Alcoholism and Brain Damage: Does Drinking Kills Brain Cells?

Last Updated: April 9, 2020

Authored by Nena Messina, Ph.D.

Excessive consumption of alcohol leads to harmful changes in organs and tissues throughout the human body. One of the key sites of damage is the brain. Alcoholism itself is classified as a form of brain damage or disease. In people already afflicted with alcoholism, its presence can also lead to a range of serious, severe or life-threatening changes in this vitally important organ. In addition, in women who drink heavily while pregnant, fetal brain damage from alcohol exposure can lead to the onset of fetal alcohol syndrome, a condition marked by lifelong physical changes and behavioral and learning difficulties.

What Does Alcohol Do to The Brain?

The human brain is largely composed of specialized nerve cells called neurons. Round the clock, these neurons — which number in the billions — communicate back and forth while channeling signals to and from the body. To carry out this ongoing activity, the nerve cells rely on a variety of chemicals known as neurotransmitters. Each of these chemicals triggers unique changes in the brain.Violation of brain functions
Alcohol belongs to a class of substances called central nervous system depressants. These substances get their name because they slow down the normal speed of neuron/neurotransmitter activity. When enough alcohol enters the bloodstream, this reduction in activity produces the symptoms of intoxication. In a person who drinks heavily in a short amount of time, an even greater drop in nerve cell communication can lead to the onset of the toxic reaction referred to as alcohol poisoning.
Alcohol also alters the brain’s production of specific neurotransmitters. In an area known as the pleasure center, the substance’s presence leads to the rising output of a transmitter called dopamine. Over time, the brain of a person who consumes alcohol in excessive amounts can grow accustomed to this spike in dopamine levels. It is this fundamental change that sets the stage for alcoholism (i.e., alcohol dependence).

What Part of the Brain Does Alcohol Affect?

Conceptual image of a man from side profile showing brain and brain activity
The National Institute on Alcohol Abuse and Alcoholism reports that the effects of alcohol on the brain appear in three main areas: the cerebellum, the cerebral cortex, and the limbic system. The cerebellum’s primary responsibility is the coordination of muscle movement. Damage in this area can lead to loss of body control, as well as changes in normal emotional control and memory function. The cerebral cortex serves as home to most of the higher mental abilities that distinguish human beings as a species. Damage here can interfere with the ability to do such things as:

  • Learn new information
  • Retain old information
  • Think logically
  • Solve problems
  • Plan for the future
  • Maintain impulse control

The limbic system contains the pleasure center. In addition, this network of brain structures has responsibilities that include:

  • Regulation of other emotions
  • Normal use of memory
  • Control of the body’s involuntary nervous system

Alcohol-Related Brain Damage

When exploring the impact of heavy drinking on normal brain function, it’s common to wonder if alcohol kills brain cells. On a broad level, the answer to this question is no. However, when excessive alcohol intake occurs over an extended period, it does lead to significant shrinkage in the size of the brain’s crucial neurons. In turn, this shrinkage contributes to an overall decrease in the organ’s mass or volume. Any substantial loss in brain mass can lead to the development of a range of problems, including:

  • Learning difficulties
  • Memory disruption
  • Unstable mood
  • Unstable sleep patterns
  • Unusual fluctuations in body temperature
  • A declining ability to control muscle movementBrain and glass with alcohol drink

Any assessment of how alcohol affects the brain in cases of alcoholism must also include indirect sources of damage. One example of the potential for indirect harm is a condition called hepatic encephalopathy (which roughly translates as liver-related brain damage). In people affected by this condition, the presence of alcoholic liver disease leads to the release of manganese, ammonia and other poisonous substances into the bloodstream. These substances find their way to the brain. When they do, they can severely damage the neurons and other cells. Potential consequences of hepatic encephalopathy include:

  • Symptoms of depression
  • Unusual changes in personality
  • Unusual changes in mood
  • Sleep problems
  • Declining muscle coordination

In a worst-case scenario, people affected by this disorder can fall into a coma or die.
Another indirect cause of brain damage from alcohol, Wernicke-Korsakoff syndrome, occurs in people with alcoholism who develop a persistent shortage of the B vitamin thiamine. (Such nutritional problems are common in chronic heavy drinkers.) The first stage of this condition, Wernicke encephalopathy, produces damage in two structures in the limbic system: the hypothalamus and the thalamus. Its possible consequences include:

  • Muscle coordination problems accompanied by leg tremors
  • Double vision and other changes in normal eye function
  • Confusion
  • Symptoms of alcohol withdrawal
  • A decline in mental function that can eventually result in coma

In most cases, the symptoms of Korsakoff syndrome (also known as Korsakoff psychosis) appear when the symptoms of Wernicke encephalopathy start to fade. In addition to the hallucinations common to most forms of psychosis, this syndrome can trigger:

  • Possibly severe memory loss
  • Loss of new memory production
  • A tendency to tell false stories

Effects of Alcohol on the Teenage Brain

Teenage depressed woman sitting on the staircase and drinking a beer
Current federal figures show that roughly one-third of all American 12th graders consume alcohol on a monthly basis. About 20 percent of all 10th graders also drink in a given month. These are unfortunate facts of life since research has shown that teens who drink have increased chances of altering normal brain function. This is true for two reasons. First, during adolescence, the brain has yet to complete some of its most important phases of development. Among other things, this means that the disruptions triggered by alcohol exposure can have a harmful effect on the ability to learn and process information. Also, people who start drinking before reaching adulthood increase their odds of developing clinical alcoholism or alcohol abuse during their lifetimes.

Is Alcohol Brain Damage Reversible?

Support healthy of the brain concept design.While alcohol’s effects on the brain are widespread, people affected by alcoholism-related damage can potentially recover over time. The key to recovery is successful establishment and maintenance of alcohol abstinence. After avoiding drinking for anywhere from a few months to a year or more, many people experience an increase in brain mass and an associated return in day-to-day brain function. Much of this documented improvement occurs in the cerebral cortex, the seat of higher mental function. However, positive changes may also occur in other brain areas.
People affected by hepatic encephalopathy sometimes improve when their doctors eliminate the buildup of liver toxins in their bloodstreams. However, in a significant number of cases, only a liver transplant will help restore normal brain function. Thiamine supplementation can help ease many of the symptoms of Wernicke-Korsakoff syndrome, as long as the affected person also establishes alcohol abstinence. However, even with these steps, some of the memory and thought problems triggered by Korsakoff psychosis will typically remain unchanged.

Recap: How Alcohol Affects the Brain and Behavior

alcoholismExcessive drinking clearly has a harmful effect on normal brain function. The short-term effects of alcohol on the brain include intoxication and alcohol poisoning. The long-term effects of alcohol on the brain include alcoholism and a range of damaging changes in physical, mental and behavioral well-being.
Some of the consequences of chronic heavy drinking are direct. However, the list of problems also includes hepatic encephalopathy, Wernicke-Korsakoff syndrome and other indirect outcomes. Teenagers who drink have unique brain-related risks, including heightened chances of developing alcoholism. Improvement is possible for people affected by drinking-related brain damage. However, as a rule, positive outcomes only come with successful avoidance of alcohol use.

Page Sources


Published on: March 9th, 2018

Updated on: April 9th, 2020

About Author

Nena Messina, Ph.D.

Nena Messina is a specialist in drug-related domestic violence. She devoted her life to the study of the connection between crime, mental health, and substance abuse. Apart from her work as management at addiction center, Nena regularly takes part in the educational program as a lecturer.


Leave a comment

  • Angela Bradbury
    My brother is in hospital diagnosis alcohol brain damage I know this money etc is big part to play but is there anything I can do to help