy. This is a form of heart failure with symptoms that can include:

  • Swelling in the abdomen
  • Breathing problems
  • Heart valve malfunctions
  • Blood clots in the heart wall
  • Unexplained weight increases
  • High urine production
  • An irregular heartbeat

Two specific types of heartbeat irregularities are associated with alcoholism: ventricular tachycardia (which affects the organ’s bottom two chambers) and atrial fibrillation (which affects the top two chambers).

Recap: What Effects Does Alcoholism Have on the Body?

Alcoholism can take a severe negative toll on systems throughout the body. In some cases, recovery from these effects is possible. For example, a person who establishes alcohol abstinence can potentially reverse the effects of fatty liver, alcoholic hepatitis, and even cirrhosis. However, once they take effect, some of the physical consequences of long-term alcoholism may last a lifetime.
Up-to-date guidelines for the diagnosis of alcohol-related problems group alcohol dependence together with non-addicted alcohol abuse under the heading of alcohol use disorder. Current federal alcoholism statistics show that more than 15 million Americans suffer from this condition. Just a fraction of those affected receives proper treatment. All told, the nationwide health care costs of heavy drinking total more than $20 billion a year. When all other economic factors are included, the annual costs rise to roughly $250 billion.

Page Sources

  1. https://medlineplus.gov/ency/article/000489.htm
  2. https://medlineplus.gov/ency/article/000771.htm

Published on: March 9th, 2018

Updated on: June 12th, 2020

About Author

Nena Messina, Ph.D.

Nena Messina is a specialist in drug-related domestic violence. She devoted her life to the study of the connection between crime, mental health, and substance abuse. Apart from her work as management at addiction center, Nena regularly takes part in the educational program as a lecturer.


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